Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Bacillus cereus (strain Q1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBCER361100:GJ7M-4385-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:citCImported
Ordered Locus Names:BCQ_4397Imported
OrganismiBacillus cereus (strain Q1)Imported
Taxonomic identifieri361100 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000441 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi361100.BCQ_4397.

Structurei

3D structure databases

ProteinModelPortaliB9J093.
SMRiB9J093. Positions 6-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9J093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVITLTTGE KITVTNGVMN VPNNPIIPFI EGDGIGPDIW AAASRVLEAA
60 70 80 90 100
VEKAYDGEKK IVWKEVLAGE KAFNQTGEWL PEETLNLIRE YLIAIKGPLT
110 120 130 140 150
TPVGGGIRSL NVALRQELDL YVCLRPVRYF EGVPSPVKRP EDTDMVIFRE
160 170 180 190 200
NTEDIYAGIE YAQGSPEAEK VLAFLKEAMG VNKIRFPETS GIGIKPISEE
210 220 230 240 250
GTKRLVRAAI QYAINEKRSS VTLVHKGNIM KFTEGAFKNW GYEVAEQEFG
260 270 280 290 300
DKVFTWAEYD RIVEKDGKDA ANKAMADAEV AGKIIVKDSI ADIFLQQILT
310 320 330 340 350
RPREFDVVAT MNLNGDYISD ALAAQVGGIG IAPGANINYV TGHAIFEATH
360 370 380 390 400
GTAPKYAGLD KVNPSSVLLS GVLLLEHLGW NEAAKLVTAS VEKTIASKVV
410 420 430
TYDFARLMEG ATEVKCSEFA NELIKNMDVA IIKNA
Length:435
Mass (Da):47,456
Last modified:March 24, 2009 - v1
Checksum:iE94BE98AA86D696F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000227 Genomic DNA. Translation: ACM14823.1.
RefSeqiYP_002532112.1. NC_011969.1.

Genome annotation databases

EnsemblBacteriaiACM14823; ACM14823; BCQ_4397.
KEGGibcq:BCQ_4397.
PATRICi18916571. VBIBacCer120424_4451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000227 Genomic DNA. Translation: ACM14823.1.
RefSeqiYP_002532112.1. NC_011969.1.

3D structure databases

ProteinModelPortaliB9J093.
SMRiB9J093. Positions 6-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi361100.BCQ_4397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM14823; ACM14823; BCQ_4397.
KEGGibcq:BCQ_4397.
PATRICi18916571. VBIBacCer120424_4451.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciBCER361100:GJ7M-4385-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications."
    Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q.
    J. Bacteriol. 191:1120-1121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Q1Imported.

Entry informationi

Entry nameiB9J093_BACCQ
AccessioniPrimary (citable) accession number: B9J093
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.