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B9EHJ3 (B9EHJ3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Tjp1 protein EMBL AAI38029.1
Gene names
Name:Tjp1 Ensembl ENSMUSP00000032729 EMBL AAI38029.1 MGI 98759
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAI38029.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1685 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 PDZ (DHR) domains. RuleBase RU003354

Contains SH3 domain. SAAS SAAS008145

Contains SHdomain. SAAS SAAS008145

Ontologies

Keywords
   DomainSH3 domain SAAS SAAS008145
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblastocyst formation

Inferred from mutant phenotype PubMed 18423437. Source: MGI

   Cellular_componentadherens junction

Inferred from direct assay PubMed 12203721. Source: MGI

apical junction complex

Inferred from sequence orthology PubMed 16427635. Source: MGI

apical part of cell

Inferred from direct assay PubMed 23434913PubMed 23610556. Source: MGI

apical plasma membrane

Inferred from direct assay PubMed 21947081. Source: MGI

apicolateral plasma membrane

Inferred from direct assay PubMed 16520537. Source: MGI

basolateral plasma membrane

Inferred from sequence orthology PubMed 16427635. Source: MGI

cell junction

Inferred from direct assay PubMed 16427635PubMed 21411630PubMed 21884682. Source: MGI

cell surface

Inferred from sequence orthology PubMed 12507281. Source: MGI

cell-cell adherens junction

Inferred from direct assay PubMed 11731229PubMed 15728677PubMed 17666436. Source: MGI

cell-cell junction

Inferred from direct assay PubMed 18423437PubMed 20089884PubMed 20473291. Source: MGI

cytoplasm

Inferred from direct assay PubMed 16427635. Source: MGI

intercalated disc

Inferred from direct assay PubMed 18603586. Source: MGI

intercellular canaliculus

Inferred from direct assay PubMed 12068294. Source: MGI

membrane

Inferred from direct assay PubMed 15788452. Source: MGI

nucleus

Inferred from direct assay PubMed 14685273PubMed 16427635. Source: MGI

plasma membrane

Inferred from direct assay PubMed 12060405PubMed 12507281PubMed 15084279PubMed 15775979PubMed 17122142. Source: MGI

tight junction

Inferred from direct assay PubMed 10395790PubMed 11025210PubMed 11689568PubMed 11706048PubMed 12673830PubMed 12832289PubMed 14622136PubMed 14685273PubMed 15775979PubMed 15950600PubMed 16105026PubMed 16199027PubMed 16364283PubMed 16510873PubMed 16520537PubMed 17000770PubMed 17130295PubMed 17138661PubMed 17397395PubMed 17666436PubMed 18308723PubMed 19590046PubMed 20080746PubMed 20551175PubMed 21285373PubMed 22946046. Source: MGI

   Molecular_functionprotein domain specific binding

Inferred from physical interaction PubMed 17666436. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B9EHJ3 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 1D4F51FDA6ACFA20

FASTA1,685188,852
        10         20         30         40         50         60 
MSARAAAAKS TAMEETAIWE QHTVTLHRAP GFGFGIAISG GRDNPHFQSG ETSIVISDVL 

        70         80         90        100        110        120 
KGGPAEGQLQ ENDRVAMVNG VSMDNVEHAF AVQQLRKSGK NAKITIRRKK KVQIPVSHPD 

       130        140        150        160        170        180 
PEPVSDNEDD SYDEEVHDPR AGRGALANRR SEKSWARDRS ASRERSLSPR SDRRSVASSQ 

       190        200        210        220        230        240 
PAKPTKVTLV KSRKNEEYGL RLASHIFVKE ISQDSLAARD GNIQEGDVVL KINGTVTENM 

       250        260        270        280        290        300 
SLTDAKTLIE RSKGKLKMVV QRDERATLLN VPDLSDSIHS ANASERDDIS EIQSLASDHS 

       310        320        330        340        350        360 
GRSHDRPPRR SQSRSPDQRS EPSDHSTQSP QQPSNGSLRS REEERMSKPG AISTPVKHVD 

       370        380        390        400        410        420 
DHPPKAVEEV TVEKNEKQTP TLPEPKPVYA QVGQPDVDLP VSPSDGALPN SAHEDGILRP 

