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B9J7E8

- FTHS_AGRRK

UniProt

B9J7E8 - FTHS_AGRRK

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Arad_3259
Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARAD311403:GHU8-2529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Arad_3259
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000185241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_3259.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9J7E8-1 [UniParc]FASTAAdd to Basket

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MATVKSDIEI ARAAKKLPII EIGAKLGIPA EDLAPYGHDK AKIGAQFIAA    50
LKDKPDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCVREAS 100
LGPCFGVKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLAALIDNH 150
IYWGNEENID VRRITWRRAM DMNDRALRDI VASLGGVANG YPREGGFDIT 200
VASEVMAILC LASDLKDLEK RLGDIIIGYR RDRTPVYARD LKADGAMAVL 250
LKDAMQPNLV QTLENNPALV HGGPFANIAH GCNSVIATRT ALKLADYVVT 300
EAGFGADLGA EKFFDIKCRK AGLAPDAAVI VATVRALKMN GGVKKDDLGQ 350
ENVEALVKGC ANLGRHLANV RKFGVPVVVA INHFVSDTNA EIEAVKNYVA 400
RLGAEAILCR HWAEGSAGIE ELAYKVVELA ESGQAKFQPL YPDNLPLLEK 450
IEIVASKIYH AGEVTADKAV RDQLRSWEDQ GYGYLPVCMA KTQYSFSTDP 500
NVRGAPEGHI VQVREVRLSA GAGFVVVITG EIMTMPGLPK APAAERIFLN 550
DQGYIEGLF 559
Length:559
Mass (Da):59,808
Last modified:March 24, 2009 - v1
Checksum:i55BFD8A7FFF40F96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1.
RefSeqiWP_012651982.1. NC_011985.1.
YP_002545185.1. NC_011985.1.

Genome annotation databases

EnsemblBacteriaiACM27255; ACM27255; Arad_3259.
GeneIDi7370123.
KEGGiara:Arad_3259.
PATRICi20805917. VBIAgrRad129173_5039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000628 Genomic DNA. Translation: ACM27255.1 .
RefSeqi WP_012651982.1. NC_011985.1.
YP_002545185.1. NC_011985.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_3259.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM27255 ; ACM27255 ; Arad_3259 .
GeneIDi 7370123.
KEGGi ara:Arad_3259.
PATRICi 20805917. VBIAgrRad129173_5039.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ARAD311403:GHU8-2529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiFTHS_AGRRK
AccessioniPrimary (citable) accession number: B9J7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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