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B9JDB9 (HUTU_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Urocanate hydratase
Short name=Urocanase
EC=4.2.1.49
Alternative name(s):
Imidazolonepropionate hydrolase
Gene names
Name:hutU
Ordered Locus Names:Arad_4562
OrganismAgrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]
Taxonomic identifier311403 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium › Agrobacterium tumefaciens complex ›

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O. HAMAP-Rule MF_00577

Cofactor

Binds 1 NAD per subunit By similarity.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. HAMAP-Rule MF_00577

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the urocanase family.

Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: UniProtKB-UniPathway

histidine catabolic process to glutamate and formate

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurocanate hydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Urocanate hydratase HAMAP-Rule MF_00577
PRO_1000199892

Sites

Active site4141 By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JDB9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 6DC030E772FEFF81

FASTA56161,249
        10         20         30         40         50         60 
MTNPRHNIRE IRSPRGPELN AKSWMTEAPL RMLMNNLDPD VAENPNELVV YGGIGRAART 

        70         80         90        100        110        120 
WEDFDRIAAT LKTLTEEETL LVQSGKPVGV FRTHKDAPRV LIANSNLVPH WATWDHFNEL 

       130        140        150        160        170        180 
DKKGLAMYGQ MTAGSWIYIG TQGIVQGTYE TFVEAGRQHY NGSLKGKWIL TGGLGGMGGA 

       190        200        210        220        230        240 
QPLAAVMAGA CCLAVESDET RIDFRLRTRY VDEKATSLDE ALAMIDKWTK AGEAKSVGLL 

       250        260        270        280        290        300 
GNAAEIFPEL VKRMKAGGPR PDIVTDQTSA HDPLNGYLPL GWTVAEHKIK RESDPKAVEA 

       310        320        330        340        350        360 
AARASMKMHV EAMVAFWDAG VPTLDYGNNI RQVAKEEGFE NAFAFPGFVP AYIRPLFCRG 

       370        380        390        400        410        420 
IGPFRWAALS GDPEDIYKTD AKVKELTPGN THLHNWLDMA RERIAFQGLP ARICWVGLGD 

       430        440        450        460        470        480 
RERLGLAFNE MVKNGELKAP VVIGRDHLDS GSVASPNRET EAMKDGSDAV SDWPLLNALL 

       490        500        510        520        530        540 
NTASGATWVS LHHGGGVGMG FSQHSGMVIC ADGTDDAARR IERVLWNDPA TGVMRHADAG 

       550        560 
YDIALDCAKD KGLRLPGILG N

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000628 Genomic DNA. Translation: ACM28248.1.
RefSeqYP_002546181.1. NC_011985.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING311403.Arad_4562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM28248; ACM28248; Arad_4562.
GeneID7370305.
KEGGara:Arad_4562.
PATRIC20807990. VBIAgrRad129173_6061.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2987.
HOGENOMHOG000237606.
KOK01712.
OMAIRQMAFE.
ProtClustDBPRK05414.

Enzyme and pathway databases

BioCycARAD311403:GHU8-4058-MONOMER.
UniPathwayUPA00379; UER00550.

Family and domain databases

HAMAPMF_00577. HutU.
InterProIPR000193. Urocanase.
IPR023636. Urocanase_CS.
IPR023637. Urocanase_dom.
[Graphical view]
PANTHERPTHR32312. PTHR32312. 1 hit.
PfamPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMSSF111326. Urocanase. 1 hit.
TIGRFAMsTIGR01228. hutU. 1 hit.
PROSITEPS01233. UROCANASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHUTU_AGRRK
AccessionPrimary (citable) accession number: B9JDB9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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