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B9JEU9 (PUR9_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Arad_4926
OrganismAgrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]
Taxonomic identifier311403 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000122941

Sequences

Sequence LengthMass (Da)Tools
B9JEU9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 1281D8FC5EF2F288

FASTA53857,068
        10         20         30         40         50         60 
MAVVSKKIPA PDKVQVKTAL LSVFDKTGIV ELARALSEKG VRLLSTGGTH KAIAAAGLAV 

        70         80         90        100        110        120 
TDVSEVTAFP EIMDGRVKTL HPKVHGGLLA IRDDAEHQAA MKEHGIEGID LAVINLYPFE 

       130        140        150        160        170        180 
DVRKAGGDYP TTVENIDIGG PAMIRASAKN HAYVTTLTDP ADYSELLEQL SADAGQTTYD 

       190        200        210        220        230        240 
FRKRMAAKAF ARTAAYDAMI ANWFAEALDI ATPRHRVIGG VLREEMRYGE NPHQKAAFYV 

       250        260        270        280        290        300 
TGENRPGVST ATLLQGKQLS YNNINDTDAA YELVAEFLPE NGPACAIIKH ANPCGVATGP 

       310        320        330        340        350        360 
SLVEAYKRAL ACDSVSAFGG IIALNSILDA ATAEEIVKLF TEVIIAPEVT EEAKAIIARK 

       370        380        390        400        410        420 
PNLRLLSVGA LPDPRVAGLT AKTVSGGLLV QNRDNALVED MELKVVTKRA PTAQELEDMK 

       430        440        450        460        470        480 
FAFRVAKHVK SNAVVYAKDG QTAGIGAGQM SRVDSARIAA IKAEEAAKAM GLAEPLTRGS 

       490        500        510        520        530 
AVASEAFLPF ADGLLSAIAA GATAVIQPGG SMRDQEVIDA ANEHNVAMVF TGIRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000628 Genomic DNA. Translation: ACM28518.1.
RefSeqYP_002546452.1. NC_011985.1.

3D structure databases

ProteinModelPortalB9JEU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311403.Arad_4926.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM28518; ACM28518; Arad_4926.
GeneID7369520.
KEGGara:Arad_4926.
PATRIC20808570. VBIAgrRad129173_6349.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycARAD311403:GHU8-3834-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_AGRRK
AccessionPrimary (citable) accession number: B9JEU9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways