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Protein

Alanine racemase

Gene

alr

Organism
Bacillus cereus (strain Q1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (dal)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BCQ_0268Imported
OrganismiBacillus cereus (strain Q1)Imported
Taxonomic identifieri361100 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000441 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB9J0N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 374Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B9J0N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAPFYRDT WVEVDLDAIY NNVTHIKEFI PSDVEIFAVV KGNAYGHDYV
60 70 80 90 100
PVAKTALEAG ATRLAVAFLD EALVLRRAGI TAPILVLGPS PPRDINVAAE
110 120 130 140 150
NDVALTVFQK EWVDEAIKLW DGSSTMKYHI NFDSGMGRIG IRERKELKGF
160 170 180 190 200
LKSLEGAPFL ELEGVYTHFA TADEVETSYF DKQYNTFLEQ LSWLKEFGVD
210 220 230 240 250
PKFVHTANSA ATLRFQGITF NAVRIGIAMY GLSPSVEIRP FLPFKLEPAL
260 270 280 290 300
SLHTKVAHIK QVIKGDGISY NVTYRTKTEE WIATVAIGYA DGWLRRLQGF
310 320 330 340 350
EVLVNGKRVP IVGRVTMDQF MIHLPCKVPL GTKVTLIGRQ GDEYISATEV
360 370 380
AEYSGTINYE IITTISFRVP RIFIRNGKVV EVINYLNDI
Length:389
Mass (Da):43,649
Last modified:March 24, 2009 - v1
Checksum:iE26652ECAA0961A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000227 Genomic DNA. Translation: ACM10771.1.
RefSeqiWP_000390601.1. NC_011969.1.

Genome annotation databases

EnsemblBacteriaiACM10771; ACM10771; BCQ_0268.
KEGGibcq:BCQ_0268.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB9J0N7_BACCQ
AccessioniPrimary (citable) accession number: B9J0N7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported