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B9J2H2 (B9J2H2_BACCQ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase 2 HAMAP MF_00488
Short name=L-LDH 2 HAMAP MF_00488
EC=1.1.1.27 HAMAP MF_00488
Gene names
Name:ldhP EMBL ACM15115.1
Synonyms:ldh2 HAMAP MF_00488
Ordered Locus Names:BCQ_4689
OrganismBacillus cereus (strain Q1) [Complete proteome] [HAMAP]
Taxonomic identifier361100 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488

Subunit structure

Homotetramer By similarity. HAMAP MF_00488

Subcellular location

Cytoplasm By similarity HAMAP MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family. HAMAP MF_00488

Ontologies

Keywords
   Biological processGlycolysis HAMAP MF_00488
   Cellular componentCytoplasm HAMAP MF_00488
   LigandNAD HAMAP MF_00488
   Molecular functionOxidoreductase HAMAP MF_00488
   PTMPhosphoprotein HAMAP MF_00488
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding14 – 4229NAD By similarity HAMAP MF_00488

Sites

Active site1781Proton acceptor By similarity HAMAP MF_00488
Binding site911Substrate By similarity HAMAP MF_00488
Binding site1231NAD or substrate By similarity HAMAP MF_00488
Binding site1541Substrate By similarity HAMAP MF_00488
Binding site2321Substrate By similarity HAMAP MF_00488

Amino acid modifications

Modified residue2231Phosphotyrosine By similarity HAMAP MF_00488

Sequences

Sequence LengthMass (Da)Tools
B9J2H2 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 82075E6DCC076A76

FASTA31434,606
        10         20         30         40         50         60 
MKKGINRVVL VGTGAVGCSY AYSMINQGVA EEFVLVDVNE AKAEGEAMDL SHAVPFSPSP 

        70         80         90        100        110        120 
TKVWSGSYAD CKDADLVVIT AGLPQKPGET RLDLVEKNTK IFKQIVRGIM DSGFDGIFLI 

       130        140        150        160        170        180 
ATNPVDILTY VTWKESGLPK ERVIGSGTTL DSARFRYMLG DYLDVDPRNV HAYIVGEHGD 

       190        200        210        220        230        240 
TELPVWSHAT IGVQKLETIL ANNEQYKQED LDKIFENVRD AAYHIIERKG ATYYGIGMSL 

       250        260        270        280        290        300 
LRVTKAILNN ENSVLTVSAY LEGQYGEKDA YVGVPAVINR EGVREIVELE LNEDEKAKFA 

       310 
HSVKVLKETM APVL

« Hide

References

[1]"Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications."
Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q.
J. Bacteriol. 191:1120-1121(2009) [PubMed: 19060151] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000227 Genomic DNA. Translation: ACM15115.1.
RefSeqYP_002532404.1. NC_011969.1.

3D structure databases

ProteinModelPortalB9J2H2.
SMRB9J2H2. Positions 4-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGB9J2H2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000100554; EBBACP00000097339; EBBACG00000100547.
GeneID7373700.
GenomeReviewsGene locus BCQ_4689 in contig CP000227_GR.
KEGGbcq:BCQ_4689.
PATRIC18917173. VBIBacCer120424_4751.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000001153.
OMAHECKQIS.
ProtClustDBPRK00066.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00016.
PANTHERPTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB9J2H2_BACCQ
AccessionPrimary (citable) accession number: B9J2H2
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info