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Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Gene

POPTR_0005s09200g

Organism
Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial (POPTR_0007s07430g), Dihydroorotate dehydrogenase (quinone), mitochondrial (POPTR_007G074200v3), Dihydroorotate dehydrogenase (quinone), mitochondrial (POPTR_0005s09200g)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route), the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrialUniRule annotation (EC:1.3.5.2UniRule annotation)
Short name:
DHOdehaseUniRule annotation
Gene namesi
ORF Names:POPTR_0005s09200gImported, POPTR_005G089700v3Imported
OrganismiPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)Imported
Taxonomic identifieri3694 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus
Proteomesi
  • UP000006729 Componentsi: Chromosome 5, Linkage group LGV

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 68HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiB9H5P7 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3694.POPTR_0005s09200.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 440DHO_dhInterPro annotationAdd BLAST319

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili282 – 302Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1436 Eukaryota
COG0167 LUCA
HOGENOMiHOG000225103
InParanoidiB9H5P7
KOiK00254
OMAiEAHHVGT
OrthoDBiEOG09360951

Family and domain databases

CDDicd04738 DHOD_2_like, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00225 DHO_dh_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR005719 Dihydroorotate_DH_2
IPR001295 Dihydroorotate_DH_CS
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
TIGRFAMsiTIGR01036 pyrD_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00911 DHODEHASE_1, 1 hit
PS00912 DHODEHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9H5P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRASRRLL KDFLLKRVTS TPVSSVRHFS SSSSSETAPK IPHFSKKGRL
60 70 80 90 100
LTGATIGLVI AGGAYVSTVD EATFCGWLFN ATKLVNPFFA LLDAEFAHKL
110 120 130 140 150
AVSAAARGWV PREKRPDPSV LGLEVWGRKF SNPIGLAAGF DKNAEAIDGL
160 170 180 190 200
LGLGFGFVEV GSVTPVPQEG NPKPRIFRLR QEGAIINRCG FNSEGIVAVA
210 220 230 240 250
KRLGAQHGKR KLDETSSASS TSNNDVKHGG KAGPGILGVN LGKNKTSEDA
260 270 280 290 300
AADYVQGVHS LSQYSDYLVI NVSSPNTPGL RMLQGRKQLK DLVKKVQAAR
310 320 330 340 350
DEMQWGEEGP PPLLVKIAPD LSKEDLEDIA AVALALRLDG LIISNTTISR
360 370 380 390 400
PDSVNKSPVA EETGGLSGKP LLNLSTNILK EMFILTRGKI PLIGCGGVFS
410 420 430 440 450
GEDAYKKVRA GATLVQLYTG FAYGGPALIP RIKAELAECL ERDGFKSISE

AVGADYR
Length:457
Mass (Da):48,708
Last modified:March 24, 2009 - v1
Checksum:i9FA9241C57DA932C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000341 Genomic DNA Translation: EEE93370.1
CM009294 Genomic DNA Translation: PNT35718.1
RefSeqiXP_002306374.1, XM_002306338.2

Genome annotation databases

EnsemblPlantsiPOPTR_0005s09200.1; POPTR_0005s09200.1; POPTR_0005s09200
GeneIDi7486362
GrameneiPOPTR_0005s09200.1; POPTR_0005s09200.1; POPTR_0005s09200
KEGGipop:POPTR_0005s09200g

Similar proteinsi

Entry informationi

Entry nameiB9H5P7_POPTR
AccessioniPrimary (citable) accession number: B9H5P7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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