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B9IY25

- NAMA_BACCQ

UniProt

B9IY25 - NAMA_BACCQ

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Protein

NADPH dehydrogenase

Gene

namA

Organism
Bacillus cereus (strain Q1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

Cofactori

FMN.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Binding sitei215 – 2151FMNUniRule annotation
Binding sitei308 – 3081FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 275FMNUniRule annotation

GO - Molecular functioni

  1. FMN binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
  4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
  5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciBCER361100:GJ7M-2010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
Gene namesi
Name:namAUniRule annotation
Ordered Locus Names:BCQ_2023
OrganismiBacillus cereus (strain Q1)
Taxonomic identifieri361100 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000441: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345NADPH dehydrogenasePRO_1000185863Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi361100.BCQ_2023.

Structurei

3D structure databases

ProteinModelPortaliB9IY25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1902.
HOGENOMiHOG000116232.
KOiK00356.
OMAiPWLGKHG.
OrthoDBiEOG60PHD0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01614. NamA.
InterProiIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9IY25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYKLFSPYT IKDVTLKNRI VMSPMCMYSS KNEDGQITNF HLIHYGTRAA
60 70 80 90 100
GQVGLVMIEA TAVLPEGRIS NKDLGIWDDS LIEGLHKATT FIHDNGAKAA
110 120 130 140 150
IQLAHAGRKA ELETDALAPS AIPFNETMKM PIEMSKHQIK DTVLAFQQAA
160 170 180 190 200
VRSKQAGFDV IEIHGAHGYL INEFLSPLTN KRTDEYGGSP ENRYRFLREI
210 220 230 240 250
IESINEVWNG PLFVRISAND YHPDGLTVQD YVQYTKWMKE QGVDLIDCSS
260 270 280 290 300
GAVVPARIDV YPGYQVQYAK HIKEHANIAT GAVGLITTGA QAEQILNNNE
310 320 330 340
ADLIFIGREL LRNPYFPRIA ANELGFELEE PYQYERAPGK ISTNK
Length:345
Mass (Da):38,605
Last modified:March 24, 2009 - v1
Checksum:iAF0F3C5C34479A44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000227 Genomic DNA. Translation: ACM12451.1.
RefSeqiYP_002529740.1. NC_011969.1.

Genome annotation databases

EnsemblBacteriaiACM12451; ACM12451; BCQ_2023.
GeneIDi7377260.
KEGGibcq:BCQ_2023.
PATRICi18911617. VBIBacCer120424_1978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000227 Genomic DNA. Translation: ACM12451.1 .
RefSeqi YP_002529740.1. NC_011969.1.

3D structure databases

ProteinModelPortali B9IY25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 361100.BCQ_2023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM12451 ; ACM12451 ; BCQ_2023 .
GeneIDi 7377260.
KEGGi bcq:BCQ_2023.
PATRICi 18911617. VBIBacCer120424_1978.

Phylogenomic databases

eggNOGi COG1902.
HOGENOMi HOG000116232.
KOi K00356.
OMAi PWLGKHG.
OrthoDBi EOG60PHD0.

Enzyme and pathway databases

BioCyci BCER361100:GJ7M-2010-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01614. NamA.
InterProi IPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications."
    Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q.
    J. Bacteriol. 191:1120-1121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Q1.

Entry informationi

Entry nameiNAMA_BACCQ
AccessioniPrimary (citable) accession number: B9IY25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3