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B9JFK7

- GCSP_AGRRK

UniProt

B9JFK7 - GCSP_AGRRK

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciARAD311403:GHU8-1960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Arad_2527
    OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
    Taxonomic identifieri311403 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000001600: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147960Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi311403.Arad_2527.

    Structurei

    3D structure databases

    ProteinModelPortaliB9JFK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9JFK7-1 [UniParc]FASTAAdd to Basket

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    MSTPTEFTFT DYQPYDFANR RHIGPSPSEM ADMLKVIGYS SLDKLIDATL    50
    PPSIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP 100
    VIQRTILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMICD LTGLDVANAS 150
    LLDEATAAAE GMAMAERVAK SKAKAFFVDA DCHPQTIALI KTRAEPLGWS 200
    VIVGNPFTDL DPVDVFGAIF QYPGTHGHIH DFTGLIARLH QTGAIAVVAA 250
    DPLALTLLKS PGEMGADIAI GCSQRFGVPV GYGGPHAAYM AVKDAYKRSM 300
    PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YAVFHGPQGL KAIAQQVHQK AVLMAKGLEK LGYTIEQETF FDTITVEVGH 400
    MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFRL 450
    ADFEPGYRLP KTLLRTSEYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
    SMIPLGSCTM KLNATAEMLP ISWPEFSDIH PFVPTDQALG YREMIDDLTE 550
    KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDICLIPTSA 600
    HGTNPASAQM AGMKVVVIKV SDDGDIDMAD FRAKAEQYAA NLSCCMITYP 650
    STHGVFEETV KEICDLVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLAEHL PGHPETDGRP GAVSAAAFGS 750
    ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLKGA YDVLYKSKTG 800
    RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAELD RFCAAMLAIR EEARAIEEGR MDKTDNPLKN APHTVEDLVG 900
    EWNRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CSCPPVESYA 950
    EAAE 954
    Length:954
    Mass (Da):104,016
    Last modified:March 24, 2009 - v1
    Checksum:i1913D9477596C5AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000628 Genomic DNA. Translation: ACM26697.1.
    RefSeqiYP_002544625.1. NC_011985.1.

    Genome annotation databases

    EnsemblBacteriaiACM26697; ACM26697; Arad_2527.
    GeneIDi7370462.
    KEGGiara:Arad_2527.
    PATRICi20804714. VBIAgrRad129173_4440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000628 Genomic DNA. Translation: ACM26697.1 .
    RefSeqi YP_002544625.1. NC_011985.1.

    3D structure databases

    ProteinModelPortali B9JFK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 311403.Arad_2527.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM26697 ; ACM26697 ; Arad_2527 .
    GeneIDi 7370462.
    KEGGi ara:Arad_2527.
    PATRICi 20804714. VBIAgrRad129173_4440.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci ARAD311403:GHU8-1960-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K84 / ATCC BAA-868.

    Entry informationi

    Entry nameiGCSP_AGRRK
    AccessioniPrimary (citable) accession number: B9JFK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3