B9EHK8 (B9EHK8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Homeo box A1 EMBL AAI38099.1

Gene names

Name:

Hoxa1 EMBL AAI38099.1 MGI 96170

Organism

Mus musculus (Mouse) EMBL AAI38099.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Sequence similarities	Contains 1 homeobox DNA-binding domain. SAAS SAAS020479

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682 SAAS SAAS020479
Domain	Homeobox SAAS SAAS020479 RuleBase RU000682
Ligand	DNA-binding RuleBase RU000682 SAAS SAAS020479
Gene Ontology (GO)
Biological_process	abducens nerve formation Inferred from electronic annotation. Source: Compara anatomical structure formation involved in morphogenesis Inferred from genetic interaction PubMed 10529420. Source: MGI anterior/posterior pattern specification Inferred from mutant phenotype PubMed 15367676. Source: MGI artery morphogenesis Inferred from electronic annotation. Source: Compara central nervous system neuron differentiation Inferred from mutant phenotype PubMed 9806922. Source: MGI cochlea morphogenesis Inferred from electronic annotation. Source: Compara cognition Inferred from electronic annotation. Source: Compara embryonic neurocranium morphogenesis Inferred from electronic annotation. Source: Compara facial nerve structural organization Inferred from genetic interaction PubMed 9806922. Source: MGI facial nucleus development Inferred from mutant phenotype PubMed 8102800. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 15367676. Source: MGI motor neuron axon guidance Inferred from genetic interaction PubMed 9806922. Source: MGI neuromuscular process Inferred from electronic annotation. Source: Compara optokinetic behavior Inferred from electronic annotation. Source: Compara outer ear morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18787068. Source: MGI regulation of behavior Inferred from electronic annotation. Source: Compara rhombomere 3 development Inferred from mutant phenotype PubMed 9806922. Source: MGI rhombomere 4 development Inferred from mutant phenotype PubMed 8102800PubMed 9806922. Source: MGI rhombomere 5 development Inferred from mutant phenotype PubMed 8102800PubMed 9806922. Source: MGI semicircular canal formation Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B9EHK8 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 5BE0FC3142D28DB2	FASTA	337	36,761
	10 20 30 40 50 60 MDNARMNSFL EYPILGSGDS GTCSARAYPS DHGITTFQSC AVSANSCGGD DRFLVGRGVQ 70 80 90 100 110 120 ISSPHHHHHH HHHHHHPQTA TYQTSGNLGI SYSHSSCGPS YGAQNFSAPY GPYGLNQEAD 130 140 150 160 170 180 VSGGYPPCAP AVYSGNLSTP MVQHHHHHQG YAGGTVGSPQ YIHHSYGQEQ QTLALATYNN 190 200 210 220 230 240 SLSPLHASHQ EACRSPASET SSPAQTFDWM KVKRNPPKTG KVGEYGYVGQ PNAVRTNFTT 250 260 270 280 290 300 KQLTELEKEF HFNKYLTRAR RVEIAASLQL NETQVKIWFQ NRRMKQKKRE KEGLLPISPA 310 320 330 TPPGSDEKTE ESSEKSSPSP SAPSPASSTS DTLTTSH

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI38099.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC138098 mRNA. Translation: AAI38099.1.
IPI	IPI00132373.
UniGene	Mm.197.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000000964. B9EHK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:96170. Hoxa1.
Phylogenomic databases
HOGENOM	HOG000247020.
HOVERGEN	HBG006089.
Gene expression databases
ArrayExpress	B9EHK8.
Bgee	B9EHK8.
Genevestigator	B9EHK8.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35547937.
SOURCE	Search...

Entry information

Entry name

B9EHK8_MOUSE

Accession

Primary (citable) accession number: B9EHK8

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)