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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei530 – 5301Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: MGI
  3. fibroblast growth factor binding Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. axonogenesis Source: MGI
  3. bone development Source: MGI
  4. bone mineralization Source: MGI
  5. bone morphogenesis Source: MGI
  6. branch elongation involved in salivary gland morphogenesis Source: MGI
  7. branching involved in labyrinthine layer morphogenesis Source: MGI
  8. branching involved in prostate gland morphogenesis Source: MGI
  9. branching involved in salivary gland morphogenesis Source: MGI
  10. branching morphogenesis of a nerve Source: MGI
  11. bud elongation involved in lung branching Source: MGI
  12. cell-cell signaling Source: MGI
  13. cell fate commitment Source: MGI
  14. coronal suture morphogenesis Source: MGI
  15. digestive tract development Source: MGI
  16. embryonic cranial skeleton morphogenesis Source: MGI
  17. embryonic digestive tract morphogenesis Source: MGI
  18. embryonic organ development Source: MGI
  19. embryonic organ morphogenesis Source: MGI
  20. embryonic pattern specification Source: MGI
  21. endodermal digestive tract morphogenesis Source: MGI
  22. epidermis morphogenesis Source: MGI
  23. epithelial cell differentiation Source: MGI
  24. epithelial cell proliferation Source: MGI
  25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  26. epithelial tube branching involved in lung morphogenesis Source: MGI
  27. fibroblast growth factor receptor signaling pathway Source: MGI
  28. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  29. gland morphogenesis Source: MGI
  30. hair follicle morphogenesis Source: MGI
  31. inner ear morphogenesis Source: MGI
  32. in utero embryonic development Source: MGI
  33. lacrimal gland development Source: MGI
  34. lateral sprouting from an epithelium Source: MGI
  35. lens fiber cell development Source: MGI
  36. limb bud formation Source: MGI
  37. lung alveolus development Source: MGI
  38. lung-associated mesenchyme development Source: MGI
  39. lung development Source: MGI
  40. lung lobe morphogenesis Source: MGI
  41. mammary gland bud formation Source: MGI
  42. membranous septum morphogenesis Source: MGI
  43. mesenchymal cell differentiation Source: MGI
  44. mesenchymal cell differentiation involved in lung development Source: MGI
  45. mesenchymal cell proliferation involved in lung development Source: MGI
  46. midbrain development Source: MGI
  47. morphogenesis of embryonic epithelium Source: MGI
  48. multicellular organism growth Source: MGI
  49. negative regulation of cell proliferation Source: MGI
  50. negative regulation of mitotic nuclear division Source: MGI
  51. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  52. neuromuscular junction development Source: MGI
  53. odontogenesis Source: MGI
  54. organ growth Source: MGI
  55. organ morphogenesis Source: MGI
  56. otic vesicle formation Source: MGI
  57. outflow tract septum morphogenesis Source: MGI
  58. peptidyl-tyrosine phosphorylation Source: MGI
  59. positive regulation of canonical Wnt signaling pathway Source: MGI
  60. positive regulation of cardiac muscle cell proliferation Source: MGI
  61. positive regulation of cell division Source: MGI
  62. positive regulation of cell proliferation Source: MGI
  63. positive regulation of epithelial cell proliferation Source: MGI
  64. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  65. positive regulation of ERK1 and ERK2 cascade Source: MGI
  66. positive regulation of MAPK cascade Source: MGI
  67. positive regulation of mesenchymal cell proliferation Source: MGI
  68. positive regulation of phospholipase activity Source: MGI
  69. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  70. positive regulation of Wnt signaling pathway Source: MGI
  71. post-embryonic development Source: MGI
  72. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  73. prostate epithelial cord elongation Source: MGI
  74. prostate gland morphogenesis Source: MGI
  75. protein autophosphorylation Source: MGI
  76. regulation of branching involved in prostate gland morphogenesis Source: MGI
  77. regulation of cell fate commitment Source: MGI
  78. regulation of cell proliferation Source: MGI
  79. regulation of epithelial cell proliferation Source: MGI
  80. regulation of ERK1 and ERK2 cascade Source: MGI
  81. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  82. regulation of morphogenesis of a branching structure Source: MGI
  83. regulation of multicellular organism growth Source: MGI
  84. regulation of smoothened signaling pathway Source: MGI
  85. regulation of smooth muscle cell differentiation Source: MGI
  86. reproductive structure development Source: MGI
  87. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  88. synaptic vesicle transport Source: MGI
  89. ureteric bud development Source: MGI
  90. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_302384. Signaling by FGFR2 amplification mutants.
REACT_312401. FGFR2c ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular region Source: MGI
  5. integral component of plasma membrane Source: MGI
  6. intracellular membrane-bounded organelle Source: MGI
  7. nucleoplasm Source: MGI
  8. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

