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B9IY25 (NAMA_BACCQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADPH dehydrogenase

EC=1.6.99.1
Gene names
Name:namA
Ordered Locus Names:BCQ_2023
OrganismBacillus cereus (strain Q1) [Complete proteome] [HAMAP]
Taxonomic identifier361100 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP-Rule MF_01614

Catalytic activity

NADPH + acceptor = NADP+ + reduced acceptor. HAMAP-Rule MF_01614

Cofactor

FMN By similarity. HAMAP-Rule MF_01614

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01614

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345NADPH dehydrogenase HAMAP-Rule MF_01614
PRO_1000185863

Regions

Nucleotide binding23 – 275FMN By similarity

Sites

Binding site281Substrate By similarity
Binding site1641Substrate By similarity
Binding site1671Substrate By similarity
Binding site2151FMN By similarity
Binding site3081FMN By similarity

Sequences

Sequence LengthMass (Da)Tools
B9IY25 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: AF0F3C5C34479A44

FASTA34538,605
        10         20         30         40         50         60 
MNYKLFSPYT IKDVTLKNRI VMSPMCMYSS KNEDGQITNF HLIHYGTRAA GQVGLVMIEA 

        70         80         90        100        110        120 
TAVLPEGRIS NKDLGIWDDS LIEGLHKATT FIHDNGAKAA IQLAHAGRKA ELETDALAPS 

       130        140        150        160        170        180 
AIPFNETMKM PIEMSKHQIK DTVLAFQQAA VRSKQAGFDV IEIHGAHGYL INEFLSPLTN 

       190        200        210        220        230        240 
KRTDEYGGSP ENRYRFLREI IESINEVWNG PLFVRISAND YHPDGLTVQD YVQYTKWMKE 

       250        260        270        280        290        300 
QGVDLIDCSS GAVVPARIDV YPGYQVQYAK HIKEHANIAT GAVGLITTGA QAEQILNNNE 

       310        320        330        340 
ADLIFIGREL LRNPYFPRIA ANELGFELEE PYQYERAPGK ISTNK 

« Hide

References

[1]"Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications."
Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q.
J. Bacteriol. 191:1120-1121(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Q1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000227 Genomic DNA. Translation: ACM12451.1.
RefSeqYP_002529740.1. NC_011969.1.

3D structure databases

ProteinModelPortalB9IY25.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING361100.BCQ_2023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM12451; ACM12451; BCQ_2023.
GeneID7377260.
KEGGbcq:BCQ_2023.
PATRIC18911617. VBIBacCer120424_1978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1902.
HOGENOMHOG000116232.
KOK00356.
OMAPWLGKHG.
OrthoDBEOG60PHD0.

Enzyme and pathway databases

BioCycBCER361100:GJ7M-2010-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01614. NamA.
InterProIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAMA_BACCQ
AccessionPrimary (citable) accession number: B9IY25
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families