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B9JG75

- MASZ_AGRRK

UniProt

B9JG75 - MASZ_AGRRK

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Protein
Malate synthase G
Gene
glcB, Arad_0071
Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei273 – 2731Acetyl-CoA By similarity
Binding sitei310 – 3101Acetyl-CoA By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Glyoxylate By similarity
Metal bindingi429 – 4291Magnesium By similarity
Binding sitei429 – 4291Glyoxylate By similarity
Metal bindingi457 – 4571Magnesium By similarity
Binding sitei538 – 5381Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei628 – 6281Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciARAD311403:GHU8-54-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Arad_0071
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Malate synthase GUniRule annotation
PRO_1000147422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei614 – 6141Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi311403.Arad_0071.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA binding By similarity
Regioni454 – 4574Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JG75-1 [UniParc]FASTAAdd to Basket

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MSRIEKNGLQ IEPVLYDFLV KEALPGSGVD ADTFFAGFSA IVHDLAPKNR    50
ELLAKRDRMQ AAIDDWYRKN GAPVDLAAYE AFLREIGYII PEGPAFTVST 100
ANVDTEIASI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIPETD 150
GAEKGKGYNP KRGEKVIAWV RDFLDAAVPL SDASWKDVAG FAVKGGVLAI 200
ATKSGTVALT DERHFAGYLG DVAAPSHILL KNNGIHIEIV LDPSTDIGKV 250
DPAHISDVRL ESAITTIMDC EDSIAAVDAE DKAEVYRNWL GLMKGDLTEE 300
VAKGGKTFTR RLNPDVTYTA PDGASFELHC RSLMLIRNVG HLMTNPAILD 350
RDGNEVPEGI MDAMITGLIA LYDVGPKGRR KNSRAGSMYV VKPKMHGPEE 400
VAFAVEIFSR VEDVLGMPRN TIKMGIMDEE RRTTVNLKEA IRAASERVVF 450
INTGFLDRTG DEIHTSMEAG PMIRKGDMKQ AAWIAAYENW NVDIGLECGL 500
SGHAQIGKGM WAMPDLMAAM LEQKIAHPKA GANTAWVPSP TAATLHATHY 550
HKVNVANVQQ TLKSRVRAKL SDILSVPVAS RPNWTPEEIQ HEIDNNCQGI 600
LGYVVRWVDQ GVGCSKVPDI NNIGLMEDRA TLRISAQHMA NWLHHKVITE 650
AQIVETMKRM ATVVDQQNAG DPLYIAMAGN FDGSVAFQAA LELVLKGREQ 700
PNGYTEPVLH RRRIELKAKQ AV 722
Length:722
Mass (Da):78,959
Last modified:March 24, 2009 - v1
Checksum:i7734EFD58273291D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM24858.1.
RefSeqiYP_002542780.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM24858; ACM24858; Arad_0071.
GeneIDi7368768.
KEGGiara:Arad_0071.
PATRICi20800755. VBIAgrRad129173_2504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM24858.1 .
RefSeqi YP_002542780.1. NC_011985.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_0071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM24858 ; ACM24858 ; Arad_0071 .
GeneIDi 7368768.
KEGGi ara:Arad_0071.
PATRICi 20800755. VBIAgrRad129173_2504.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci ARAD311403:GHU8-54-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiMASZ_AGRRK
AccessioniPrimary (citable) accession number: B9JG75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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