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B9J7E8

- FTHS_AGRRK

UniProt

B9J7E8 - FTHS_AGRRK

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARAD311403:GHU8-2529-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Arad_3259
    OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
    Taxonomic identifieri311403 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
    ProteomesiUP000001600: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_1000185241Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi311403.Arad_3259.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9J7E8-1 [UniParc]FASTAAdd to Basket

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    MATVKSDIEI ARAAKKLPII EIGAKLGIPA EDLAPYGHDK AKIGAQFIAA    50
    LKDKPDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCVREAS 100
    LGPCFGVKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLAALIDNH 150
    IYWGNEENID VRRITWRRAM DMNDRALRDI VASLGGVANG YPREGGFDIT 200
    VASEVMAILC LASDLKDLEK RLGDIIIGYR RDRTPVYARD LKADGAMAVL 250
    LKDAMQPNLV QTLENNPALV HGGPFANIAH GCNSVIATRT ALKLADYVVT 300
    EAGFGADLGA EKFFDIKCRK AGLAPDAAVI VATVRALKMN GGVKKDDLGQ 350
    ENVEALVKGC ANLGRHLANV RKFGVPVVVA INHFVSDTNA EIEAVKNYVA 400
    RLGAEAILCR HWAEGSAGIE ELAYKVVELA ESGQAKFQPL YPDNLPLLEK 450
    IEIVASKIYH AGEVTADKAV RDQLRSWEDQ GYGYLPVCMA KTQYSFSTDP 500
    NVRGAPEGHI VQVREVRLSA GAGFVVVITG EIMTMPGLPK APAAERIFLN 550
    DQGYIEGLF 559
    Length:559
    Mass (Da):59,808
    Last modified:March 24, 2009 - v1
    Checksum:i55BFD8A7FFF40F96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000628 Genomic DNA. Translation: ACM27255.1.
    RefSeqiWP_012651982.1. NC_011985.1.
    YP_002545185.1. NC_011985.1.

    Genome annotation databases

    EnsemblBacteriaiACM27255; ACM27255; Arad_3259.
    GeneIDi7370123.
    KEGGiara:Arad_3259.
    PATRICi20805917. VBIAgrRad129173_5039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000628 Genomic DNA. Translation: ACM27255.1 .
    RefSeqi WP_012651982.1. NC_011985.1.
    YP_002545185.1. NC_011985.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 311403.Arad_3259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM27255 ; ACM27255 ; Arad_3259 .
    GeneIDi 7370123.
    KEGGi ara:Arad_3259.
    PATRICi 20805917. VBIAgrRad129173_5039.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci ARAD311403:GHU8-2529-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K84 / ATCC BAA-868.

    Entry informationi

    Entry nameiFTHS_AGRRK
    AccessioniPrimary (citable) accession number: B9J7E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3