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B9EKY4

- B9EKY4_MOUSE

UniProt

B9EKY4 - B9EKY4_MOUSE

Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei530 – 5301Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: InterPro
    3. fibroblast growth factor binding Source: MGI
    4. protein binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. axonogenesis Source: MGI
    3. bone development Source: MGI
    4. bone mineralization Source: MGI
    5. bone morphogenesis Source: MGI
    6. branch elongation involved in salivary gland morphogenesis Source: MGI
    7. branching involved in labyrinthine layer morphogenesis Source: MGI
    8. branching involved in prostate gland morphogenesis Source: MGI
    9. branching involved in salivary gland morphogenesis Source: MGI
    10. branching morphogenesis of a nerve Source: MGI
    11. bud elongation involved in lung branching Source: MGI
    12. cell-cell signaling Source: MGI
    13. cell fate commitment Source: MGI
    14. coronal suture morphogenesis Source: MGI
    15. digestive tract development Source: MGI
    16. embryonic cranial skeleton morphogenesis Source: InterPro
    17. embryonic digestive tract morphogenesis Source: MGI
    18. embryonic organ development Source: MGI
    19. embryonic organ morphogenesis Source: MGI
    20. embryonic pattern specification Source: MGI
    21. endodermal digestive tract morphogenesis Source: MGI
    22. epidermis morphogenesis Source: MGI
    23. epithelial cell differentiation Source: MGI
    24. epithelial cell proliferation Source: MGI
    25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
    26. epithelial tube branching involved in lung morphogenesis Source: MGI
    27. fibroblast growth factor receptor signaling pathway Source: MGI
    28. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
    29. gland morphogenesis Source: MGI
    30. hair follicle morphogenesis Source: MGI
    31. inner ear morphogenesis Source: MGI
    32. in utero embryonic development Source: MGI
    33. lacrimal gland development Source: MGI
    34. lateral sprouting from an epithelium Source: MGI
    35. lens fiber cell development Source: MGI
    36. limb bud formation Source: MGI
    37. lung alveolus development Source: MGI
    38. lung-associated mesenchyme development Source: MGI
    39. lung development Source: MGI
    40. lung lobe morphogenesis Source: MGI
    41. mammary gland bud formation Source: MGI
    42. membranous septum morphogenesis Source: MGI
    43. mesenchymal cell differentiation Source: MGI
    44. mesenchymal cell differentiation involved in lung development Source: MGI
    45. mesenchymal cell proliferation involved in lung development Source: MGI
    46. midbrain development Source: MGI
    47. morphogenesis of embryonic epithelium Source: MGI
    48. multicellular organism growth Source: MGI
    49. negative regulation of cell proliferation Source: MGI
    50. negative regulation of mitosis Source: MGI
    51. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    52. neuromuscular junction development Source: MGI
    53. odontogenesis Source: MGI
    54. organ growth Source: MGI
    55. organ morphogenesis Source: MGI
    56. otic vesicle formation Source: MGI
    57. outflow tract septum morphogenesis Source: MGI
    58. positive regulation of canonical Wnt signaling pathway Source: MGI
    59. positive regulation of cardiac muscle cell proliferation Source: MGI
    60. positive regulation of cell division Source: MGI
    61. positive regulation of cell proliferation Source: MGI
    62. positive regulation of epithelial cell proliferation Source: MGI
    63. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
    64. positive regulation of ERK1 and ERK2 cascade Source: MGI
    65. positive regulation of mesenchymal cell proliferation Source: MGI
    66. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    67. positive regulation of Wnt signaling pathway Source: MGI
    68. post-embryonic development Source: MGI
    69. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    70. prostate epithelial cord elongation Source: MGI
    71. prostate gland morphogenesis Source: MGI
    72. regulation of branching involved in prostate gland morphogenesis Source: MGI
    73. regulation of cell fate commitment Source: MGI
    74. regulation of cell proliferation Source: MGI
    75. regulation of epithelial cell proliferation Source: MGI
    76. regulation of ERK1 and ERK2 cascade Source: MGI
    77. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    78. regulation of morphogenesis of a branching structure Source: MGI
    79. regulation of multicellular organism growth Source: MGI
    80. regulation of smoothened signaling pathway Source: MGI
    81. regulation of smooth muscle cell differentiation Source: MGI
    82. reproductive structure development Source: MGI
    83. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
    84. synaptic vesicle transport Source: MGI
    85. ureteric bud development Source: MGI
    86. ventricular cardiac muscle tissue morphogenesis Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196534. Signaling by FGFR2 amplification mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:Fgfr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95523. Fgfr2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiB9EKY4.
    BgeeiB9EKY4.
    GenevestigatoriB9EKY4.

    Structurei

    3D structure databases

    ProteinModelPortaliB9EKY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000263410.
    HOVERGENiHBG000345.
    KOiK05093.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
    PfamiPF07679. I-set. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9EKY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT    50
    TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK 100
    EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCLVENE YGSINHTYHL 150
    DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK 200
    NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED AGEYTCLAGN 250
    SIGISFHSAW LTVLPAPVRE KEITASPDYL EIAIYCIGVF LIACMVVTVI 300
    FCRMKTTTKK PDFSSQPAVH KLTKRIPLRR QVTVSAESSS SMNSNTPLVR 350
    ITTRLSSTAD TPMLAGVSEY ELPEDPKWEF PRDKLTLGKP LGEGCFGQVV 400
    MAEAVGIDKD KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN 450
    IINLLGACTQ DGPLYVIVEY ASKGNLREYL RARRPPGMEY SYDINRVPEE 500
    QMTFKDLVSC TYQLARGMEY LASQKCIHRD LAARNVLVTE NNVMKIADFG 550
    LARDINNIDY YKKTTNGRLP VKWMAPEALF DRVYTHQSDV WSFGVLMWEI 600
    FTLGGSPYPG IPVEELFKLL KEGHRMDKPT NCTNELYMMM RDCWHAVPSQ 650
    RPTFKQLVED LDRILTLTTN EEYLDLTQPL EQYSPSYPDT RSSCSSGDDS 700
    VFSPDPMPYE PCLPQYPHIN GSVKT 725
    Length:725
    Mass (Da):81,491
    Last modified:March 24, 2009 - v1
    Checksum:i65012F8AB36975AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151201 mRNA. Translation: AAI51202.1.
    RefSeqiXP_006507420.1. XM_006507357.1.
    UniGeneiMm.16340.

    Genome annotation databases

    GeneIDi14183.
    KEGGimmu:14183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151201 mRNA. Translation: AAI51202.1 .
    RefSeqi XP_006507420.1. XM_006507357.1.
    UniGenei Mm.16340.

    3D structure databases

    ProteinModelPortali B9EKY4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14183.
    KEGGi mmu:14183.

    Organism-specific databases

    CTDi 2263.
    MGIi MGI:95523. Fgfr2.

    Phylogenomic databases

    HOGENOMi HOG000263410.
    HOVERGENi HBG000345.
    KOi K05093.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196534. Signaling by FGFR2 amplification mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    ChiTaRSi FGFR2. mouse.
    NextBioi 35548132.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B9EKY4.
    Bgeei B9EKY4.
    Genevestigatori B9EKY4.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
    Pfami PF07679. I-set. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB9EKY4_MOUSE
    AccessioniPrimary (citable) accession number: B9EKY4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)