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Protein
Submitted name:

Casitas B-lineage lymphoma b

Gene

Cblb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Casitas B-lineage lymphoma bImported
Submitted name:
E3 ubiquitin-protein ligase CBL-BImported
Gene namesi
Name:CblbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146430 Cblb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000022637

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606313EBI-682463,EBI-1688

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 343Cbl-PTBInterPro annotationAdd BLAST309
Domaini373 – 412RING-typeInterPro annotationAdd BLAST40
Domaini887 – 926UBAInterPro annotationAdd BLAST40

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
HOGENOMiHOG000294176
HOVERGENiHBG005255
KOiK04707
OMAiCCSIIDP
OrthoDBiEOG091G0GPE
TreeFamiTF314210

Family and domain databases

CDDicd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.201 hit
3.30.40.101 hit
3.30.505.101 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR015940 UBA
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 2 hits
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS50030 UBA, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9EKI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW
60 70 80 90 100
KLMDKVVRLC QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ
110 120 130 140 150
LSENEYFKIY IDSLMKKSKR AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF
160 170 180 190 200
SHMLAEIKAI FPNGQFQGDN FRITKADAAE FWRKFFGDKT IVPWKVFRQC
210 220 230 240 250
LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWGSILRNW
260 270 280 290 300
NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV
310 320 330 340 350
TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH
360 370 380 390 400
DHIKVTQEQY ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW
410 420 430 440 450
QESDGQGCPF CRCEIKGTEP IIVDPFDPRD EGSRCCSIID PFSIPMLDLD
460 470 480 490 500
DDDDREESLM MNRLASVRKC TDRQNSPVTS PGSSPLAQRR KPQPDPLQIP
510 520 530 540 550
HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ DKPLPAPPPP
560 570 580 590 600
LRDPPPPPER PPPIPPDNRL SRHFHHGESV PSRDQPMPLE AWCPRDAFGT
610 620 630 640 650
NQVMGCRILG DGSPKPGVTA NSSLNGRHSR MGSEQVLMRK HRRHDLPSEG
660 670 680 690 700
AKVFSNGHLA TEEYDVPPRL SPPPPVTTLL PSIKCTGPLA NCLSEKTRDT
710 720 730 740 750
VEDDDDEYKI PSSHPVSLNS QPSHCHNVKA PVRSCDNGHC ILNGTHGAPS
760 770 780 790 800
EMKKSNIPDL GIYLKGEDAF DALPPSLPPP PPPARHSLIE HSKPPGSSSR
810 820 830 840 850
PSSGQDLFLL PSDPFFDPTS GQVPLPPARR AAGDSGKANR ASQDYDQLPS
860 870 880 890 900
SSDGSQAPAR PPKPRPRRTA PEIHHRKPHG PEAALENVDA KIAKLMGEGY
910 920 930
AFEEVKRALE IAQNNVEVAR SILREFAFPP PVSPRLNL
Length:938
Mass (Da):104,592
Last modified:March 24, 2009 - v1
Checksum:iD27C95AE6ACAF166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117780 Genomic DNA No translation available.
AC154251 Genomic DNA No translation available.
AC154478 Genomic DNA No translation available.
BC150934 mRNA Translation: AAI50935.1
BC150938 mRNA Translation: AAI50939.1
RefSeqiNP_001028410.1, NM_001033238.1
XP_006522014.1, XM_006521951.1
UniGeneiMm.328206

Genome annotation databases

EnsembliENSMUST00000114471; ENSMUSP00000110115; ENSMUSG00000022637
ENSMUST00000227062; ENSMUSP00000154583; ENSMUSG00000022637
GeneIDi208650
KEGGimmu:208650
UCSCiuc007zle.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB9EKI5_MOUSE
AccessioniPrimary (citable) accession number: B9EKI5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported