B9EKY4 (B9EKY4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Fibroblast growth factor receptor PIRNR PIRNR000628
EC=2.7.10.1 PIRNR PIRNR000628

Gene names

Name:

Fgfr2 EMBL AAI51202.1 MGI 95523

Organism

Mus musculus (Mouse) EMBL AAI51202.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	725 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS008266
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain SAAS SAAS008266 Repeat SAAS SAAS008266 Transmembrane Transmembrane helix SAAS SAAS008266
Ligand	ATP-binding PIRNR PIRNR000628 SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor PIRNR PIRNR000628 SAAS SAAS008266 Transferase Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS008266
PTM	Phosphoprotein SAAS SAAS008266
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from genetic interaction PubMed 16778080. Source: MGI axonogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI bone mineralization Inferred from mutant phenotype PubMed 12756187. Source: MGI branch elongation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI branching involved in labyrinthine layer morphogenesis Inferred from mutant phenotype PubMed 9435295. Source: MGI branching morphogenesis of a nerve Inferred from mutant phenotype PubMed 17951031. Source: MGI bud elongation involved in lung branching Inferred from mutant phenotype PubMed 16989802. Source: MGI cell fate commitment Inferred from direct assay PubMed 15509736. Source: MGI coronal suture morphogenesis Inferred from mutant phenotype PubMed 19389359. Source: MGI embryonic digestive tract morphogenesis Inferred from mutant phenotype PubMed 16618415PubMed 21550054. Source: MGI embryonic pattern specification Inferred from mutant phenotype PubMed 16618415. Source: MGI endodermal digestive tract morphogenesis Inferred from mutant phenotype PubMed 21550054. Source: MGI epithelial cell proliferation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI fibroblast growth factor receptor signaling pathway involved in mammary gland specification Inferred from mutant phenotype PubMed 16720875. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 14530295. Source: MGI lacrimal gland development Inferred from mutant phenotype PubMed 10821755. Source: MGI lateral sprouting from an epithelium Inferred from mutant phenotype PubMed 12666202. Source: MGI lens fiber cell development Inferred from genetic interaction PubMed 18455718. Source: MGI limb bud formation Inferred from mutant phenotype PubMed 10518547PubMed 9435295. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 16989802. Source: MGI lung lobe morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI lung-associated mesenchyme development Inferred from mutant phenotype PubMed 16989802. Source: MGI mammary gland bud formation Inferred from mutant phenotype PubMed 11782400. Source: MGI membranous septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI mesenchymal cell differentiation involved in lung development Inferred from genetic interaction PubMed 16989802. Source: MGI mesenchymal cell proliferation involved in lung development Inferred from mutant phenotype PubMed 16989802. Source: MGI midbrain development Inferred from genetic interaction PubMed 17687036. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 16989802. Source: MGI negative regulation of cell proliferation Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of mitosis Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI neuromuscular junction development Inferred from mutant phenotype PubMed 17418794. Source: MGI odontogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI organ growth Inferred from mutant phenotype PubMed 16618415. Source: MGI otic vesicle formation Inferred from mutant phenotype PubMed 9435295. Source: MGI outflow tract septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI positive regulation of ERK1 and ERK2 cascade Inferred from genetic interaction PubMed 17202188. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16720875. Source: MGI positive regulation of cardiac muscle cell proliferation Inferred from genetic interaction PubMed 15621532. Source: MGI positive regulation of cell division Inferred from mutant phenotype PubMed 14530295. Source: MGI positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from genetic interaction PubMed 16540513. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 16989802. Source: MGI prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from mutant phenotype PubMed 17215304. Source: MGI prostate epithelial cord elongation Inferred from mutant phenotype PubMed 17215304. Source: MGI regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 17202188. Source: MGI regulation of cell fate commitment Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of multicellular organism growth Inferred from mutant phenotype PubMed 9435295. Source: MGI regulation of smooth muscle cell differentiation Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of smoothened signaling pathway Inferred from mutant phenotype PubMed 16618415. Source: MGI squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Inferred from mutant phenotype PubMed 17215304. Source: MGI synaptic vesicle transport Inferred from mutant phenotype PubMed 17418794. Source: MGI ureteric bud development Inferred from genetic interaction PubMed 16442091. Source: MGI ventricular cardiac muscle tissue morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI
Cellular_component	extracellular region Traceable author statement PubMed 12024206. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay PubMed 15229180PubMed 15944199. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fibroblast growth factor binding Inferred from direct assay PubMed 9435295. Source: MGI fibroblast growth factor-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	530	1	Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

	Sequence		Length	Mass (Da)
	B9EKY4 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 65012F8AB36975AF	FASTA	725	81,491
	10 20 30 40 50 60 MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEGAPYW 70 80 90 100 110 120 TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK EFKQEHRIGG YKVRNQHWSL 130 140 150 160 170 180 IMESVVPSDK GNYTCLVENE YGSINHTYHL DVVERSPHRP ILQAGLPANA STVVGGDVEF 190 200 210 220 230 240 VCKVYSDAQP HIQWIKHVEK NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED 250 260 270 280 290 300 AGEYTCLAGN SIGISFHSAW LTVLPAPVRE KEITASPDYL EIAIYCIGVF LIACMVVTVI 310 320 330 340 350 360 FCRMKTTTKK PDFSSQPAVH KLTKRIPLRR QVTVSAESSS SMNSNTPLVR ITTRLSSTAD 370 380 390 400 410 420 TPMLAGVSEY ELPEDPKWEF PRDKLTLGKP LGEGCFGQVV MAEAVGIDKD KPKEAVTVAV 430 440 450 460 470 480 KMLKDDATEK DLSDLVSEME MMKMIGKHKN IINLLGACTQ DGPLYVIVEY ASKGNLREYL 490 500 510 520 530 540 RARRPPGMEY SYDINRVPEE QMTFKDLVSC TYQLARGMEY LASQKCIHRD LAARNVLVTE 550 560 570 580 590 600 NNVMKIADFG LARDINNIDY YKKTTNGRLP VKWMAPEALF DRVYTHQSDV WSFGVLMWEI 610 620 630 640 650 660 FTLGGSPYPG IPVEELFKLL KEGHRMDKPT NCTNELYMMM RDCWHAVPSQ RPTFKQLVED 670 680 690 700 710 720 LDRILTLTTN EEYLDLTQPL EQYSPSYPDT RSSCSSGDDS VFSPDPMPYE PCLPQYPHIN GSVKT

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI51202.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC151201 mRNA. Translation: AAI51202.1.
IPI	IPI00989007.
UniGene	Mm.16340.
3D structure databases
ProteinModelPortal	B9EKY4.
ModBase	Search...
Protein-protein interaction databases
STRING	B9EKY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:95523. Fgfr2.
Phylogenomic databases
HOGENOM	HOG000263410.
HOVERGEN	HBG000345.
Gene expression databases
ArrayExpress	B9EKY4.
Bgee	B9EKY4.
Genevestigator	B9EKY4.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016248. Tyr_kinase_fibroblast_GF_rcpt. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000628. FGFR. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00408. IGc2. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FGFR2. mouse.
NextBio	35548132.
SOURCE	Search...

Entry information

Entry name

B9EKY4_MOUSE

Accession

Primary (citable) accession number: B9EKY4

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)