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B9EHK7 (B9EHK7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Homeobox A1 EMBL EDK98647.1

Homeobox protein Hox-A1 Ensembl ENSMUSP00000000964
Gene names
Name:Hoxa1 EMBL AAI38098.1 Ensembl ENSMUSP00000000964 MGI 96170
ORF Names:mCG_121168 EMBL EDK98647.1
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAI38098.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity RuleBase RU000682.

Sequence similarities

Contains homeobox DNA-binding domain. SAAS SAAS020479

Ontologies

Keywords
   Cellular componentNucleus SAAS SAAS020479 RuleBase RU000682
   DomainHomeobox SAAS SAAS020479 RuleBase RU000682 EMBL EDK98647.1
   LigandDNA-binding SAAS SAAS020479 RuleBase RU000682
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processabducens nerve formation

Inferred from electronic annotation. Source: Ensembl

anatomical structure formation involved in morphogenesis

Inferred from genetic interaction PubMed 10529420. Source: MGI

anatomical structure morphogenesis

Inferred from genetic interaction PubMed 10529420. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 15367676. Source: MGI

artery morphogenesis

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron differentiation

Inferred from mutant phenotype PubMed 9806922. Source: MGI

cochlea morphogenesis

Inferred from electronic annotation. Source: Ensembl

cognition

Inferred from electronic annotation. Source: Ensembl

embryonic neurocranium morphogenesis

Inferred from electronic annotation. Source: Ensembl

facial nerve structural organization

Inferred from genetic interaction PubMed 9806922. Source: MGI

facial nucleus development

Inferred from mutant phenotype PubMed 8102800. Source: MGI

hindbrain development

Inferred from mutant phenotype PubMed 15367676. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15367676. Source: MGI

motor neuron axon guidance

Inferred from genetic interaction PubMed 9806922. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 15367676. Source: MGI

neuromuscular process

Inferred from electronic annotation. Source: Ensembl

optokinetic behavior

Inferred from electronic annotation. Source: Ensembl

outer ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18787068. Source: MGI

regulation of behavior

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15465489. Source: MGI

rhombomere 3 development

Inferred from mutant phenotype PubMed 9806922. Source: MGI

rhombomere 4 development

Inferred from mutant phenotype PubMed 8102800PubMed 9806922. Source: MGI

rhombomere 5 development

Inferred from mutant phenotype PubMed 8102800PubMed 9806922. Source: MGI

semicircular canal formation

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B9EHK7 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 52B5E6F7412A9EB5

FASTA33636,624
        10         20         30         40         50         60 
MDNARMNSFL EYPILGSGDS GTCSARAYPS DHGITTFQSC AVSANSCGGD DRFLVGRGVQ 

        70         80         90        100        110        120 
ISSPHHHHHH HHHHHPQTAT YQTSGNLGIS YSHSSCGPSY GAQNFSAPYG PYGLNQEADV 

       130        140        150        160        170        180 
SGGYPPCAPA VYSGNLSTPM VQHHHHHQGY AGGTVGSPQY IHHSYGQEQQ TLALATYNNS 

       190        200        210        220        230        240 
LSPLHASHQE ACRSPASETS SPAQTFDWMK VKRNPPKTGK VGEYGYVGQP NAVRTNFTTK 

       250        260        270        280        290        300 
QLTELEKEFH FNKYLTRARR VEIAASLQLN ETQVKIWFQN RRMKQKKREK EGLLPISPAT 

       310        320        330 
PPGSDEKTEE SSEKSSPSPS APSPASSTSD TLTTSH 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98647.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testicle EMBL AAI38098.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98647.1.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000000964.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000000964.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC091106 Genomic DNA. No translation available.
BC138097 mRNA. Translation: AAI38098.1.
CH466597 Genomic DNA. Translation: EDK98647.1.
RefSeqNP_034579.3. NM_010449.4.
XP_006505670.1. XM_006505607.1.
UniGeneMm.197.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000964; ENSMUSP00000000964; ENSMUSG00000029844.
GeneID15394.
KEGGmmu:15394.
UCSCuc009bxy.1. mouse.

Organism-specific databases

CTD3198.
MGIMGI:96170. Hoxa1.

Phylogenomic databases

GeneTreeENSGT00750000117389.
HOVERGENHBG006089.
KOK09301.
OMACAVSANS.
OrthoDBEOG7PK91P.
TreeFamTF317730.

Gene expression databases

GenevestigatorB9EHK7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288072.
SOURCESearch...

Entry information

Entry nameB9EHK7_MOUSE
AccessionPrimary (citable) accession number: B9EHK7
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)