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B9JCY9 (FABH_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:Arad_1772
OrganismAgrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]
Taxonomic identifier311403 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm By similarity HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3233233-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000187838

Regions

Region251 – 2555ACP-binding By similarity

Sites

Active site1131 By similarity
Active site2501 By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JCY9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 483E6B1EDBA9793B

FASTA32334,023
        10         20         30         40         50         60 
MIRSVVRGFG AALPKRVMTN RDMEQVVDTS DDWIVQRTGI RQRYIAGEGE TTASLGEQAA 

        70         80         90        100        110        120 
RAALANAGLT ADDLDMIIVA TSTPDNTFPA TAVNIQNRLG MHHGFAFDVQ AVCSGFVYAV 

       130        140        150        160        170        180 
TTADAYIRGG VAKRVLVIGA ETFSRILDWT DRTTCVLFGD GAGALILEAG EGTGANTDRG 

       190        200        210        220        230        240 
VLTASLRSDG AHKDKLYVDG GPSSTGTVGV LHMAGREVFK HAVGMITDVI EATFKAADVT 

       250        260        270        280        290        300 
ADDLDWLVPH QANRRIIDGS AKKLGIAPEK VVVTVDLHGN TSAASIPLAL AVAAGDGRIK 

       310        320 
RGDLVMLEAM GGGFTWGAVL LRW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000628 Genomic DNA. Translation: ACM26126.1.
RefSeqYP_002544052.1. NC_011985.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB9JCY9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7371391.
GenomeReviewsGene locus Arad_1772 in contig CP000628_GR.
KEGGara:Arad_1772.
PATRIC20803484. VBIAgrRad129173_3846.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMADAYIRGG.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_AGRRK
AccessionPrimary (citable) accession number: B9JCY9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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