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B9JFK7

- GCSP_AGRRK

UniProt

B9JFK7 - GCSP_AGRRK

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARAD311403:GHU8-1960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Arad_2527
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi311403.Arad_2527.

Structurei

3D structure databases

ProteinModelPortaliB9JFK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JFK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPTEFTFT DYQPYDFANR RHIGPSPSEM ADMLKVIGYS SLDKLIDATL
60 70 80 90 100
PPSIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP
110 120 130 140 150
VIQRTILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMICD LTGLDVANAS
160 170 180 190 200
LLDEATAAAE GMAMAERVAK SKAKAFFVDA DCHPQTIALI KTRAEPLGWS
210 220 230 240 250
VIVGNPFTDL DPVDVFGAIF QYPGTHGHIH DFTGLIARLH QTGAIAVVAA
260 270 280 290 300
DPLALTLLKS PGEMGADIAI GCSQRFGVPV GYGGPHAAYM AVKDAYKRSM
310 320 330 340 350
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM
360 370 380 390 400
YAVFHGPQGL KAIAQQVHQK AVLMAKGLEK LGYTIEQETF FDTITVEVGH
410 420 430 440 450
MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFRL
460 470 480 490 500
ADFEPGYRLP KTLLRTSEYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR
510 520 530 540 550
SMIPLGSCTM KLNATAEMLP ISWPEFSDIH PFVPTDQALG YREMIDDLTE
560 570 580 590 600
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDICLIPTSA
610 620 630 640 650
HGTNPASAQM AGMKVVVIKV SDDGDIDMAD FRAKAEQYAA NLSCCMITYP
660 670 680 690 700
STHGVFEETV KEICDLVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKAHLAEHL PGHPETDGRP GAVSAAAFGS
760 770 780 790 800
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLKGA YDVLYKSKTG
810 820 830 840 850
RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP
860 870 880 890 900
TESETKAELD RFCAAMLAIR EEARAIEEGR MDKTDNPLKN APHTVEDLVG
910 920 930 940 950
EWNRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CSCPPVESYA

EAAE
Length:954
Mass (Da):104,016
Last modified:March 24, 2009 - v1
Checksum:i1913D9477596C5AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM26697.1.
RefSeqiWP_012651540.1. NC_011985.1.
YP_002544625.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM26697; ACM26697; Arad_2527.
GeneIDi7370462.
KEGGiara:Arad_2527.
PATRICi20804714. VBIAgrRad129173_4440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM26697.1 .
RefSeqi WP_012651540.1. NC_011985.1.
YP_002544625.1. NC_011985.1.

3D structure databases

ProteinModelPortali B9JFK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_2527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM26697 ; ACM26697 ; Arad_2527 .
GeneIDi 7370462.
KEGGi ara:Arad_2527.
PATRICi 20804714. VBIAgrRad129173_4440.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ARAD311403:GHU8-1960-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiGCSP_AGRRK
AccessioniPrimary (citable) accession number: B9JFK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3