Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B9FK36

- ACC2_ORYSJ

UniProt

B9FK36 - ACC2_ORYSJ

Protein

Acetyl-CoA carboxylase 2

Gene

ACC2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 2 (21 Sep 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.By similarity

    Catalytic activityi

    ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
    ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

    Cofactori

    Biotin.By similarity
    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Magnesium or manganese 1PROSITE-ProRule annotation
    Metal bindingi450 – 4501Magnesium or manganese 1PROSITE-ProRule annotation
    Metal bindingi450 – 4501Magnesium or manganese 2PROSITE-ProRule annotation
    Metal bindingi452 – 4521Magnesium or manganese 2PROSITE-ProRule annotation
    Active sitei454 – 4541By similarity
    Binding sitei1818 – 18181Coenzyme ABy similarity
    Binding sitei2119 – 21191Coenzyme ABy similarity
    Binding sitei2121 – 21211Coenzyme ABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi313 – 37058ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. biotin carboxylase activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid elongation Source: EnsemblPlants/Gramene
    2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    3. primary shoot apical meristem specification Source: EnsemblPlants/Gramene
    4. response to cytokinin Source: EnsemblPlants/Gramene
    5. root development Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00655; UER00711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA carboxylase 2 (EC:6.4.1.2)
    Including the following 1 domains:
    Biotin carboxylase (EC:6.3.4.14)
    Gene namesi
    Name:ACC2
    Ordered Locus Names:Os05g0295300, LOC_Os05g22940
    ORF Names:OsJ_17935
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 5

    Organism-specific databases

    GrameneiB9FK36.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. plasma membrane Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23272327Acetyl-CoA carboxylase 2PRO_0000412214Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliB9FK36.
    SMRiB9FK36. Positions 120-640.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 641508Biotin carboxylationAdd
    BLAST
    Domaini287 – 481195ATP-graspPROSITE-ProRule annotationAdd
    BLAST
    Domaini767 – 84175Biotinyl-bindingAdd
    BLAST
    Domaini1594 – 2187594CarboxyltransferaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
    Contains 1 biotin carboxylation domain.Curated
    Contains 1 biotinyl-binding domain.Curated
    Contains 1 carboxyltransferase domain.Curated

    Phylogenomic databases

    eggNOGiCOG0511.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProiIPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9FK36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTHVATLG VGAQAPPRHQ KKSAGTAFVS SGSSRPSYRK NGQRTRSLRE     50
    ESNGGVSDSK KLNHSIRQGL AGIIDLPNDA ASEVDISHGS EDPRGPTVPG 100
    SYQMNGIINE THNGRHASVS KVVEFCTALG GKTPIHSVLV ANNGMAAAKF 150
    MRSVRTWAND TFGSEKAIQL IAMATPEDLR INAEHIRIAD QFVEVPGGTN 200
    NNNYANVQLI VEIAERTGVS AVWPGWGHAS ENPELPDALT AKGIVFLGPP 250
    ASSMHALGDK VGSALIAQAA GVPTLAWSGS HVEVPLECCL DSIPDEMYRK 300
    ACVTTTEEAV ASCQVVGYPA MIKASWGGGG KGIRKVHNDD EVRTLFKQVQ 350
    GEVPGSPIFI MRLAAQSRHL EVQLLCDQYG NVAALHSRDC SVQRRHQKII 400
    EEGPVTVAPR ETVKELEQAA RRLAKAVGYV GAATVEYLYS METGEYYFLE 450
    LNPRLQVEHP VTEWIAEVNL PAAQVAVGMG IPLWQIPEIR RFYGMNHGGG 500
    YDLWRKTAAL ATPFNFDEVD SKWPKGHCVA VRITSEDPDD GFKPTGGKVK 550
    EISFKSKPNV WAYFSVKSGG GIHEFADSQF GHVFAYGTTR SAAITTMALA 600
    LKEVQIRGEI HSNVDYTVDL LNASDFRENK IHTGWLDTRI AMRVQAERPP 650
    WYISVVGGAL YKTVTANTAT VSDYVGYLTK GQIPPKHISL VYTTVALNID 700
    GKKYTIDTVR SGHGSYRLRM NGSTVDANVQ ILCDGGLLMQ LDGNSHVIYA 750
    EEEASGTRLL IDGKTCMLQN DHDPSKLLAE TPCKLLRFLV ADGAHVDADV 800
    PYAEVEVMKM CMPLLSPASG VIHVVMSEGQ AMQAGDLIAR LDLDDPSAVK 850
    RAEPFEDTFP QMGLPIAASG QVHKLCAASL NACRMILAGY EHDIDKVVPE 900
    LVYCLDTPEL PFLQWEELMS VLATRLPRNL KSELEGKYEE YKVKFDSGII 950
    NDFPANMLRV IIEENLACGS EKEKATNERL VEPLMSLLKS YEGGRESHAH 1000
    FVVKSLFEEY LYVEELFSDG IQSDVIERLR LQHSKDLQKV VDIVLSHQSV 1050
    RNKTKLILKL MESLVYPNPA AYRDQLIRFS SLNHKAYYKL ALKASELLEQ 1100
    TKLSELRARI ARSLSELEMF TEESKGLSMH KREIAIKESM EDLVTAPLPV 1150
    EDALISLFDC SDTTVQQRVI ETYIARLYQP HLVKDSIKMK WIESGVIALW 1200
    EFPEGHFDAR NGGAVLGDKR WGAMVIVKSL ESLSMAIRFA LKETSHYTSS 1250
    EGNMMHIALL GADNKMHIIQ ESGDDADRIA KLPLILKDNV TDLHASGVKT 1300
    ISFIVQRDEA RMTMRRTFLW SDEKLSYEEE PILRHVEPPL SALLELDKLK 1350
    VKGYNEMKYT PSRDRQWHIY TLRNTENPKM LHRVFFRTLV RQPSVSNKFS 1400
    SGQIGDMEVG SAEEPLSFTS TSILRSLMTA IEELELHAIR TGHSHMYLHV 1450
    LKEQKLLDLV PVSGNTVLDV GQDEATAYSL LKEMAMKIHE LVGARMHHLS 1500
    VCQWEVKLKL DCDGPASGTW RIVTTNVTSH TCTVDIYREM EDKESRKLVY 1550
    HPATPAAGPL HGVALNNPYQ PLSVIDLKRC SARNNRTTYC YDFPLAFETA 1600
    VRKSWSSSTS GASKGVENAQ CYVKATELVF ADKHGSWGTP LVQMDRPAGL 1650
    NDIGMVAWTL KMSTPEFPSG REIIVVANDI TFRAGSFGPR EDAFFEAVTN 1700
    LACEKKLPLI YLAANSGARI GIADEVKSCF RVGWSDDGSP ERGFQYIYLS 1750
    EEDYARIGTS VIAHKMQLDS GEIRWVIDSV VGKEDGLGVE NIHGSAAIAS 1800
    AYSRAYKETF TLTFVTGRTV GIGAYLARLG IRCIQRLDQP IILTGYSALN 1850
    KLLGREVYSS HMQLGGPKIM ATNGVVHLTV SDDLEGVSNI LRWLSYVPAY 1900
    IGGPLPVTTP LDPPDRPVAY IPENSCDPRA AIRGVDDSQG KWLGGMFDKD 1950
    SFVETFEGWA KTVVTGRAKL GGIPVGVIAV ETQTMMQTIP ADPGQLDSRE 2000
    QSVPRAGQVW FPDSATKTAQ ALLDFNREGL PLFILANWRG FSGGQRDLFE 2050
    GILQAGSTIV ENLRTYNQPA FVYIPMAAEL RGGAWVVVDS KINPDRIECY 2100
    AERTAKGNVL EPQGLIEIKF RSEELQDCMS RLDPTLIDLK AKLEVANKNG 2150
    SADTKSLQEN IEARTKQLMP LYTQIAIRFA ELHDTSLRMA AKGVIKKVVD 2200
    WEESRSFFYK RLRRRISEDV LAKEIRAVAG EQFSHQPAIE LIKKWYSASH 2250
    AAEWDDDDAF VAWMDNPENY KDYIQYLKAQ RVSQSLSSLS DSSSDLQALP 2300
    QGLSMLLDKM DPSRRAQLVE EIRKVLG 2327
    Length:2,327
    Mass (Da):257,716
    Last modified:September 21, 2011 - v2
    Checksum:iC0BE5AA19910D26C
    GO

    Sequence cautioni

    The sequence BAF17025.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EEE63127.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008211 Genomic DNA. Translation: BAF17025.1. Sequence problems.
    CM000142 Genomic DNA. Translation: EEE63127.1. Sequence problems.
    RefSeqiNP_001055111.1. NM_001061646.1.
    UniGeneiOs.14447.

    Genome annotation databases

    GeneIDi4338322.
    KEGGiosa:4338322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008211 Genomic DNA. Translation: BAF17025.1 . Sequence problems.
    CM000142 Genomic DNA. Translation: EEE63127.1 . Sequence problems.
    RefSeqi NP_001055111.1. NM_001061646.1.
    UniGenei Os.14447.

    3D structure databases

    ProteinModelPortali B9FK36.
    SMRi B9FK36. Positions 120-640.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4338322.
    KEGGi osa:4338322.

    Organism-specific databases

    Gramenei B9FK36.

    Phylogenomic databases

    eggNOGi COG0511.

    Enzyme and pathway databases

    UniPathwayi UPA00655 ; UER00711 .

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProi IPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiACC2_ORYSJ
    AccessioniPrimary (citable) accession number: B9FK36
    Secondary accession number(s): Q0DJE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3