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B9JHZ9

- HGD_AGRRK

UniProt

B9JHZ9 - HGD_AGRRK

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei306 – 3061Proton acceptorUniRule annotation
Metal bindingi349 – 3491IronUniRule annotation
Metal bindingi355 – 3551IronUniRule annotation
Binding sitei364 – 3641homogentisateUniRule annotation
Metal bindingi385 – 3851IronUniRule annotation
Binding sitei385 – 3851homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARAD311403:GHU8-4814-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:Arad_8212
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Homogentisate 1,2-dioxygenasePRO_1000190373Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi311403.Arad_8212.

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiFQSPVAC.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JHZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQTMTQASD KEASVADKLQ YMPGFGNDFE TETLPGALPQ GQNSPQKCNY
60 70 80 90 100
GLYAEQLSGS PFTAPRGTNE RSWLYRIRPS VRHTRRFSNA SYPHWKSAPC
110 120 130 140 150
LDDHSLPLGQ LRWGPMPVPD EKLSFLDGVR TMTTAGDVLT QTGMAAHVYV
160 170 180 190 200
FNEDMVDDYA FNADGELLIV PQVGAIRVFT EMGIMDVEPL EIVLIPRGMM
210 220 230 240 250
FKVLRKGDEK VWRGYICENY GAKFTLPDRG PIGANCLANP RDFKTPVAAY
260 270 280 290 300
EDKEAPCRVH VKWCGKFYVT EIGHSPLDVV AWHGNYAPFK YDLRTFSPVG
310 320 330 340 350
AILFDHPDPS IFTVLTAPTE SAGTANVDFV IFPPRWLVAE HTFRPPWYHR
360 370 380 390 400
NIMSEFMGLI HGQYDAKEEG FVPGGISLHN MMLPHGPDAS GFEKASNSEL
410 420 430 440 450
KPVKLDHTMA FMFETRYPQQ VTKYAAELET LQDNYLECWD GLERRFDGTP

GIK
Length:453
Mass (Da):50,995
Last modified:March 24, 2009 - v1
Checksum:iF7E70699E7AFE391
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000629 Genomic DNA. Translation: ACM29541.1.
RefSeqiYP_002541138.1. NC_011983.1.

Genome annotation databases

EnsemblBacteriaiACM29541; ACM29541; Arad_8212.
GeneIDi7365865.
KEGGiara:Arad_8212.
PATRICi20797712. VBIAgrRad129173_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000629 Genomic DNA. Translation: ACM29541.1 .
RefSeqi YP_002541138.1. NC_011983.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_8212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM29541 ; ACM29541 ; Arad_8212 .
GeneIDi 7365865.
KEGGi ara:Arad_8212.
PATRICi 20797712. VBIAgrRad129173_0983.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi FQSPVAC.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci ARAD311403:GHU8-4814-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiHGD_AGRRK
AccessioniPrimary (citable) accession number: B9JHZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3