B9IVW6 (PYRB_BACCQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BCQ_3675

Organism

Bacillus cereus (strain Q1) [Complete proteome] [HAMAP]

Taxonomic identifier

361100 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000116125

Sequences

	Sequence		Length	Mass (Da)
	B9IVW6 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 7E4FE09447EE773E	FASTA	304	34,722
	10 20 30 40 50 60 MSHLLTMSEL SEVEISEILK DAEDFANGKE SKTTEQTFVA NLFFENSTRT RFSFEVAEKR 70 80 90 100 110 120 LGLDVLNFSA DASSVQKGET LYDTIRTLES IGTKAVVIRH EQDRYFDELK DQVNIPILNA 130 140 150 160 170 180 GDGCGNHPTQ CLLDLLTIKQ EFGRFEGLKI AIVGDVRHSR VARSNAEALT KLGATIYFAS 190 200 210 220 230 240 PEEWKDEDNT FGTYKPLDEL VPEVDVMMLL RVQHERHDHY ETDIMKEYHE KHGLTVEREK 250 260 270 280 290 300 RMKEGSIIMH PAPVNRDVEI ASELVECERS RIFKQMENGV YVRMAVLKRA LPNVLGGMKH ELFV

References

[1]

"Complete genome sequence of the extremophilic Bacillus cereus strain Q1 with industrial applications." Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X., Xue Y., Zhu Y., Jin Q. J. Bacteriol. 191:1120-1121(2009) [PubMed: 19060151] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Q1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000227 Genomic DNA. Translation: ACM14103.1.
RefSeq	YP_002531392.1. NC_011969.1.
3D structure databases
ProteinModelPortal	B9IVW6.
ModBase	Search...
Protein-protein interaction databases
STRING	B9IVW6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000096875; EBBACP00000093516; EBBACG00000096868.
GeneID	7375869.
GenomeReviews	Gene locus BCQ_3675 in contig CP000227_GR.
KEGG	bcq:BCQ_3675.
PATRIC	18915074. VBIBacCer120424_3705.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002562.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACCQ

Accession

Primary (citable) accession number: B9IVW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program