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Protein
Submitted name:

Ataxia telangiectasia mutated homolog (Human)

Gene

Atm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ataxia telangiectasia mutated homolog (Human)Imported
Submitted name:
Atm proteinImported
Gene namesi
Name:AtmImported
ORF Names:mCG_5641Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107202. Atm.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113388.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1966 – 2573608FATInterPro annotationAdd
BLAST
Domaini2719 – 3063345PI3K/PI4KInterPro annotationAdd
BLAST
Domaini3031 – 306333FATCInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1617 – 164428Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation
Contains FAT domain.SAAS annotation
Contains FATC domain.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0892. Eukaryota.
ENOG410XNPY. LUCA.
HOVERGENiHBG004304.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 11 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EHX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLALNDLLI CCRQLEHDRA TERRKEVDKF KRLIQDPETV QHLDRHSDSK
60 70 80 90 100
QGKYLNWDAV FRFLQKYIQK EMESLRTAKS NVSATTQSSR QKKMQEISSL
110 120 130 140 150
VRYFIKCANK RAPRLKCQDL LNYVMDTVKD SSNGLTYGAD CSNILLKDIL
160 170 180 190 200
SVRKYWCEVS QQQWLELFSL YFRLYLKPSQ DINRVLVARI IHAVTRGCCS
210 220 230 240 250
QTDGLPSKFL DLFSKAIQYA RQEKSSPGLS HILAALNIFL KSLAVNFRKR
260 270 280 290 300
VCEAGDEILP TLLYIWTQHR LNDSLKEVII ELIQLQIYIH HPQGARAPEE
310 320 330 340 350
GAYESMKWKS ILYNLYDLLV NEISHIGSRG KYSSGSRNIA VKENLIDLMA
360 370 380 390 400
DICYQLFDAD TRSVEISQSY VTQRESTDYS VPCKRRKIDV GWEVIKDYLQ
410 420 430 440 450
KSQSDFDLVP WLQITTRLIS KYPSSLPNCE LSPLILILYQ LLPQQRRGER
460 470 480 490 500
IPYVLRCLKE VALCQGKKSN LESSQKSDLL KLWIKIWSIT FRGISSGQTQ
510 520 530 540 550
TENFGLLEAI IQGSLVELDR EFWKLFTGSA CKPSSPSVCC LTLALSICVV
560 570 580 590 600
PDAIKMGTEQ SVCEANRSFS VKESIMRWLL FYQLEDDLED STELPPILQS
610 620 630 640 650
NFPHLVVEKI LVSLTMKNSK AAMKFFQSVP ECEQHCEDKE EPSFSEVEEL
660 670 680 690 700
FLQTTFDKMD FLTTVKEYAV EKFQSSVGFS VQQNLKESLD HYLLGLSEQL
710 720 730 740 750
LSNYSSEITS SETLVRCSSL LVGVLGCYCY MGIITEDEAH KSELFQKAKS
760 770 780 790 800
LMQCAGESIS LFKNKTNEES RIGSLRNVMH LCTSCLCIHT KHTPNKIASG
810 820 830 840 850
FFLRLLTSKL MNDIADICKS LASCTKKPLD HGVHPGEDDE DGGGCDSLME
860 870 880 890 900
AEGPSSTGLS TAYPASSVSD ANDYGENQNA VGAMSPLAAD YLSKQDHLLL
910 920 930 940 950
DMLRFLGRSV TASQSHTVSF RGADIRRKLL LLLDSSILDL MKPLHLHMYL
960 970 980 990 1000
VLLKDLPGNE HSLPMEDVVE LLQPLSLVCS LHRRDQDVCK TILSNVLHIV
1010 1020 1030 1040 1050
TNLGQGSVDM ESTRIAQGHF LTVMGAFWHL TKEKKCVFSV RMALVKCLQT
1060 1070 1080 1090 1100
LLEADPYSEW AILNVKGQDF PVNEAFSQFL ADDHHQVRML AAGSVNRLFQ
1110 1120 1130 1140 1150
DMRQGDFSRS LKALPLKFQQ TSFNNAYTTA EAGIRGLLCD SQNPDLLDEI
1160 1170 1180 1190 1200
YNRKSVLLMM IAVVLHCSPV CEKQALFALC KSVKENRLEP HLVKKVLEKV
1210 1220 1230 1240 1250
SESFGCRSLE DFMISHLDYL VLEWLNLQDT EYSLSSFPFM LLNYTSIEDF
1260 1270 1280 1290 1300
YRSCYKILIP HLVIRSHFDE VKSIANQIQK CWKSLLVDCF PKILVHILPY
1310 1320 1330 1340 1350
FAYEGTRDSY VSQKRETATK VYDTLKGEDF LGKQIDQVFI SNLPEIVVEL
1360 1370 1380 1390 1400
LMTLHETADS ADSDASQSAT ALCDFSGDLD PAPNPPYFPS HVIQATFAYI
1410 1420 1430 1440 1450
SNCHKTKFKS ILEILSKIPD SYQKILLAIC EQAAETNNVF KKHRILKIYH
1460 1470 1480 1490 1500
LFVSLLLKDI QSGLGGAWAF VLRDVIYTLI HYINKRSSHF TDVSLRSFSL
1510 1520 1530 1540 1550
CCDLLSRVCH TAVTQCKDAL ESHLHVIVGT LIPLVDYQEV QEQVLDLLKY
