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B9J7E8

- FTHS_AGRRK

UniProt

B9J7E8 - FTHS_AGRRK

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARAD311403:GHU8-2529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Arad_3259
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_1000185241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_3259.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9J7E8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVKSDIEI ARAAKKLPII EIGAKLGIPA EDLAPYGHDK AKIGAQFIAA
60 70 80 90 100
LKDKPDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCVREAS
110 120 130 140 150
LGPCFGVKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLAALIDNH
160 170 180 190 200
IYWGNEENID VRRITWRRAM DMNDRALRDI VASLGGVANG YPREGGFDIT
210 220 230 240 250
VASEVMAILC LASDLKDLEK RLGDIIIGYR RDRTPVYARD LKADGAMAVL
260 270 280 290 300
LKDAMQPNLV QTLENNPALV HGGPFANIAH GCNSVIATRT ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK AGLAPDAAVI VATVRALKMN GGVKKDDLGQ
360 370 380 390 400
ENVEALVKGC ANLGRHLANV RKFGVPVVVA INHFVSDTNA EIEAVKNYVA
410 420 430 440 450
RLGAEAILCR HWAEGSAGIE ELAYKVVELA ESGQAKFQPL YPDNLPLLEK
460 470 480 490 500
IEIVASKIYH AGEVTADKAV RDQLRSWEDQ GYGYLPVCMA KTQYSFSTDP
510 520 530 540 550
NVRGAPEGHI VQVREVRLSA GAGFVVVITG EIMTMPGLPK APAAERIFLN

DQGYIEGLF
Length:559
Mass (Da):59,808
Last modified:March 24, 2009 - v1
Checksum:i55BFD8A7FFF40F96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1.
RefSeqiYP_002545185.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM27255; ACM27255; Arad_3259.
GeneIDi7370123.
KEGGiara:Arad_3259.
PATRICi20805917. VBIAgrRad129173_5039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1 .
RefSeqi YP_002545185.1. NC_011985.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_3259.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM27255 ; ACM27255 ; Arad_3259 .
GeneIDi 7370123.
KEGGi ara:Arad_3259.
PATRICi 20805917. VBIAgrRad129173_5039.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ARAD311403:GHU8-2529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiFTHS_AGRRK
AccessioniPrimary (citable) accession number: B9J7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3