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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotationSAAS annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Arad_1335)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei19Transition state stabilizerUniRule annotation1
Active sitei24Proton acceptorUniRule annotation1
Binding sitei75SubstrateUniRule annotation1
Binding sitei81SubstrateUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei101Proton donorUniRule annotation1
Binding sitei112SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotationSAAS annotation (EC:4.2.1.10UniRule annotationSAAS annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type II DHQaseUniRule annotation
Gene namesi
Name:aroQUniRule annotationImported
Ordered Locus Names:Arad_1928Imported
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)Imported
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000001600 Componenti: Chromosome 1

Interactioni

Subunit structurei

Homododecamer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi311403.Arad_1928

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 103Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108Z38 Bacteria
COG0757 LUCA
HOGENOMiHOG000217278
KOiK03786
OMAiCAGIVIN
OrthoDBiPOG091H03XJ

Family and domain databases

CDDicd00466 DHQase_II, 1 hit
Gene3Di3.40.50.9100, 1 hit
HAMAPiMF_00169 AroQ, 1 hit
InterProiView protein in InterPro
IPR001874 DHquinase_II
IPR018509 DHquinase_II_CS
IPR036441 DHquinase_II_sf
PANTHERiPTHR21272 PTHR21272, 1 hit
PfamiView protein in Pfam
PF01220 DHquinase_II, 1 hit
PIRSFiPIRSF001399 DHquinase_II, 1 hit
SUPFAMiSSF52304 SSF52304, 1 hit
TIGRFAMsiTIGR01088 aroQ, 1 hit
PROSITEiView protein in PROSITE
PS01029 DEHYDROQUINASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

B9JDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTIFVLNG PNLNALGKRE PGIYGGKTLK DIEADCKSVG ESLGFVIDFR
60 70 80 90 100
QSNHEGVLVD WMHEAGDTAV GVAINPGAYG HTSIALHDAI RAISVPVVEV
110 120 130 140
HISNIHAREE FRHKSMIAPA AKGMICGFGP HSYILALHAL KSITQ
Length:145
Mass (Da):15,537
Last modified:March 24, 2009 - v1
Checksum:iF06A9C3B26555BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA Translation: ACM26245.1
RefSeqiWP_007691976.1, NC_011985.1

Genome annotation databases

EnsemblBacteriaiACM26245; ACM26245; Arad_1928
KEGGiara:Arad_1928

Similar proteinsi

Entry informationi

Entry nameiB9JDP4_AGRRK
AccessioniPrimary (citable) accession number: B9JDP4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: October 25, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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