B9JAQ3 (KHSE_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Arad_1245

Organism

Agrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]

Taxonomic identifier

311403 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000196941

Sequences

	Sequence		Length	Mass (Da)
	B9JAQ3 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 4CF2F1862090DF5B	FASTA	321	36,003
	10 20 30 40 50 60 MAVYTDITED DLKWFLTEYD VGTLLSYKGI AEGVENSNFL LHTSRDPLIL TLYEKRVEKN 70 80 90 100 110 120 DLPFFLGLMQ HLASRGLSCP LPLPRRDGEL LGHLSGRPAA LISFLEGMWL RKPEAKHCRE 130 140 150 160 170 180 VGKALAAMHV AGEGFDIKRP NALSLAGWQG LWEKSEARAD EVEPGLQDEI RGELDFLGSH 190 200 210 220 230 240 WPKDLPDGVI HADLFPDNVF FLGDELSGLI DFYFACNDQL AYDVSICLNA WCFEKDGAYN 250 260 270 280 290 300 ITKGMALLEG YQSVRPLSDA EIAALPTLSR GSALRFFLTR LYDWLTTPAG AMVTKKDPLE 310 320 YLRKLRFHRQ IASSAEYGLK A

References

[1]

"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K84 / ATCC BAA-868.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000628 Genomic DNA. Translation: ACM25736.1.
RefSeq	YP_002543662.1. NC_011985.1.
3D structure databases
ProteinModelPortal	B9JAQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	B9JAQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7371239.
GenomeReviews	Gene locus Arad_1245 in contig CP000628_GR.
KEGG	ara:Arad_1245.
PATRIC	20802664. VBIAgrRad129173_3439.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_AGRRK

Accession

Primary (citable) accession number: B9JAQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program