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B9JFK7

- GCSP_AGRRK

UniProt

B9JFK7 - GCSP_AGRRK

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Arad_2527
Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARAD311403:GHU8-1960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Arad_2527
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000147960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi311403.Arad_2527.

Structurei

3D structure databases

ProteinModelPortaliB9JFK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JFK7-1 [UniParc]FASTAAdd to Basket

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MSTPTEFTFT DYQPYDFANR RHIGPSPSEM ADMLKVIGYS SLDKLIDATL    50
PPSIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP 100
VIQRTILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMICD LTGLDVANAS 150
LLDEATAAAE GMAMAERVAK SKAKAFFVDA DCHPQTIALI KTRAEPLGWS 200
VIVGNPFTDL DPVDVFGAIF QYPGTHGHIH DFTGLIARLH QTGAIAVVAA 250
DPLALTLLKS PGEMGADIAI GCSQRFGVPV GYGGPHAAYM AVKDAYKRSM 300
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPQGL KAIAQQVHQK AVLMAKGLEK LGYTIEQETF FDTITVEVGH 400
MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFRL 450
ADFEPGYRLP KTLLRTSEYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
SMIPLGSCTM KLNATAEMLP ISWPEFSDIH PFVPTDQALG YREMIDDLTE 550
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDICLIPTSA 600
HGTNPASAQM AGMKVVVIKV SDDGDIDMAD FRAKAEQYAA NLSCCMITYP 650
STHGVFEETV KEICDLVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKAHLAEHL PGHPETDGRP GAVSAAAFGS 750
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLKGA YDVLYKSKTG 800
RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
TESETKAELD RFCAAMLAIR EEARAIEEGR MDKTDNPLKN APHTVEDLVG 900
EWNRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CSCPPVESYA 950
EAAE 954
Length:954
Mass (Da):104,016
Last modified:March 24, 2009 - v1
Checksum:i1913D9477596C5AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM26697.1.
RefSeqiYP_002544625.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM26697; ACM26697; Arad_2527.
GeneIDi7370462.
KEGGiara:Arad_2527.
PATRICi20804714. VBIAgrRad129173_4440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM26697.1 .
RefSeqi YP_002544625.1. NC_011985.1.

3D structure databases

ProteinModelPortali B9JFK7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 311403.Arad_2527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM26697 ; ACM26697 ; Arad_2527 .
GeneIDi 7370462.
KEGGi ara:Arad_2527.
PATRICi 20804714. VBIAgrRad129173_4440.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ARAD311403:GHU8-1960-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiGCSP_AGRRK
AccessioniPrimary (citable) accession number: B9JFK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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