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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARAD311403:GHU8-2529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Arad_3259
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_1000185241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_3259.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9J7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVKSDIEI ARAAKKLPII EIGAKLGIPA EDLAPYGHDK AKIGAQFIAA
60 70 80 90 100
LKDKPDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCVREAS
110 120 130 140 150
LGPCFGVKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLAALIDNH
160 170 180 190 200
IYWGNEENID VRRITWRRAM DMNDRALRDI VASLGGVANG YPREGGFDIT
210 220 230 240 250
VASEVMAILC LASDLKDLEK RLGDIIIGYR RDRTPVYARD LKADGAMAVL
260 270 280 290 300
LKDAMQPNLV QTLENNPALV HGGPFANIAH GCNSVIATRT ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK AGLAPDAAVI VATVRALKMN GGVKKDDLGQ
360 370 380 390 400
ENVEALVKGC ANLGRHLANV RKFGVPVVVA INHFVSDTNA EIEAVKNYVA
410 420 430 440 450
RLGAEAILCR HWAEGSAGIE ELAYKVVELA ESGQAKFQPL YPDNLPLLEK
460 470 480 490 500
IEIVASKIYH AGEVTADKAV RDQLRSWEDQ GYGYLPVCMA KTQYSFSTDP
510 520 530 540 550
NVRGAPEGHI VQVREVRLSA GAGFVVVITG EIMTMPGLPK APAAERIFLN

DQGYIEGLF
Length:559
Mass (Da):59,808
Last modified:March 24, 2009 - v1
Checksum:i55BFD8A7FFF40F96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1.
RefSeqiWP_012651982.1. NC_011985.1.
YP_002545185.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM27255; ACM27255; Arad_3259.
KEGGiara:Arad_3259.
PATRICi20805917. VBIAgrRad129173_5039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1.
RefSeqiWP_012651982.1. NC_011985.1.
YP_002545185.1. NC_011985.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi311403.Arad_3259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM27255; ACM27255; Arad_3259.
KEGGiara:Arad_3259.
PATRICi20805917. VBIAgrRad129173_5039.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciARAD311403:GHU8-2529-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiFTHS_AGRRK
AccessioniPrimary (citable) accession number: B9J7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 27, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.