B9JA64 (B9JA64_AGRRK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607

Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323

Gene names

Name:	hemH HAMAP MF_00323 EMBL ACM27679.1
Ordered Locus Names:	Arad_3821

Organism

Agrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]

Taxonomic identifier

311403 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Ontologies

Keywords
Biological process	Heme biosynthesis HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015 Porphyrin biosynthesis HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015
Cellular component	Cytoplasm HAMAP MF_00323
Ligand	Iron HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015 Metal-binding HAMAP MF_00323 SAAS SAAS001015
Molecular function	Lyase HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	211	1	Iron By similarity HAMAP MF_00323
	Metal binding	292	1	Iron By similarity HAMAP MF_00323

Sequences

	Sequence		Length	Mass (Da)
	B9JA64 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 0E2D1DB7129C18A0	FASTA	341	38,769
	10 20 30 40 50 60 MTAEAATGQL QQKSGRIGVL LVNLGTPDGT DYTSMRRYLR EFLSDKRVIE LPRWKWYPVL 70 80 90 100 110 120 FGIVLNTRPQ KVGKAYETIW NKDKNESYLR TYTRNQSNLM AERLADLPAV VVDWAMRYGT 130 140 150 160 170 180 PSIGDRIQAL KDQGCDRIVL FPLYPQYAAA TTATVNDKAF EKLVKMRWQP ALRTVPDYHS 190 200 210 220 230 240 DPTYIDALAK SITRHLATLD WLPEKILASF HGIPLSYSEK GDPYYAQCIE TGRLLREKLG 250 260 270 280 290 300 LADDQFIVTF QSRFGPEEWL QPYTDKTVES LARDGTKRIA VLNPGFVSDC LETLEEIAEQ 310 320 330 340 AAESFHHNGG EKFTHIPCLN DGEDGMRVLE AVVRRELSGW A

References

[1]

"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000628 Genomic DNA. Translation: ACM27679.1.
RefSeq	YP_002545610.1. NC_011985.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9JA64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7369319.
GenomeReviews	Gene locus Arad_3821 in contig CP000628_GR.
KEGG	ara:Arad_3821.
PATRIC	20806796. VBIAgrRad129173_5476.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TIEEIGM.
ProtClustDB	PRK00035.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9JA64_AGRRK

Accession

Primary (citable) accession number: B9JA64

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)