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B9IY25

- NAMA_BACCQ

UniProt

B9IY25 - NAMA_BACCQ

Protein

NADPH dehydrogenase

Gene

namA

Organism
Bacillus cereus (strain Q1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

    Catalytic activityi

    NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei215 – 2151FMNUniRule annotation
    Binding sitei308 – 3081FMNUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 275FMNUniRule annotation

    GO - Molecular functioni

    1. FMN binding Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP
    3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
    4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
    5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Detoxification

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    BioCyciBCER361100:GJ7M-2010-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
    Gene namesi
    Name:namAUniRule annotation
    Ordered Locus Names:BCQ_2023
    OrganismiBacillus cereus (strain Q1)
    Taxonomic identifieri361100 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000441: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345NADPH dehydrogenasePRO_1000185863Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi361100.BCQ_2023.

    Structurei

    3D structure databases

    ProteinModelPortaliB9IY25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1902.
    HOGENOMiHOG000116232.
    KOiK00356.
    OMAiPWLGKHG.
    OrthoDBiEOG60PHD0.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01614. NamA.
    InterProiIPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view]
    PfamiPF00724. Oxidored_FMN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9IY25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYKLFSPYT IKDVTLKNRI VMSPMCMYSS KNEDGQITNF HLIHYGTRAA    50
    GQVGLVMIEA TAVLPEGRIS NKDLGIWDDS LIEGLHKATT FIHDNGAKAA 100
    IQLAHAGRKA ELETDALAPS AIPFNETMKM PIEMSKHQIK DTVLAFQQAA 150
    VRSKQAGFDV IEIHGAHGYL INEFLSPLTN KRTDEYGGSP ENRYRFLREI 200
    IESINEVWNG PLFVRISAND YHPDGLTVQD YVQYTKWMKE QGVDLIDCSS 250
    GAVVPARIDV YPGYQVQYAK HIKEHANIAT GAVGLITTGA QAEQILNNNE 300
    ADLIFIGREL LRNPYFPRIA ANELGFELEE PYQYERAPGK ISTNK 345
    Length:345
    Mass (Da):38,605
    Last modified:March 24, 2009 - v1
    Checksum:iAF0F3C5C34479A44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000227 Genomic DNA. Translation: ACM12451.1.
    RefSeqiYP_002529740.1. NC_011969.1.

    Genome annotation databases

    EnsemblBacteriaiACM12451; ACM12451; BCQ_2023.
    GeneIDi7377260.
    KEGGibcq:BCQ_2023.
    PATRICi18911617. VBIBacCer120424_1978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000227 Genomic DNA. Translation: ACM12451.1 .
    RefSeqi YP_002529740.1. NC_011969.1.

    3D structure databases

    ProteinModelPortali B9IY25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 361100.BCQ_2023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM12451 ; ACM12451 ; BCQ_2023 .
    GeneIDi 7377260.
    KEGGi bcq:BCQ_2023.
    PATRICi 18911617. VBIBacCer120424_1978.

    Phylogenomic databases

    eggNOGi COG1902.
    HOGENOMi HOG000116232.
    KOi K00356.
    OMAi PWLGKHG.
    OrthoDBi EOG60PHD0.

    Enzyme and pathway databases

    BioCyci BCER361100:GJ7M-2010-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01614. NamA.
    InterProi IPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view ]
    Pfami PF00724. Oxidored_FMN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications."
      Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q.
      J. Bacteriol. 191:1120-1121(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Q1.

    Entry informationi

    Entry nameiNAMA_BACCQ
    AccessioniPrimary (citable) accession number: B9IY25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3