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B9EHJ3

- B9EHJ3_MOUSE

UniProt

B9EHJ3 - B9EHJ3_MOUSE

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Protein
Submitted name:

Tight junction protein ZO-1

Gene

Tjp1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein domain specific binding Source: MGI

GO - Biological processi

  1. blastocyst formation Source: MGI
  2. sensory perception of sound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tight junction protein ZO-1Imported
Submitted name:
Tjp1 proteinImported
Gene namesi
Name:Tjp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98759. Tjp1.

Subcellular locationi

GO - Cellular componenti

  1. adherens junction Source: MGI
  2. apical junction complex Source: MGI
  3. apical part of cell Source: MGI
  4. apical plasma membrane Source: MGI
  5. apicolateral plasma membrane Source: MGI
  6. basolateral plasma membrane Source: MGI
  7. cell-cell adherens junction Source: MGI
  8. cell-cell junction Source: MGI
  9. cell junction Source: MGI
  10. cell surface Source: MGI
  11. cytoplasm Source: MGI
  12. intercalated disc Source: MGI
  13. intercellular canaliculus Source: MGI
  14. membrane Source: MGI
  15. nucleus Source: MGI
  16. plasma membrane Source: MGI
  17. tight junction Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB9EHJ3.

Family & Domainsi

Sequence similaritiesi

Contains 3 PDZ (DHR) domains.UniRule annotation
Contains SH3 domain.SAAS annotation
Contains SHdomain.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00640000091263.
HOVERGENiHBG007849.
KOiK05701.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005418. ZonOcculS1.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01598. ZONOCCLUDNS1.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EHJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARAAAAKS TAMEETAIWE QHTVTLHRAP GFGFGIAISG GRDNPHFQSG
60 70 80 90 100
ETSIVISDVL KGGPAEGQLQ ENDRVAMVNG VSMDNVEHAF AVQQLRKSGK
110 120 130 140 150
NAKITIRRKK KVQIPVSHPD PEPVSDNEDD SYDEEVHDPR AGRGALANRR
160 170 180 190 200
SEKSWARDRS ASRERSLSPR SDRRSVASSQ PAKPTKVTLV KSRKNEEYGL
210 220 230 240 250
RLASHIFVKE ISQDSLAARD GNIQEGDVVL KINGTVTENM SLTDAKTLIE
260 270 280 290 300
RSKGKLKMVV QRDERATLLN VPDLSDSIHS ANASERDDIS EIQSLASDHS
310 320 330 340 350
GRSHDRPPRR SQSRSPDQRS EPSDHSTQSP QQPSNGSLRS REEERMSKPG
360 370 380 390 400
AISTPVKHVD DHPPKAVEEV TVEKNEKQTP TLPEPKPVYA QVGQPDVDLP
410 420 430 440 450
VSPSDGALPN SAHEDGILRP SMKLVKFRKG DSVGLRLAGG NDVGIFVAGV
460 470 480 490 500
LEDSPAAKEG LEEGDQILRV NNVDFTNIIR EEAVLFLLDL PKGEEVTILA
510 520 530 540 550
QKKKDVYRRI VESDVGDSFY IRTHFEYEKE SPYGLSFNKG EVFRVVDTLY
560 570 580 590 600
NGKLGSWLAI RIGKNHKEVE RGIIPNKNRA EQLASVQYTL PKTAGGDRAD
610 620 630 640 650
FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE AGFLRPVTIF
660 670 680 690 700
GPIADVAREK LAREEPDIYQ IAKSEPRDAG TDHRSSGIIR LHTIKQIIDQ
710 720 730 740 750
DKHALLDVTP NAVDRLNYAQ WYPIVVFLNP DSKQGVKTMR MRLCPESRKS
760 770 780 790 800
ARKLYERSHK LRKNNHHLFT TTINLNSMND GWYGALKEAI QQQQNQLVWV
810 820 830 840 850
SEGKADGATS DDLDLHDDRL SYLSAPGSEY SMYSTDSRHT SDYEDTDTEG
860 870 880 890 900
GAYTDQELDE TLNDEVGTPP ESAITRSSEP VREDSSGMHH ENQTYPPYSP
910 920 930 940 950
QAQPQAIHRI DSPGLKPASQ QVYRKEPYSE EMMRQNHILK QPALGHPGQR
960 970 980 990 1000
PDKEPNLAYE PQLPYIEKQA SRDLEQPSYR YEVSSYTDQF SRNYDHRLRF
1010 1020 1030 1040 1050
EDRIPTYEDQ WSYYDDKQPY QPRPFENQHP RDLDSRQHPE EASERGYFQR
1060 1070 1080 1090 1100
FEEPAPLSYD SRTRYEQLPR TSTLRHEEQP APAYEVHNRY RPEAQPYSST
1110 1120 1130 1140 1150
GPKSSEPKQY FDQYPRSYEQ VPPPGFTSKT GHYEPLHGAA VVPPLIPSSQ
1160 1170 1180 1190 1200
QKPEVLPSAT KPQPPPPTLT EEEEDPAMKP QSVLTRVKMF ENKRSASLEN
1210 1220 1230 1240 1250
KKDVNDTASF KPPEVASKPP GASLAGPKPV PQSQFSEHDK TLYRLPEPQK
1260 1270 1280 1290 1300
PQVKPPEDIV RSNHYDPEED EEYYRKQLSY FDRRSFESKP SAHLPAGHHS
1310 1320 1330 1340 1350
EPAKPVHSQS QPNFSSYSSK GKPETDAVDR SFSEKRYDPA QATPPPPPLP
1360 1370 1380 1390 1400
SQYSQPAPPL SSSSLHIHSK GAQGEGNSVS LDFQNSYMSK PDPPPSQSKP
1410 1420 1430 1440 1450
ATFRPPTRED PPQTFYPQKS FPDKAPVNGA EQTQKTITPV YNRFTPKPYT
1460 1470 1480 1490 1500
SSARPFERKF ESPKFNHNLL PSETVHKPEL SSKTPTSPKT LMKAHSSTQP
1510 1520 1530 1540 1550
PEFDSGVETF SVHTDKPKYQ MNNISTMPKA VPVSPSAVEE DEDEDGHTVV
1560 1570 1580 1590 1600
ATARGIFNSN GGVLSSIETG VSIIIPQGAI PEGIEQEIYF KVCRDNSILP
1610 1620 1630 1640 1650
PLDKEKGETL LSPLVMCGPH GLKFLKPVEL RLPHCASMTP DGWSFALKSS
1660 1670 1680
DSSSGDPKTW QNKCLPGDPN YLVGANCVSV LIDHF
Length:1,685
Mass (Da):188,852
Last modified:March 24, 2009 - v1
Checksum:i1D4F51FDA6ACFA20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122222 Genomic DNA. No translation available.
AC131741 Genomic DNA. No translation available.
BC138028 mRNA. Translation: AAI38029.1.
RefSeqiNP_001157046.1. NM_001163574.1.
UniGeneiMm.4342.

