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B9JK65 (THIM_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Arad_9219
OrganismAgrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]
Taxonomic identifier311403 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383817

Sites

Binding site471Substrate; via amide nitrogen By similarity
Binding site1221ATP By similarity
Binding site1681ATP By similarity
Binding site1951Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JK65 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 0160CB3AEEE3699A

FASTA26827,572
        10         20         30         40         50         60 
MQNPTTTPGS LLTAMRANPP LVQCITNFVA MNIAANVMLA AGASPAMVHA EEEAGEFAAI 

        70         80         90        100        110        120 
SGALTINIGT LSTGWLAGMT SAAQAANKAG KPWVLDPVAH YATSFRRRSV AQLLELQPTI 

       130        140        150        160        170        180 
IRGNASEIIA LAGGTSRGQG VDSRDPVELA EEAAVQLAQK HRTIVAVTGA TDFVTDGNKA 

       190        200        210        220        230        240 
SRIEGGSPLM PQVTALGCSL TCLVGAFAAT RPDHPLDATV AALAAFAVAG ERAGRQVDGP 

       250        260 
GSFSWRFLDA LAALDEKAID SEARVISL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000629 Genomic DNA. Translation: ACM30307.1.
RefSeqYP_002541904.1. NC_011983.1.

3D structure databases

ProteinModelPortalB9JK65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311403.Arad_9219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM30307; ACM30307; Arad_9219.
GeneID7366969.
KEGGara:Arad_9219.
PATRIC20799302. VBIAgrRad129173_1778.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK841322.

Enzyme and pathway databases

BioCycARAD311403:GHU8-5583-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_AGRRK
AccessionPrimary (citable) accession number: B9JK65
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways