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B9FK36

- ACC2_ORYSJ

UniProt

B9FK36 - ACC2_ORYSJ

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Protein

Acetyl-CoA carboxylase 2

Gene

ACC2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Biotin.By similarity
Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Magnesium or manganese 1PROSITE-ProRule annotation
Metal bindingi450 – 4501Magnesium or manganese 1PROSITE-ProRule annotation
Metal bindingi450 – 4501Magnesium or manganese 2PROSITE-ProRule annotation
Metal bindingi452 – 4521Magnesium or manganese 2PROSITE-ProRule annotation
Active sitei454 – 4541By similarity
Binding sitei1818 – 18181Coenzyme ABy similarity
Binding sitei2119 – 21191Coenzyme ABy similarity
Binding sitei2121 – 21211Coenzyme ABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi313 – 37058ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA carboxylase 2 (EC:6.4.1.2)
Including the following 1 domains:
Biotin carboxylase (EC:6.3.4.14)
Gene namesi
Name:ACC2
Ordered Locus Names:Os05g0295300, LOC_Os05g22940
ORF Names:OsJ_17935
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiB9FK36.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23272327Acetyl-CoA carboxylase 2PRO_0000412214Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliB9FK36.
SMRiB9FK36. Positions 120-640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 641508Biotin carboxylationAdd
BLAST
Domaini287 – 481195ATP-graspPROSITE-ProRule annotationAdd
BLAST
Domaini767 – 84175Biotinyl-bindingAdd
BLAST
Domaini1594 – 2187594CarboxyltransferaseAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
Contains 1 biotin carboxylation domain.Curated
Contains 1 biotinyl-binding domain.Curated
Contains 1 carboxyltransferase domain.Curated

Phylogenomic databases

eggNOGiCOG0511.
InParanoidiB9FK36.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9FK36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTHVATLG VGAQAPPRHQ KKSAGTAFVS SGSSRPSYRK NGQRTRSLRE
60 70 80 90 100
ESNGGVSDSK KLNHSIRQGL AGIIDLPNDA ASEVDISHGS EDPRGPTVPG
110 120 130 140 150
SYQMNGIINE THNGRHASVS KVVEFCTALG GKTPIHSVLV ANNGMAAAKF
160 170 180 190 200
MRSVRTWAND TFGSEKAIQL IAMATPEDLR INAEHIRIAD QFVEVPGGTN
210 220 230 240 250
NNNYANVQLI VEIAERTGVS AVWPGWGHAS ENPELPDALT AKGIVFLGPP
260 270 280 290 300
ASSMHALGDK VGSALIAQAA GVPTLAWSGS HVEVPLECCL DSIPDEMYRK
310 320 330 340 350
ACVTTTEEAV ASCQVVGYPA MIKASWGGGG KGIRKVHNDD EVRTLFKQVQ
360 370 380 390 400
GEVPGSPIFI MRLAAQSRHL EVQLLCDQYG NVAALHSRDC SVQRRHQKII
410 420 430 440 450
EEGPVTVAPR ETVKELEQAA RRLAKAVGYV GAATVEYLYS METGEYYFLE
460 470 480 490 500
LNPRLQVEHP VTEWIAEVNL PAAQVAVGMG IPLWQIPEIR RFYGMNHGGG
510 520 530 540 550
YDLWRKTAAL ATPFNFDEVD SKWPKGHCVA VRITSEDPDD GFKPTGGKVK
560 570 580 590 600
EISFKSKPNV WAYFSVKSGG GIHEFADSQF GHVFAYGTTR SAAITTMALA
610 620 630 640 650
LKEVQIRGEI HSNVDYTVDL LNASDFRENK IHTGWLDTRI AMRVQAERPP
660 670 680 690 700
WYISVVGGAL YKTVTANTAT VSDYVGYLTK GQIPPKHISL VYTTVALNID
710 720 730 740 750
GKKYTIDTVR SGHGSYRLRM NGSTVDANVQ ILCDGGLLMQ LDGNSHVIYA
760 770 780 790 800
EEEASGTRLL IDGKTCMLQN DHDPSKLLAE TPCKLLRFLV ADGAHVDADV
810 820 830 840 850
PYAEVEVMKM CMPLLSPASG VIHVVMSEGQ AMQAGDLIAR LDLDDPSAVK
860 870 880 890 900
RAEPFEDTFP QMGLPIAASG QVHKLCAASL NACRMILAGY EHDIDKVVPE
910 920 930 940 950
LVYCLDTPEL PFLQWEELMS VLATRLPRNL KSELEGKYEE YKVKFDSGII
960 970 980 990 1000
NDFPANMLRV IIEENLACGS EKEKATNERL VEPLMSLLKS YEGGRESHAH
1010 1020 1030 1040 1050
FVVKSLFEEY LYVEELFSDG IQSDVIERLR LQHSKDLQKV VDIVLSHQSV
1060 1070 1080 1090 1100
RNKTKLILKL MESLVYPNPA AYRDQLIRFS SLNHKAYYKL ALKASELLEQ
1110 1120 1130 1140 1150
TKLSELRARI ARSLSELEMF TEESKGLSMH KREIAIKESM EDLVTAPLPV
1160 1170 1180 1190 1200
EDALISLFDC SDTTVQQRVI ETYIARLYQP HLVKDSIKMK WIESGVIALW
1210 1220 1230 1240 1250
EFPEGHFDAR NGGAVLGDKR WGAMVIVKSL ESLSMAIRFA LKETSHYTSS
1260 1270 1280 1290 1300
EGNMMHIALL GADNKMHIIQ ESGDDADRIA KLPLILKDNV TDLHASGVKT
1310 1320 1330 1340 1350
ISFIVQRDEA RMTMRRTFLW SDEKLSYEEE PILRHVEPPL SALLELDKLK
1360 1370 1380 1390 1400
VKGYNEMKYT PSRDRQWHIY TLRNTENPKM LHRVFFRTLV RQPSVSNKFS
1410 1420 1430 1440 1450
SGQIGDMEVG SAEEPLSFTS TSILRSLMTA IEELELHAIR TGHSHMYLHV
1460 1470 1480 1490 1500
LKEQKLLDLV PVSGNTVLDV GQDEATAYSL LKEMAMKIHE LVGARMHHLS
1510 1520 1530 1540 1550
VCQWEVKLKL DCDGPASGTW RIVTTNVTSH TCTVDIYREM EDKESRKLVY
1560 1570 1580 1590 1600
HPATPAAGPL HGVALNNPYQ PLSVIDLKRC SARNNRTTYC YDFPLAFETA
1610 1620 1630 1640 1650
VRKSWSSSTS GASKGVENAQ CYVKATELVF ADKHGSWGTP LVQMDRPAGL
1660 1670 1680 1690 1700
NDIGMVAWTL KMSTPEFPSG REIIVVANDI TFRAGSFGPR EDAFFEAVTN
1710 1720 1730 1740 1750
LACEKKLPLI YLAANSGARI GIADEVKSCF RVGWSDDGSP ERGFQYIYLS
1760 1770 1780 1790 1800
EEDYARIGTS VIAHKMQLDS GEIRWVIDSV VGKEDGLGVE NIHGSAAIAS
1810 1820 1830 1840 1850
AYSRAYKETF TLTFVTGRTV GIGAYLARLG IRCIQRLDQP IILTGYSALN
1860 1870 1880 1890 1900
KLLGREVYSS HMQLGGPKIM ATNGVVHLTV SDDLEGVSNI LRWLSYVPAY
1910 1920 1930 1940 1950
IGGPLPVTTP LDPPDRPVAY IPENSCDPRA AIRGVDDSQG KWLGGMFDKD
1960 1970 1980 1990 2000
SFVETFEGWA KTVVTGRAKL GGIPVGVIAV ETQTMMQTIP ADPGQLDSRE
2010 2020 2030 2040 2050
QSVPRAGQVW FPDSATKTAQ ALLDFNREGL PLFILANWRG FSGGQRDLFE
2060 2070 2080 2090 2100
GILQAGSTIV ENLRTYNQPA FVYIPMAAEL RGGAWVVVDS KINPDRIECY
2110 2120 2130 2140 2150
AERTAKGNVL EPQGLIEIKF RSEELQDCMS RLDPTLIDLK AKLEVANKNG
2160 2170 2180 2190 2200
SADTKSLQEN IEARTKQLMP LYTQIAIRFA ELHDTSLRMA AKGVIKKVVD
2210 2220 2230 2240 2250
WEESRSFFYK RLRRRISEDV LAKEIRAVAG EQFSHQPAIE LIKKWYSASH
2260 2270 2280 2290 2300
AAEWDDDDAF VAWMDNPENY KDYIQYLKAQ RVSQSLSSLS DSSSDLQALP
2310 2320
QGLSMLLDKM DPSRRAQLVE EIRKVLG
Length:2,327
Mass (Da):257,716
Last modified:September 21, 2011 - v2
Checksum:iC0BE5AA19910D26C
GO

Sequence cautioni

The sequence BAF17025.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EEE63127.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008211 Genomic DNA. Translation: BAF17025.1. Sequence problems.
CM000142 Genomic DNA. Translation: EEE63127.1. Sequence problems.
RefSeqiNP_001055111.1. NM_001061646.1.
UniGeneiOs.14447.

Genome annotation databases

GeneIDi4338322.
KEGGiosa:4338322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008211 Genomic DNA. Translation: BAF17025.1 . Sequence problems.
CM000142 Genomic DNA. Translation: EEE63127.1 . Sequence problems.
RefSeqi NP_001055111.1. NM_001061646.1.
UniGenei Os.14447.

3D structure databases

ProteinModelPortali B9FK36.
SMRi B9FK36. Positions 120-640.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4338322.
KEGGi osa:4338322.

Organism-specific databases

Gramenei B9FK36.

Phylogenomic databases

eggNOGi COG0511.
InParanoidi B9FK36.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProi IPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiACC2_ORYSJ
AccessioniPrimary (citable) accession number: B9FK36
Secondary accession number(s): Q0DJE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3