Genome annotation databases

EnsembliENSMUST00000032729; ENSMUSP00000032729; ENSMUSG00000030516.
GeneIDi21872.
KEGGimmu:21872.
UCSCiuc009hgo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122222 Genomic DNA. No translation available.
AC131741 Genomic DNA. No translation available.
BC138028 mRNA. Translation: AAI38029.1 .
RefSeqi NP_001157046.1. NM_001163574.1.
UniGenei Mm.4342.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032729 ; ENSMUSP00000032729 ; ENSMUSG00000030516 .
GeneIDi 21872.
KEGGi mmu:21872.
UCSCi uc009hgo.2. mouse.

Organism-specific databases

CTDi 7082.
MGIi MGI:98759. Tjp1.

Phylogenomic databases

GeneTreei ENSGT00640000091263.
HOVERGENi HBG007849.
KOi K05701.

Miscellaneous databases

NextBioi 301376.
SOURCEi Search...

Gene expression databases

Genevestigatori B9EHJ3.

Family and domain databases

Gene3Di 2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005418. ZonOcculS1.
IPR000906. ZU5_dom.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view ]
PRINTSi PR01597. ZONOCCLUDNS.
PR01598. ZONOCCLUDNS1.
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  8. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB9EHJ3_MOUSE
AccessioniPrimary (citable) accession number: B9EHJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3