B9J6V8 (ADE_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

Arad_0352

Organism

Agrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]

Taxonomic identifier

311403 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Adenine deaminase HAMAP MF_01962		PRO_1000146562
Sites
	Active site	192	1	Proton donor By similarity
	Metal binding	11	1	Zinc; catalytic By similarity
	Metal binding	13	1	Zinc; catalytic By similarity
	Metal binding	189	1	Zinc; catalytic By similarity
	Metal binding	270	1	Zinc; catalytic By similarity
	Binding site	271	1	Substrate By similarity
	Site	213	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9J6V8 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 770909040FF1C1B4	FASTA	322	35,098
	10 20 30 40 50 60 MTSHLKKVEL HCHLEGAAPP ALTLAQARKY NVDTNAFMRD GVYLWKDFAE FLVCYDKVSE 70 80 90 100 110 120 VYRTEEDYAL LTETYLEELA GIGTIYSELI VSPDHGDRIG LGADAYMEGV SAGIRAAKEK 130 140 150 160 170 180 SGIEARLIVT GERHFGPERV VKAAEYAAKS DNPLISGFNM AGEERMGRVA DYARAFDIAR 190 200 210 220 230 240 EAGLGITIHA GEVCGAFSVA DAVELVRPAR IGHGVRAIED ADLVKRLADL GTVLEVCPGS 250 260 270 280 290 300 NIALNVFPDF PSHPLRKLRD AGVRVTISSD DPPFFHTSLK REYELASTAF GFSDDEINAM 310 320 TRTAIEAAFL DEATRAALLA RL

References

[1]

"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K84 / ATCC BAA-868.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000628 Genomic DNA. Translation: ACM25064.1.
RefSeq	YP_002542989.1. NC_011985.1.
3D structure databases
ProteinModelPortal	B9J6V8.
ModBase	Search...
Protein-protein interaction databases
STRING	B9J6V8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7369715.
GenomeReviews	Gene locus Arad_0352 in contig CP000628_GR.
KEGG	ara:Arad_0352.
PATRIC	20801231. VBIAgrRad129173_2728.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IVLECCP.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_AGRRK

Accession

Primary (citable) accession number: B9J6V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program