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Protein
Submitted name:

Protein tyrosine phosphatase, receptor type, D

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, receptor type, DImported
Submitted name:
Receptor-type tyrosine-protein phosphatase deltaImported
Gene namesi
Name:PtprdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97812. Ptprd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei863 – 886HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500875748428 – 1508Sequence analysisAdd BLAST1481

Expressioni

Gene expression databases

BgeeiENSMUSG00000028399.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133468.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 121Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST91
Domaini133 – 231Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST99
Domaini243 – 325Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST83
Domaini332 – 422Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini427 – 523Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini525 – 614Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini616 – 702Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini953 – 1208Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini1128 – 1199TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1240 – 1499Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
Domaini1417 – 1490TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.
KOiK06777.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EJA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTNCRMVP VARPLSLLLT FFLCACAETP PRFTRTPVDQ TGVSGGVASF
60 70 80 90 100
ICQATGDPRP KIVWNKKGKK VSNQRFEVIE FDDGSGSVLR IQPLRTPRDE
110 120 130 140 150
AIYECVASNN VGEISVSTRL TVLREDQIPR GFPTIDMGPQ LKVVERTRTA
160 170 180 190 200
TMLCAASGNP DPEITWFKDF LPVDTSNNNG RIKQLRSESI GGTPIRGALQ
210 220 230 240 250
IEQSEESDQG KYECVATNSA GTRYSAPANL YVRELREVRR VPPRFSIPPT
260 270 280 290 300
NHEIMPGGSV NITCVAVGSP MPYVKWMLGA EDLTPEDDMP IGRNVLELND
310 320 330 340 350
VRQSANYTCV AMSTLGVIEA IAQITVKALP KPPGTPVVTE STATSITLTW
360 370 380 390 400
DSGNPEPVSY YIIQHKPKNS EEPYKEIDGI ATTRYSVAGL SPYSDYEFRV
410 420 430 440 450
VAVNNIGRGP ASEPVLTQTS EQAPSSAPRD VQARMLSSTT ILVQWKEPEE
460 470 480 490 500
PNGQIQGYRV YYTMDPTQHV NNWMKHNVAD SQITTIGNLV PQKTYSVKVL
510 520 530 540 550
AFTSIGDGPL SSDIQVITQT GVPGQPLNFK AEPESETSIL LSWTPPRSDT
560 570 580 590 600
IASYELVYRD GDQGEEQRIT IEPGTSYRLQ GLKPNSLYYF RLSARSPQGL
610 620 630 640 650
GASTAEISAR TMQSMFAKNF HVKAVMKTSV LLSWEIPENY NSAMPFKILY
660 670 680 690 700
DDGKMVEEVD GRATQKLIVN LKPEKSYSFV LTNRGNSAGG LQHRVTAKTA
710 720 730 740 750
PDVLRTKPAF IGKTNLDGMI TVQLPDVPAN ENIKGYYIII VPLKKSRGKF
760 770 780 790 800
IKPWESPDEM ELDELLKEIS RKRRSIRYGR EVELKPYIAA HFDVLPTEFT
810 820 830 840 850
LGDDKHYGGF TNKQLQSGQE YVFFVLAVMD HAESKMYATS PYSDPVVSMD
860 870 880 890 900
LDPQPITDEE EGLIWVVGPV LAVVFIICIV IAILLYKRKR AESESRKSSL
910 920 930 940 950
PNSKEVPSHH PTDPVELRRL NFQTPGMASH PPIPILELAD HIERLKANDN
960 970 980 990 1000
LKFSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVLLSAIEG
1010 1020 1030 1040 1050
IPGSDYVNAN YIDGYRKQNA YIATQGSLPE TFGDFWRMIW EQRSATVVMM
1060 1070 1080 1090 1100
TKLEERSRVK CDQYWPSRGT ETHGLVQVTL LDTVELATYC VRTFALYKNG
1110 1120 1130 1140 1150
SSEKREVRQF QFTAWPDHGV PEHPTPFLAF LRRVKTCNPP DAGPMVVHCS
1160 1170 1180 1190 1200
AGVGRTGCFI VIDAMLERIK HEKTVDIYGH VTLMRAQRNY MVQTEDQYIF
1210 1220 1230 1240 1250
IHDALLEAVT CGNTEVPARN LYAYIQKLTQ IETGENVTGM ELEFKRLASS
1260 1270 1280 1290 1300
KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF
1310 1320 1330 1340 1350
LDGYRQQKAY IATQGPLAET TEDFWRMLWE HNSTIVVMLT KLREMGREKC
1360 1370 1380 1390 1400
HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ
1410 1420 1430 1440 1450
FTDWPEQGVP KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF
1460 1470 1480 1490 1500
ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP AMVQTEDQYQ FCYRAALEYL

GSFDHYAT
Length:1,508
Mass (Da):169,744
Last modified:March 24, 2009 - v1
Checksum:i5D4D09C127769C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844848 Genomic DNA. No translation available.
AL845158 Genomic DNA. No translation available.
AL845333 Genomic DNA. No translation available.
AL845335 Genomic DNA. No translation available.
AL845508 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
AL929553 Genomic DNA. No translation available.
AL954675 Genomic DNA. No translation available.
BX296523 Genomic DNA. No translation available.
BC141409 mRNA. Translation: AAI41410.1.
RefSeqiNP_035341.2. NM_011211.3.
UniGeneiMm.184021.
Mm.403663.
Mm.477158.
Mm.489057.

Genome annotation databases

EnsembliENSMUST00000173376; ENSMUSP00000133468; ENSMUSG00000028399.
GeneIDi19266.
KEGGimmu:19266.
UCSCiuc008tjm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844848 Genomic DNA. No translation available.
AL845158 Genomic DNA. No translation available.
AL845333 Genomic DNA. No translation available.
AL845335 Genomic DNA. No translation available.
AL845508 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
AL929553 Genomic DNA. No translation available.
AL954675 Genomic DNA. No translation available.
BX296523 Genomic DNA. No translation available.
BC141409 mRNA. Translation: AAI41410.1.
RefSeqiNP_035341.2. NM_011211.3.
UniGeneiMm.184021.
Mm.403663.
Mm.477158.
Mm.489057.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173376; ENSMUSP00000133468; ENSMUSG00000028399.
GeneIDi19266.
KEGGimmu:19266.
UCSCiuc008tjm.2. mouse.

Organism-specific databases

CTDi5789.
MGIiMGI:97812. Ptprd.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.
KOiK06777.

Miscellaneous databases

ChiTaRSiPtprd. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028399.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9EJA3_MOUSE
AccessioniPrimary (citable) accession number: B9EJA3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.