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Protein
Submitted name:

TRAF2 and NCK interacting kinase

Gene

Tnik

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TRAF2 and NCK interacting kinaseImported
Submitted name:
Traf2 and NCK-interacting protein kinaseImported
Gene namesi
Name:TnikImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916264. Tnik.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 289265Protein kinaseInterPro annotationAdd
BLAST
Domaini1039 – 1326288CNHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili366 – 506141Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG036506.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EKN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTG DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLIKNT KGNTLKEEWI AYICREILRG LSHLHQHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPA
260 270 280 290 300
PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL
360 370 380 390 400
RRDFLRLQLA NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE
410 420 430 440 450
QRRRLEEQQR REKELRKQQE REQRRHYEEQ MRREEERRRA EHEQEYIRRQ
460 470 480 490 500
LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL EEQRQAERLQ RQLKQERDYL
510 520 530 540 550
VSLQHQRQEQ RPLEKKPLYH YKEGMSPSEK PAWAKEVEER SRLNRQSSPA
560 570 580 590 600
MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPQLVAVKS
610 620 630 640 650
QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP
660 670 680 690 700
TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG
710 720 730 740 750
SQPIRASNPD LRRTEPVLES SLQRTSSGSS SSSSTPSSQP SSQGGSQPGS
760 770 780 790 800
QAGSSERSRV RANSKSEGSP VLPHEPSKVK PEESRDITRP SRPADLTALA
810 820 830 840 850
KELRELRIEE TNRPLKKVTD YSSSSEESES SEEEEEDGES ETHDGTVAVS
860 870 880 890 900
DIPRLIPTGA PGNNEQYNMG MVGTHGLETS HADTFGGSIS REGTLMIRET
910 920 930 940 950
AEEKKRSGHS DSNGFAGHIN LPDLVQQSHS PAGTPTEGLG RVSTHSQEMD
960 970 980 990 1000
SGAEYGIGSS TKASFTPFVD PRVYQTSPTD EDEEDDESSA AALFTSELLR
1010 1020 1030 1040 1050
QEQAKLNEAR KISVVNVNPT NIRPHSDTPE IRKYKKRFNS EILCAALWGV
1060 1070 1080 1090 1100
NLLVGTENGL MLLDRSGQGK VYNLINRRRF QQMDVLEGLN VLVTISGKKN
1110 1120 1130 1140 1150
KLRVYYLSWL RNRILHNDPE VEKKQGWITV GDLEGCIHYK VVKYERIKFL
1160 1170 1180 1190 1200
VIALKNAVEI YAWAPKPYHK FMAFKSFADL QHKPLLVDLT VEEGQRLKVI
1210 1220 1230 1240 1250
FGSHTGFHVI DVDSGNSYDI YIPSHIQGNI TPHAIVILPK TDGMEMLVCY
1260 1270 1280 1290 1300
EDEGVYVNTY GRITKDVVLQ WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE
1310 1320 1330 1340 1350
TGHLDGVFMH KRAQRLKFLC ERNDKVFFAS VRSGGSSQVF FMTLNRNSMM

NW
Length:1,352
Mass (Da):154,010
Last modified:March 24, 2009 - v1
Checksum:iDFEAFCC65B74A024
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108428 Genomic DNA. No translation available.
AC114825 Genomic DNA. No translation available.
AC121268 Genomic DNA. No translation available.
AC147186 Genomic DNA. No translation available.
AC160933 Genomic DNA. No translation available.
BC151003 mRNA. Translation: AAI51004.1.
RefSeqiNP_001156479.1. NM_001163007.1.
UniGeneiMm.126193.
Mm.483052.

Genome annotation databases

EnsembliENSMUST00000159680; ENSMUSP00000124876; ENSMUSG00000027692.
GeneIDi665113.
UCSCiuc012coc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108428 Genomic DNA. No translation available.
AC114825 Genomic DNA. No translation available.
AC121268 Genomic DNA. No translation available.
AC147186 Genomic DNA. No translation available.
AC160933 Genomic DNA. No translation available.
BC151003 mRNA. Translation: AAI51004.1.
RefSeqiNP_001156479.1. NM_001163007.1.
UniGeneiMm.126193.
Mm.483052.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159680; ENSMUSP00000124876; ENSMUSG00000027692.
GeneIDi665113.
UCSCiuc012coc.1. mouse.

Organism-specific databases

CTDi23043.
MGIiMGI:1916264. Tnik.

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG036506.

Miscellaneous databases

ChiTaRSiTnik. mouse.
NextBioi426671.
SOURCEiSearch...

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB9EKN8_MOUSE
AccessioniPrimary (citable) accession number: B9EKN8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.