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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei530Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei279 – 301HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB9EKY4.

Structurei

3D structure databases

ProteinModelPortaliB9EKY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 151Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST110
Domaini160 – 262Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST103
Domaini385 – 674Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000263410.
HOVERGENiHBG000345.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PANTHERiPTHR24416:SF468. PTHR24416:SF468. 1 hit.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

B9EKY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK
110 120 130 140 150
EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCLVENE YGSINHTYHL
160 170 180 190 200
DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK
210 220 230 240 250
NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED AGEYTCLAGN
260 270 280 290 300
SIGISFHSAW LTVLPAPVRE KEITASPDYL EIAIYCIGVF LIACMVVTVI
310 320 330 340 350
FCRMKTTTKK PDFSSQPAVH KLTKRIPLRR QVTVSAESSS SMNSNTPLVR
360 370 380 390 400
ITTRLSSTAD TPMLAGVSEY ELPEDPKWEF PRDKLTLGKP LGEGCFGQVV
410 420 430 440 450
MAEAVGIDKD KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN
460 470 480 490 500
IINLLGACTQ DGPLYVIVEY ASKGNLREYL RARRPPGMEY SYDINRVPEE
510 520 530 540 550
QMTFKDLVSC TYQLARGMEY LASQKCIHRD LAARNVLVTE NNVMKIADFG
560 570 580 590 600
LARDINNIDY YKKTTNGRLP VKWMAPEALF DRVYTHQSDV WSFGVLMWEI
610 620 630 640 650
FTLGGSPYPG IPVEELFKLL KEGHRMDKPT NCTNELYMMM RDCWHAVPSQ
660 670 680 690 700
RPTFKQLVED LDRILTLTTN EEYLDLTQPL EQYSPSYPDT RSSCSSGDDS
710 720
VFSPDPMPYE PCLPQYPHIN GSVKT
Length:725
Mass (Da):81,491
Last modified:March 24, 2009 - v1
Checksum:i65012F8AB36975AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151201 mRNA. Translation: AAI51202.1.
RefSeqiXP_006507420.1. XM_006507357.3.
UniGeneiMm.16340.

Genome annotation databases

GeneIDi14183.

Similar proteinsi

Entry informationi

Entry nameiB9EKY4_MOUSE
AccessioniPrimary (citable) accession number: B9EKY4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)