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Protein

Histidinol dehydrogenase, chloroplastic

Gene

POPTR_0001s46960g

Organism
Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Imidazoleglycerol-phosphate dehydratase (POPTR_0010s09790g)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase, chloroplastic (POPTR_0001s46960g)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127NADUniRule annotation1
Binding sitei189NADUniRule annotation1
Binding sitei212NADUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Metal bindingi260ZincUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Metal bindingi263ZincUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei328Proton acceptorUniRule annotation1
Active sitei329Proton acceptorUniRule annotation1
Binding sitei329SubstrateUniRule annotation1
Metal bindingi362ZincUniRule annotation1
Binding sitei362SubstrateUniRule annotation1
Binding sitei416SubstrateUniRule annotation1
Metal bindingi421ZincUniRule annotation1
Binding sitei421SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplasticUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
ORF Names:POPTR_0001s46960gImported
OrganismiPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)Imported
Taxonomic identifieri3694 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus
Proteomesi
  • UP000006729 Componenti: Linkage group LGI

Subcellular locationi

  • Plastidchloroplast UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ChloroplastUniRule annotation, Plastid

Interactioni

Protein-protein interaction databases

STRINGi3694.POPTR_0001s46960.1.

Structurei

3D structure databases

ProteinModelPortaliB9GH07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2697. Eukaryota.
COG0141. LUCA.
HOGENOMiHOG000243914.
InParanoidiB9GH07.
KOiK00013.
OMAiWRGIITP.
OrthoDBiEOG09360BMC.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9GH07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAMKSYRLS ELNNSEVESL KARPRIDFSS IFGIVNPIVD DVRQRGDAAV
60 70 80 90 100
KDYTSRFDKV KLDKIVENVS ELPDPELDAT VKEAFDVAYN NIYAFHLAQK
110 120 130 140 150
SVEKSVETMK GVRCKRVARS ISSVGLYVPG GTAVLPSTAL MLAIPAQIAG
160 170 180 190 200
CKTVVLATPP AQDGSICKEV LYCAKKAGVT HILKAGGAQA ISAMAWGTES
210 220 230 240 250
CPKAEKIFGP GNQYVTAAKM ILQNSEAMIS IDMPAGPSEV LVIADRYASP
260 270 280 290 300
VHIAADLLSQ AEHGPDSQVV LVVAGDGVDM KAIEEEISKQ CQSLPRGEYA
310 320 330 340 350
SKALSHSFTV FARDMVEAVS FSNLYAPEHL IINVKEAEKW ESFIENAGSV
360 370 380 390 400
FLGPWTPESV GDYASGTNHV LPTYGYARMY GGVSLDSFQK YMTVQSLTEE
410 420 430 440
GLRKLGPYVA TMAEVEGLDA HKRAVTLRLQ DIEARQVSNT R
Length:441
Mass (Da):47,768
Last modified:March 24, 2009 - v1
Checksum:iE10AFE0C50A7EAF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000337 Genomic DNA. Translation: EEE85368.1.
RefSeqiXP_002300563.1. XM_002300527.2.

Genome annotation databases

EnsemblPlantsiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960.
GeneIDi7480422.
GrameneiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960.
KEGGipop:POPTR_0001s46960g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000337 Genomic DNA. Translation: EEE85368.1.
RefSeqiXP_002300563.1. XM_002300527.2.

3D structure databases

ProteinModelPortaliB9GH07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3694.POPTR_0001s46960.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960.
GeneIDi7480422.
GrameneiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960.
KEGGipop:POPTR_0001s46960g.

Phylogenomic databases

eggNOGiKOG2697. Eukaryota.
COG0141. LUCA.
HOGENOMiHOG000243914.
InParanoidiB9GH07.
KOiK00013.
OMAiWRGIITP.
OrthoDBiEOG09360BMC.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9GH07_POPTR
AccessioniPrimary (citable) accession number: B9GH07
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.