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B9JFK7 (GCSP_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Arad_2527
OrganismAgrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]
Taxonomic identifier311403 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000147960

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JFK7 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 1913D9477596C5AB

FASTA954104,016
        10         20         30         40         50         60 
MSTPTEFTFT DYQPYDFANR RHIGPSPSEM ADMLKVIGYS SLDKLIDATL PPSIRQKAPL 

        70         80         90        100        110        120 
VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP VIQRTILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNYQTMICD LTGLDVANAS LLDEATAAAE GMAMAERVAK SKAKAFFVDA 

       190        200        210        220        230        240 
DCHPQTIALI KTRAEPLGWS VIVGNPFTDL DPVDVFGAIF QYPGTHGHIH DFTGLIARLH 

       250        260        270        280        290        300 
QTGAIAVVAA DPLALTLLKS PGEMGADIAI GCSQRFGVPV GYGGPHAAYM AVKDAYKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPQGL 

       370        380        390        400        410        420 
KAIAQQVHQK AVLMAKGLEK LGYTIEQETF FDTITVEVGH MQGLILRAAV AEGVNLRKVG 

       430        440        450        460        470        480 
ETKIGMSLDE RTRPATLEAV WRAFGGNFRL ADFEPGYRLP KTLLRTSEYL THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYIRR LSDRDLALDR SMIPLGSCTM KLNATAEMLP ISWPEFSDIH PFVPTDQALG 

       550        560        570        580        590        600 
YREMIDDLTE KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDICLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM AGMKVVVIKV SDDGDIDMAD FRAKAEQYAA NLSCCMITYP STHGVFEETV 

       670        680        690        700        710        720 
KEICDLVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLAEHL PGHPETDGRP GAVSAAAFGS ASILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYIAARLKGA YDVLYKSKTG RVAHECIIDT RPLVDSAGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCAAMLAIR EEARAIEEGR MDKTDNPLKN APHTVEDLVG 

       910        920        930        940        950 
EWNRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CSCPPVESYA EAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000628 Genomic DNA. Translation: ACM26697.1.
RefSeqYP_002544625.1. NC_011985.1.

3D structure databases

ProteinModelPortalB9JFK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311403.Arad_2527.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM26697; ACM26697; Arad_2527.
GeneID7370462.
KEGGara:Arad_2527.
PATRIC20804714. VBIAgrRad129173_4440.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycARAD311403:GHU8-1960-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_AGRRK
AccessionPrimary (citable) accession number: B9JFK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families