BgeeiB9EKY4.
ExpressionAtlasiB9EKY4. baseline and differential.
GenevestigatoriB9EKY4.

Structurei

3D structure databases

ProteinModelPortaliB9EKY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000263410.
HOVERGENiHBG000345.
KOiK05093.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EKY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK
110 120 130 140 150
EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCLVENE YGSINHTYHL
160 170 180 190 200
DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK
210 220 230 240 250
NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED AGEYTCLAGN
260 270 280 290 300
SIGISFHSAW LTVLPAPVRE KEITASPDYL EIAIYCIGVF LIACMVVTVI
310 320 330 340 350
FCRMKTTTKK PDFSSQPAVH KLTKRIPLRR QVTVSAESSS SMNSNTPLVR
360 370 380 390 400
ITTRLSSTAD TPMLAGVSEY ELPEDPKWEF PRDKLTLGKP LGEGCFGQVV
410 420 430 440 450
MAEAVGIDKD KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN
460 470 480 490 500
IINLLGACTQ DGPLYVIVEY ASKGNLREYL RARRPPGMEY SYDINRVPEE
510 520 530 540 550
QMTFKDLVSC TYQLARGMEY LASQKCIHRD LAARNVLVTE NNVMKIADFG
560 570 580 590 600
LARDINNIDY YKKTTNGRLP VKWMAPEALF DRVYTHQSDV WSFGVLMWEI
610 620 630 640 650
FTLGGSPYPG IPVEELFKLL KEGHRMDKPT NCTNELYMMM RDCWHAVPSQ
660 670 680 690 700
RPTFKQLVED LDRILTLTTN EEYLDLTQPL EQYSPSYPDT RSSCSSGDDS
710 720
VFSPDPMPYE PCLPQYPHIN GSVKT
Length:725
Mass (Da):81,491
Last modified:March 23, 2009 - v1
Checksum:i65012F8AB36975AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151201 mRNA. Translation: AAI51202.1.
RefSeqiXP_006507420.1. XM_006507357.2.
UniGeneiMm.16340.

Genome annotation databases

GeneIDi14183.
KEGGimmu:14183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151201 mRNA. Translation: AAI51202.1.
RefSeqiXP_006507420.1. XM_006507357.2.
UniGeneiMm.16340.

3D structure databases

ProteinModelPortaliB9EKY4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14183.
KEGGimmu:14183.

Organism-specific databases

CTDi2263.
MGIiMGI:95523. Fgfr2.

Phylogenomic databases

HOGENOMiHOG000263410.
HOVERGENiHBG000345.
KOiK05093.

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_302384. Signaling by FGFR2 amplification mutants.
REACT_312401. FGFR2c ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Miscellaneous databases

ChiTaRSiFgfr2. mouse.
NextBioi35548132.
SOURCEiSearch...

Gene expression databases

BgeeiB9EKY4.
ExpressionAtlasiB9EKY4. baseline and differential.
GenevestigatoriB9EKY4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB9EKY4_MOUSE
AccessioniPrimary (citable) accession number: B9EKY4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2009
Last sequence update: March 23, 2009
Last modified: March 31, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.