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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

Arad_1335

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Arad_1335)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciARAD311403:GHU8-1021-MONOMER
UniPathwayiUPA00053; UER00084

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
DAHP synthaseUniRule annotation
Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
Gene namesi
Ordered Locus Names:Arad_1335Imported
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)Imported
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000001600 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_1335

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 337DAHP_synth_1InterPro annotationAdd BLAST294

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E99 Bacteria
COG0722 LUCA
HOGENOMiHOG000220501
KOiK01626
OMAiYDINTGL
OrthoDBiPOG091H04IK

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006218 DAHP1/KDSA
IPR006219 DHAP_synth_1
PANTHERiPTHR21225 PTHR21225, 1 hit
PfamiView protein in Pfam
PF00793 DAHP_synth_1, 1 hit
PIRSFiPIRSF001361 DAHP_synthase, 1 hit
TIGRFAMsiTIGR00034 aroFGH, 1 hit

Sequencei

Sequence statusi: Complete.

B9JAW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSTDDLRI IEITALTPPA RIIDEIPRDA AVTSAVTGAR SAVHNILHND
60 70 80 90 100
DDRLIVVIGP CSIHDPIAAR DYAARLMEQR GRFADDLEII MRVYFEKPRT
110 120 130 140 150
TVGWKGLIND PHLDGSYRIE EGLRLARQLL VDVNEIGLPA GCEFLDTITP
160 170 180 190 200
QYIADLVSWG AIGARTTESQ VHRELASGLS CPIGFKNGTN GDTRIALDAI
210 220 230 240 250
MAASQPHHFP AVTKDGLAAI ASTRGNDDGH IILRGGKQPN YDAASVQAVS
260 270 280 290 300
ELASKLGLDP QIIIDASHAN SNKNPENQPA VVSAVAAQVS AGDHRIKGMM
310 320 330 340 350
MESNIVGGRQ DLVPGKALVY GQSITDGCID WPTSVRTLEE LARAAQARRR

MSRQ
Length:354
Mass (Da):38,212
Last modified:March 24, 2009 - v1
Checksum:i615B54FAE6ACDB8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA Translation: ACM25796.1
RefSeqiWP_007694905.1, NC_011985.1

Genome annotation databases

EnsemblBacteriaiACM25796; ACM25796; Arad_1335
KEGGiara:Arad_1335

Similar proteinsi

Entry informationi

Entry nameiB9JAW3_AGRRK
AccessioniPrimary (citable) accession number: B9JAW3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: February 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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