1560 1570 1580 1590 1600
LVIDNKDNKN LSVTIKLLDP FPDHVIFKDL RLTQQKIKYS GGPFSLLEEI
1610 1620 1630 1640 1650
NHFLSVSAYN PLPLTRLEGL KDLRRQLEQH KDQMLDLLRA SQDNPQDGIV
1660 1670 1680 1690 1700
VKLVVSLLQL SKMAVNQTGE REVLEAVGRC LGEIGPLDFS TIAVQHNKDV
1710 1720 1730 1740 1750
SYTKAYGLPE DRELQWTLIM LTALNNTLVE DSVKIRSAAA TCLKNILATK
1760 1770 1780 1790 1800
IGHIFWENYK TSADPMLTYL QPFRTSRKKF LEVPRSVKED VLEGLDAVNL
1810 1820 1830 1840 1850
WVPQSESHDI WIKTLTCAFL DSGGINSEIL QLLKPMCEVK TDFCQMLLPY
1860 1870 1880 1890 1900
LIHDVLLQDT HESWRTLLSA HVRGFFTSCF KHSSQASRSA TPANSDSESE
1910 1920 1930 1940 1950
NFLRCCLDKK SQRTMLAVVD YLRRQKRPSS GTAFDDAFWL DLNYLEVAKV
1960 1970 1980 1990 2000
AQSCSAHFTA LLYAEIYSDK KSTDEQEKRS PTFEEGSQGT TISSLSEKSK
2010 2020 2030 2040 2050
EETGISLQDL LLEIYRSIGE PDSLYGCGGG KMLQPLTRIR TYEHEATWEK
2060 2070 2080 2090 2100
ALVTYDLETS ISSSTRQSGI IQALQNLGLS HILSVYLKGL DYERREWCAE
2110 2120 2130 2140 2150
LQELRYQAAW RNMQWGLCAS AGQEVEGTSY HESLYNALQC LRNREFSTFY
2160 2170 2180 2190 2200
ESLRYARVKE VEELSKGSLE SVYSLYPTLS RLQAIGELEN SGELFSRSVT
2210 2220 2230 2240 2250
DRERSEAYWK WQKHSQLLKD SDFSFQEPLM ALRTVILETL VQKEMERSQG
2260 2270 2280 2290 2300
ACSKDILTKH LVEFSVLART FKNTQLPERA IFKIKQYNSA ICGISEWHLE
2310 2320 2330 2340 2350
EAQVFWAKKE QSLALSILKQ MIKKLDSSFK DKENDAGLKV IYAECLRVCG
2360 2370 2380 2390 2400
SWLAETCLEN PAVIMQTYLE KAVKVAGSYD GNSRELRNGQ MKAFLSLARF
2410 2420 2430 2440 2450
SDTQYQRIEN YMKSSEFENK QTLLKRAKEE VGLLREHKIQ TNRYTVKVQR
2460 2470 2480 2490 2500
ELELDECALR ALREDRKRFL CKAVENYINC LLSGEEHDLW VFRLCSLWLE
2510 2520 2530 2540 2550
NSGVSEVNGM MKKDGMKISS YKFLPLMYQL AARMGTKMTG GLGFHEVLNN
2560 2570 2580 2590 2600
LISRISLDHP HHTLFIILAL ANANKDEFLS KPETTRRSRI TKSTSKENSH
2610 2620 2630 2640 2650
LDEDRTEAAT RIIHSIRSKR CKMVKDMEAL CDAYIILANM DASQWRAQRK
2660 2670 2680 2690 2700
GINIPANQPI TKLKNLEDVV VPTMEIKVDP TGEYENLVTI KSFKTEFRLA
2710 2720 2730 2740 2750
GGLNLPKIID CVGSDGKERR QLVKGRDDLR QDAVMQQVFQ MCNTLLQRNT
2760 2770 2780 2790 2800
ETRKRKLTIC TYKVVPLSQR SGVLEWCTGT VPIGEYLVNS EDGAHRRYRP
2810 2820 2830 2840 2850
NDFSANQCQK KMMEVQKKSF EEKYDTFMTI CQNFEPVFRY FCMEKFLDPA
2860 2870 2880 2890 2900
VWFEKRLAYT RSVATSSIVG YILGLGDRHV QNILINEQSA ELVHIDLGVA
2910 2920 2930 2940 2950
FEQGKILPTP ETVPFRLSRD IVDGMGITGV EGVFRRCCEK TMEVMRSSQE
2960 2970 2980 2990 3000
TLLTIVEVLL YDPLFDWTMN PLKALYLQQR PEDESDLHST PNADDQECKQ
3010 3020 3030 3040 3050
SLSDTDQSFN KVAERVLMRL QEKLKGVEEG TVLSVGGQVN LLIQQAMDPK
3060
NLSRLFPGWK AWV
Length:3,063
Mass (Da):349,071
Last modified:March 24, 2009 - v1
Checksum:i51BE4B58F000C816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138525 mRNA. Translation: AAI38526.1.
CH466522 Genomic DNA. Translation: EDL25796.1.
RefSeqiXP_006510019.1. XM_006509956.2.
UniGeneiMm.5088.

Genome annotation databases

GeneIDi11920.
UCSCiuc012gtj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138525 mRNA. Translation: AAI38526.1.
CH466522 Genomic DNA. Translation: EDL25796.1.
RefSeqiXP_006510019.1. XM_006509956.2.
UniGeneiMm.5088.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11920.
UCSCiuc012gtj.1. mouse.

Organism-specific databases

CTDi472.
MGIiMGI:107202. Atm.

Phylogenomic databases

eggNOGiKOG0892. Eukaryota.
ENOG410XNPY. LUCA.
HOVERGENiHBG004304.

Miscellaneous databases

ChiTaRSiAtm. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 11 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiB9EHX4_MOUSE
AccessioniPrimary (citable) accession number: B9EHX4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.