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B9JBA3

- BETB_AGRRK

UniProt

B9JBA3 - BETB_AGRRK

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Arad_1352
Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Potassium 1 By similarity
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi244 – 2441Potassium 2; via carbonyl oxygen By similarity
Active sitei250 – 2501Proton acceptor By similarity
Binding sitei284 – 2841NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi228 – 2336NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciARAD311403:GHU8-1043-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Arad_1352
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000148553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Proteomic databases

ProMEXiB9JBA3.

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi311403.Arad_1352.

Structurei

3D structure databases

ProteinModelPortaliB9JBA3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCEHQLVA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9JBA3-1 [UniParc]FASTAAdd to Basket

« Hide

MRAQPKASHF IDGEYVEDTD GTVIESIYPA TGEVIARLHA ATPAIVEQAI    50
AAAKRAQPEW AAMSPTARGR ILKRAADIMR ERNRELSELE TLDTGKPIQE 100
TIVADPTSGA DSFEFFGGIA AAGLNGSYIP LGGDFAYTKR VPLGVCVGIG 150
AWNYPQQIAC WKGAPALVAG NAMVFKPSEN TPLGALKIAE ILIEAGLPKG 200
LYNVIQGDRE TGPLLINHPD VAKVSLTGSV PTGRKVAAAA AGSLKHVTME 250
LGGKSPLIVF DDADIDSAIG GAMLGNFYST GQVCSNGTRV FVNRKIKAEF 300
LKRLKARTEA MLIGDPMDEA TQVGPMVSWA QREKVLSYIE KGKAEGATLV 350
AGGGIPNNVS GEGYYVQPTV FADVTDDMTI AREEIFGPVM CVLDFDDEAE 400
VIARANDTEF GLSGGVFTAD LTRAHRVVDQ LEAGTLWINA YNLAPVEIPF 450
GGSKQSGFGR ENSLAALEHY SELKTVYVGM GPVQAPY 487
Length:487
Mass (Da):51,753
Last modified:March 24, 2009 - v1
Checksum:i5D1CE9618CF9FFF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM25809.1.
RefSeqiWP_012651092.1. NC_011985.1.
YP_002543735.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM25809; ACM25809; Arad_1352.
GeneIDi7368367.
KEGGiara:Arad_1352.
PATRICi20802818. VBIAgrRad129173_3514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM25809.1 .
RefSeqi WP_012651092.1. NC_011985.1.
YP_002543735.1. NC_011985.1.

3D structure databases

ProteinModelPortali B9JBA3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 311403.Arad_1352.

Proteomic databases

ProMEXi B9JBA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM25809 ; ACM25809 ; Arad_1352 .
GeneIDi 7368367.
KEGGi ara:Arad_1352.
PATRICi 20802818. VBIAgrRad129173_3514.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CEHQLVA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci ARAD311403:GHU8-1043-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiBETB_AGRRK
AccessioniPrimary (citable) accession number: B9JBA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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