B9JD13 (ARGC_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Arad_1804

Organism

Agrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]

Taxonomic identifier

311403 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000163991
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9JD13 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 976CADFFFB9F71A3	FASTA	310	33,018
	10 20 30 40 50 60 MAPKIFIDGE HGTTGLQIRT RMADRRDVEL LSIPEAERRN AAMREDMLNS ADIAILCLPD 70 80 90 100 110 120 DASKEAVKMV SANNNVRVID TSTAFRVHPD WAYGFAEMDK DQGGKITSAR FVANPGCYPT 130 140 150 160 170 180 GAVALIRPLR AAGILPDGYP VTVNAVSGYT GGGKQMIAQM ENADHPDAIT APHFLYGLPL 190 200 210 220 230 240 THKHVPEMTT HGLLDRAPIF SPSVGKFAQG MIVQVPLHLD NLAEGATMES IHAALVGHFA 250 260 270 280 290 300 GQDVVQVVSL AESRALPRIN AVELAGKDTM KLFVFGTPGT SQVNLVALLD NLGKGASGAA 310 VQNMDLMLSA

References

[1]

"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K84 / ATCC BAA-868.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000628 Genomic DNA. Translation: ACM26150.1.
RefSeq	YP_002544076.1. NC_011985.1.
3D structure databases
ProteinModelPortal	B9JD13.
ModBase	Search...
Protein-protein interaction databases
STRING	B9JD13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7371415.
GenomeReviews	Gene locus Arad_1804 in contig CP000628_GR.
KEGG	ara:Arad_1804.
PATRIC	20803534. VBIAgrRad129173_3870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PIFVPSV.
ProtClustDB	PRK11863.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR023013. AGPR_AS. IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AGRRK

Accession

Primary (citable) accession number: B9JD13

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program