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Protein
Submitted name:

Cask protein

Gene

Cask

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cask proteinImported
Gene namesi
Name:CaskImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1309489. Cask.

PTM / Processingi

Proteomic databases

MaxQBiB9EJ23.
PaxDbiB9EJ23.
PeptideAtlasiB9EJ23.
PRIDEiB9EJ23.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031012.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111096.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 276Protein kinaseInterPro annotationAdd BLAST265
Domaini337 – 392L27InterPro annotationAdd BLAST56
Domaini396 – 449L27InterPro annotationAdd BLAST54
Domaini484 – 565PDZ (DHR)InterPro annotationAdd BLAST82
Domaini571 – 641SH3InterPro annotationAdd BLAST71
Domaini693 – 865Guanylate kinase-likeInterPro annotationAdd BLAST173

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
KOG0609. Eukaryota.
COG0194. LUCA.
HOVERGENiHBG001858.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EJ23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
60 70 80 90 100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
110 120 130 140 150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
160 170 180 190 200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
210 220 230 240 250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
260 270 280 290 300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
310 320 330 340 350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE
360 370 380 390 400
IHALTDCSEK DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP QIRNPPSDAV
410 420 430 440 450
QRAKEVLEEI SCYPENNDAK ELKRILTQPH FMALLQTHDV VAHEVYSDEA
460 470 480 490 500
LRVTPPPTSP YLNGDSPESA NGDMDMENVT RVRLVQFQKN TDEPMGITLK
510 520 530 540 550
MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN QTVEQLQKML
560 570 580 590 600
REMRGSITFK IVPSYRTQSS SCEIYVRAQF EYDPAKDDLI PCKEAGIRFR
610 620 630 640 650
VGDIIQIISK DDHNWWQGKL ENSKNGTAGL IPSPELQEWR VACIAMEKTK
660 670 680 690 700
QEQQASCTWF GKKKKQYKDK YLAKHNADLV TYEEVVKLPA FKRKTLVLLG
710 720 730 740 750
AHGVGRRHIK NTLITKHPDR FAYPIPHTTR PPKKDEENGK NYYFVSHDQM
760 770 780 790 800
MQDISNNEYL EYGSHEDAMY GTKLETIRKI HEQGLIAILD VEPQALKVLR
810 820 830 840 850
TAEFAPFVVF IAAPTITPGL NEDESLQRLQ KESDVLQRTY AHYFDLTIIN
860 870 880
NEIDETIRHL EEAVELVCTA PQWVPVSWVY
Length:880
Mass (Da):100,187
Last modified:March 24, 2009 - v1
Checksum:i3F51FB48B8E5A390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141292 mRNA. Translation: AAI41293.1.
RefSeqiNP_001271433.1. NM_001284504.1.
UniGeneiMm.327591.
Mm.474948.

Genome annotation databases

GeneIDi12361.
UCSCiuc012hfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141292 mRNA. Translation: AAI41293.1.
RefSeqiNP_001271433.1. NM_001284504.1.
UniGeneiMm.327591.
Mm.474948.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111096.

Proteomic databases

MaxQBiB9EJ23.
PaxDbiB9EJ23.
PeptideAtlasiB9EJ23.
PRIDEiB9EJ23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12361.
UCSCiuc012hfa.2. mouse.

Organism-specific databases

CTDi8573.
MGIiMGI:1309489. Cask.

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
KOG0609. Eukaryota.
COG0194. LUCA.
HOVERGENiHBG001858.

Miscellaneous databases

ChiTaRSiCask. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031012.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9EJ23_MOUSE
AccessioniPrimary (citable) accession number: B9EJ23
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.