ID   B9EJX5_MOUSE            Unreviewed;      1198 AA.
AC   B9EJX5;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=Transcription initiation factor TFIID subunit 2 {ECO:0000256|ARBA:ARBA00017363};
DE   AltName: Full=Transcription initiation factor TFIID 150 kDa subunit {ECO:0000256|ARBA:ARBA00033345};
GN   Name=Taf2 {ECO:0000313|EMBL:AAI47639.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000043733.8,
GN   ECO:0000313|MGI:MGI:2443028};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI47639.1};
RN   [1] {ECO:0000313|EMBL:AAI47639.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI47639.1}, and Testicle
RC   {ECO:0000313|EMBL:AAI51080.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000043733.8, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000043733.8,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000043733.8}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000043733.8};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TAF2 family.
CC       {ECO:0000256|ARBA:ARBA00010937}.
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DR   EMBL; BC147638; AAI47639.1; -; mRNA.
DR   EMBL; BC151079; AAI51080.1; -; mRNA.
DR   RefSeq; NP_001074757.1; NM_001081288.1.
DR   ProteomicsDB; 341397; -.
DR   Antibodypedia; 26803; 176 antibodies from 22 providers.
DR   Ensembl; ENSMUST00000041733.9; ENSMUSP00000043733.8; ENSMUSG00000037343.9.
DR   GeneID; 319944; -.
DR   KEGG; mmu:319944; -.
DR   UCSC; uc007vrt.1; mouse.
DR   AGR; MGI:2443028; -.
DR   CTD; 6873; -.
DR   MGI; MGI:2443028; Taf2.
DR   VEuPathDB; HostDB:ENSMUSG00000037343; -.
DR   GeneTree; ENSGT00390000000420; -.
DR   HOGENOM; CLU_002317_0_0_1; -.
DR   OMA; QYMAAQR; -.
DR   OrthoDB; 11119at2759; -.
DR   TreeFam; TF315208; -.
DR   BioGRID-ORCS; 319944; 30 hits in 86 CRISPR screens.
DR   ChiTaRS; Taf2; mouse.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000037343; Expressed in manus and 228 other cell types or tissues.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR   GO; GO:0033276; C:transcription factor TFTC complex; IEA:Ensembl.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:Ensembl.
DR   CDD; cd09839; M1_like_TAF2; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR037813; TAF2.
DR   PANTHER; PTHR15137; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR   PANTHER; PTHR15137:SF9; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:B9EJX5,
KW   ECO:0007829|MaxQB:B9EJX5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1068..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1137..1198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1074..1092
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1142..1171
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1198 AA;  136926 MW;  9FA604069E20829C CRC64;
     MPPTGLESSR MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE LTIFPTVANL
     NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ RNLNYFSNAY AAAVSAVDPD
     AGNGELCIKV PSELWKHVDE LKVLKIHINF SLDQPKGGLH FVVPSVEGSM AERGAHVFSC
     GYQNSTRFWF PCVDSYSELC TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI
     PTAASNISLA IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYIHEVFEF YEEILTCRYP
     YSCFKTVFID EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQAL AQQFFGCFIS
     RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YHHWIKEELD KIVAYELKTG GVLLHPIFGG
     GKEKDNPASH LHFSIKHPHT LSWEYYTMFQ CKAHLVMRLI ENRISMEFML QVFNKLLSLA
     STASSQKFQS HMWSQMLVST YGFLKSISNV SGKDIQPLIK QWVDQSGVVK FYGSFAFNRK
     RNVLELEIKQ DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK
     KKKIPLMNGE EVDMDLSAMD ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ YELRYERDVV
     AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF CLAKIANSMV STWTGPPAMK
     SLFTRMFCCK TCPNIVKTNN FMSFQSYFLQ KTMPVAMALL RDVHNLCPKE VLTFILDLIK
     YNDNRKNKFS DNYYRAEMID ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME
     KLLPSYRHTI TVSCLRAIRV LQKNGHVPSD ASLFKSYAEY GHFVDIRIAA LEAVVDYTKV
     DRSYEELQWL LNMIQTDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV DQLWKLMNSG
     TAHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE KKAVLNPTII PEAGVGNQES
     ASNPGCHAQL AGFQNPFSSS QDEEEVDMDT VHDSQAFISH HLNMLERPST PGLSKYRPSG
     SRSSLMPQHS LGCDITPPTK PQWSMELSRK GAGKEQPLEM GVHSMVAAPL SMFAKEALSS
     RHSEHHHHHH HEHKKKKKKH KHKHKHKHKH DSKDKDREPF AFSSPASGRS VRSPSLSD
//