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Protein
Submitted name:

Homeo box A1

Gene

Hoxa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. abducens nerve formation Source: MGI
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. anatomical structure morphogenesis Source: MGI
  4. anterior/posterior pattern specification Source: MGI
  5. artery development Source: MGI
  6. artery morphogenesis Source: MGI
  7. cellular response to retinoic acid Source: MGI
  8. central nervous system neuron differentiation Source: MGI
  9. cochlea development Source: MGI
  10. cochlea morphogenesis Source: MGI
  11. cognition Source: MGI
  12. embryonic neurocranium morphogenesis Source: MGI
  13. facial nerve structural organization Source: MGI
  14. facial nucleus development Source: MGI
  15. hindbrain development Source: MGI
  16. inner ear development Source: MGI
  17. inner ear morphogenesis Source: MGI
  18. motor neuron axon guidance Source: MGI
  19. nervous system development Source: MGI
  20. neuromuscular process Source: MGI
  21. optokinetic behavior Source: MGI
  22. outer ear morphogenesis Source: MGI
  23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  24. regulation of behavior Source: MGI
  25. regulation of transcription from RNA polymerase II promoter Source: MGI
  26. rhombomere 3 development Source: MGI
  27. rhombomere 4 development Source: MGI
  28. rhombomere 5 development Source: MGI
  29. semicircular canal formation Source: MGI
  30. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeo box A1Imported
Submitted name:
Homeobox A1Imported
Submitted name:
Homeobox protein Hox-A1Imported
Gene namesi
Name:Hoxa1Imported
ORF Names:mCG_121168Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96170. Hoxa1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiB9EHK7.

Expressioni

Gene expression databases

BgeeiB9EHK7.
ExpressionAtlasiB9EHK7. baseline and differential.
GenevestigatoriB9EHK7.

Structurei

3D structure databases

ProteinModelPortaliB9EHK7.
SMRiB9EHK7. Positions 203-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006089.
KOiK09301.
OMAiCAVSANS.
OrthoDBiEOG7PK91P.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EHK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNARMNSFL EYPILGSGDS GTCSARAYPS DHGITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLVGRGVQ ISSPHHHHHH HHHHHPQTAT YQTSGNLGIS YSHSSCGPSY
110 120 130 140 150
GAQNFSAPYG PYGLNQEADV SGGYPPCAPA VYSGNLSTPM VQHHHHHQGY
160 170 180 190 200
AGGTVGSPQY IHHSYGQEQQ TLALATYNNS LSPLHASHQE ACRSPASETS
210 220 230 240 250
SPAQTFDWMK VKRNPPKTGK VGEYGYVGQP NAVRTNFTTK QLTELEKEFH
260 270 280 290 300
FNKYLTRARR VEIAASLQLN ETQVKIWFQN RRMKQKKREK EGLLPISPAT
310 320 330
PPGSDEKTEE SSEKSSPSPS APSPASSTSD TLTTSH
Length:336
Mass (Da):36,624
Last modified:March 23, 2009 - v1
Checksum:i52B5E6F7412A9EB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091106 Genomic DNA. No translation available.
BC138097 mRNA. Translation: AAI38098.1.
CH466597 Genomic DNA. Translation: EDK98647.1.
RefSeqiNP_034579.3. NM_010449.4.
XP_006505670.1. XM_006505607.1.
UniGeneiMm.197.

Genome annotation databases

EnsembliENSMUST00000000964; ENSMUSP00000000964; ENSMUSG00000029844.
GeneIDi15394.
KEGGimmu:15394.
UCSCiuc009bxy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091106 Genomic DNA. No translation available.
BC138097 mRNA. Translation: AAI38098.1.
CH466597 Genomic DNA. Translation: EDK98647.1.
RefSeqiNP_034579.3. NM_010449.4.
XP_006505670.1. XM_006505607.1.
UniGeneiMm.197.

3D structure databases

ProteinModelPortaliB9EHK7.
SMRiB9EHK7. Positions 203-291.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB9EHK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000964; ENSMUSP00000000964; ENSMUSG00000029844.
GeneIDi15394.
KEGGimmu:15394.
UCSCiuc009bxy.1. mouse.

Organism-specific databases

CTDi3198.
MGIiMGI:96170. Hoxa1.

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG006089.
KOiK09301.
OMAiCAVSANS.
OrthoDBiEOG7PK91P.
TreeFamiTF317730.

Miscellaneous databases

NextBioi288072.
SOURCEiSearch...

Gene expression databases

BgeeiB9EHK7.
ExpressionAtlasiB9EHK7. baseline and differential.
GenevestigatoriB9EHK7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TesticleImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB9EHK7_MOUSE
AccessioniPrimary (citable) accession number: B9EHK7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2009
Last sequence update: March 23, 2009
Last modified: March 31, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.