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B9GH07

- B9GH07_POPTR

UniProt

B9GH07 - B9GH07_POPTR

Protein

Histidinol dehydrogenase, chloroplastic

Gene

POPTR_0001s46960g

Organism
Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADUniRule annotation
    Binding sitei189 – 1891NADUniRule annotation
    Binding sitei212 – 2121NADUniRule annotation
    Binding sitei238 – 2381Substrate
    Metal bindingi260 – 2601ZincUniRule annotation
    Binding sitei260 – 2601Substrate
    Metal bindingi263 – 2631ZincUniRule annotation
    Binding sitei263 – 2631Substrate
    Active sitei328 – 3281Proton acceptorUniRule annotation
    Active sitei329 – 3291Proton acceptorUniRule annotation
    Binding sitei329 – 3291Substrate
    Metal bindingi362 – 3621ZincUniRule annotation
    Binding sitei362 – 3621Substrate
    Binding sitei416 – 4161Substrate
    Metal bindingi421 – 4211ZincUniRule annotation
    Binding sitei421 – 4211SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase, chloroplasticUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    ORF Names:POPTR_0001s46960gImported
    OrganismiPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)Imported
    Taxonomic identifieri3694 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus
    ProteomesiUP000006729: Unassembled WGS sequence

    Subcellular locationi

    Plastidchloroplast UniRule annotation

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    ChloroplastUniRule annotation, Plastid

    Interactioni

    Protein-protein interaction databases

    STRINGi3694.eugene3.00013048.

    Structurei

    3D structure databases

    ProteinModelPortaliB9GH07.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiFQEITRE.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9GH07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCAMKSYRLS ELNNSEVESL KARPRIDFSS IFGIVNPIVD DVRQRGDAAV    50
    KDYTSRFDKV KLDKIVENVS ELPDPELDAT VKEAFDVAYN NIYAFHLAQK 100
    SVEKSVETMK GVRCKRVARS ISSVGLYVPG GTAVLPSTAL MLAIPAQIAG 150
    CKTVVLATPP AQDGSICKEV LYCAKKAGVT HILKAGGAQA ISAMAWGTES 200
    CPKAEKIFGP GNQYVTAAKM ILQNSEAMIS IDMPAGPSEV LVIADRYASP 250
    VHIAADLLSQ AEHGPDSQVV LVVAGDGVDM KAIEEEISKQ CQSLPRGEYA 300
    SKALSHSFTV FARDMVEAVS FSNLYAPEHL IINVKEAEKW ESFIENAGSV 350
    FLGPWTPESV GDYASGTNHV LPTYGYARMY GGVSLDSFQK YMTVQSLTEE 400
    GLRKLGPYVA TMAEVEGLDA HKRAVTLRLQ DIEARQVSNT R 441
    Length:441
    Mass (Da):47,768
    Last modified:March 24, 2009 - v1
    Checksum:iE10AFE0C50A7EAF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000337 Genomic DNA. Translation: EEE85368.1.
    RefSeqiXP_002300563.1. XM_002300527.2.

    Genome annotation databases

    EnsemblPlantsiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960.
    GeneIDi7480422.
    KEGGipop:POPTR_0001s46960g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000337 Genomic DNA. Translation: EEE85368.1 .
    RefSeqi XP_002300563.1. XM_002300527.2.

    3D structure databases

    ProteinModelPortali B9GH07.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3694.eugene3.00013048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi POPTR_0001s46960.1 ; POPTR_0001s46960.1 ; POPTR_0001s46960 .
    GeneIDi 7480422.
    KEGGi pop:POPTR_0001s46960g.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi FQEITRE.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)."
      Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I., Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J., Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W., Brun A.
      , Brunner A., Busov V., Campbell M., Carlson J., Chalot M., Chapman J., Chen G.-L., Cooper D., Coutinho P.M., Couturier J., Covert S., Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A., dePamphilis C.W., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J., Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A., Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B., Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S., Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjaervi J., Karlsson J., Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F., Leebens-Mack J., Leple J.-C., Locascio P., Lou Y., Lucas S., Martin F., Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O., Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J., Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J., Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A., Tsai C.-J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S., Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y., Rokhsar D.S.
      Science 313:1596-1604(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. NisquallyImported.

    Entry informationi

    Entry nameiB9GH07_POPTR
    AccessioniPrimary (citable) accession number: B9GH07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3