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B9JEU9

- PUR9_AGRRK

UniProt

B9JEU9 - PUR9_AGRRK

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciARAD311403:GHU8-3834-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Arad_4926
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHPRO_1000122941Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_4926.

Structurei

3D structure databases

ProteinModelPortaliB9JEU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JEU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVVSKKIPA PDKVQVKTAL LSVFDKTGIV ELARALSEKG VRLLSTGGTH
60 70 80 90 100
KAIAAAGLAV TDVSEVTAFP EIMDGRVKTL HPKVHGGLLA IRDDAEHQAA
110 120 130 140 150
MKEHGIEGID LAVINLYPFE DVRKAGGDYP TTVENIDIGG PAMIRASAKN
160 170 180 190 200
HAYVTTLTDP ADYSELLEQL SADAGQTTYD FRKRMAAKAF ARTAAYDAMI
210 220 230 240 250
ANWFAEALDI ATPRHRVIGG VLREEMRYGE NPHQKAAFYV TGENRPGVST
260 270 280 290 300
ATLLQGKQLS YNNINDTDAA YELVAEFLPE NGPACAIIKH ANPCGVATGP
310 320 330 340 350
SLVEAYKRAL ACDSVSAFGG IIALNSILDA ATAEEIVKLF TEVIIAPEVT
360 370 380 390 400
EEAKAIIARK PNLRLLSVGA LPDPRVAGLT AKTVSGGLLV QNRDNALVED
410 420 430 440 450
MELKVVTKRA PTAQELEDMK FAFRVAKHVK SNAVVYAKDG QTAGIGAGQM
460 470 480 490 500
SRVDSARIAA IKAEEAAKAM GLAEPLTRGS AVASEAFLPF ADGLLSAIAA
510 520 530
GATAVIQPGG SMRDQEVIDA ANEHNVAMVF TGIRHFRH
Length:538
Mass (Da):57,068
Last modified:March 24, 2009 - v1
Checksum:i1281D8FC5EF2F288
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM28518.1.
RefSeqiYP_002546452.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM28518; ACM28518; Arad_4926.
GeneIDi7369520.
KEGGiara:Arad_4926.
PATRICi20808570. VBIAgrRad129173_6349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM28518.1 .
RefSeqi YP_002546452.1. NC_011985.1.

3D structure databases

ProteinModelPortali B9JEU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_4926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM28518 ; ACM28518 ; Arad_4926 .
GeneIDi 7369520.
KEGGi ara:Arad_4926.
PATRICi 20808570. VBIAgrRad129173_6349.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ARAD311403:GHU8-3834-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiPUR9_AGRRK
AccessioniPrimary (citable) accession number: B9JEU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3