       430        440        450        460        470        480 
SMKLVKFRKG DSVGLRLAGG NDVGIFVAGV LEDSPAAKEG LEEGDQILRV NNVDFTNIIR 

       490        500        510        520        530        540 
EEAVLFLLDL PKGEEVTILA QKKKDVYRRI VESDVGDSFY IRTHFEYEKE SPYGLSFNKG 

       550        560        570        580        590        600 
EVFRVVDTLY NGKLGSWLAI RIGKNHKEVE RGIIPNKNRA EQLASVQYTL PKTAGGDRAD 

       610        620        630        640        650        660 
FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE AGFLRPVTIF GPIADVAREK 

       670        680        690        700        710        720 
LAREEPDIYQ IAKSEPRDAG TDHRSSGIIR LHTIKQIIDQ DKHALLDVTP NAVDRLNYAQ 

       730        740        750        760        770        780 
WYPIVVFLNP DSKQGVKTMR MRLCPESRKS ARKLYERSHK LRKNNHHLFT TTINLNSMND 

       790        800        810        820        830        840 
GWYGALKEAI QQQQNQLVWV SEGKADGATS DDLDLHDDRL SYLSAPGSEY SMYSTDSRHT 

       850        860        870        880        890        900 
SDYEDTDTEG GAYTDQELDE TLNDEVGTPP ESAITRSSEP VREDSSGMHH ENQTYPPYSP 

       910        920        930        940        950        960 
QAQPQAIHRI DSPGLKPASQ QVYRKEPYSE EMMRQNHILK QPALGHPGQR PDKEPNLAYE 

       970        980        990       1000       1010       1020 
PQLPYIEKQA SRDLEQPSYR YEVSSYTDQF SRNYDHRLRF EDRIPTYEDQ WSYYDDKQPY 

      1030       1040       1050       1060       1070       1080 
QPRPFENQHP RDLDSRQHPE EASERGYFQR FEEPAPLSYD SRTRYEQLPR TSTLRHEEQP 

      1090       1100       1110       1120       1130       1140 
APAYEVHNRY RPEAQPYSST GPKSSEPKQY FDQYPRSYEQ VPPPGFTSKT GHYEPLHGAA 

      1150       1160       1170       1180       1190       1200 
VVPPLIPSSQ QKPEVLPSAT KPQPPPPTLT EEEEDPAMKP QSVLTRVKMF ENKRSASLEN 

      1210       1220       1230       1240       1250       1260 
KKDVNDTASF KPPEVASKPP GASLAGPKPV PQSQFSEHDK TLYRLPEPQK PQVKPPEDIV 

      1270       1280       1290       1300       1310       1320 
RSNHYDPEED EEYYRKQLSY FDRRSFESKP SAHLPAGHHS EPAKPVHSQS QPNFSSYSSK 

      1330       1340       1350       1360       1370       1380 
GKPETDAVDR SFSEKRYDPA QATPPPPPLP SQYSQPAPPL SSSSLHIHSK GAQGEGNSVS 

      1390       1400       1410       1420       1430       1440 
LDFQNSYMSK PDPPPSQSKP ATFRPPTRED PPQTFYPQKS FPDKAPVNGA EQTQKTITPV 

      1450       1460       1470       1480       1490       1500 
YNRFTPKPYT SSARPFERKF ESPKFNHNLL PSETVHKPEL SSKTPTSPKT LMKAHSSTQP 

      1510       1520       1530       1540       1550       1560 
PEFDSGVETF SVHTDKPKYQ MNNISTMPKA VPVSPSAVEE DEDEDGHTVV ATARGIFNSN 

      1570       1580       1590       1600       1610       1620 
GGVLSSIETG VSIIIPQGAI PEGIEQEIYF KVCRDNSILP PLDKEKGETL LSPLVMCGPH 

      1630       1640       1650       1660       1670       1680 
GLKFLKPVEL RLPHCASMTP DGWSFALKSS DSSSGDPKTW QNKCLPGDPN YLVGANCVSV 


LIDHF 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI38029.1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000032729.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000032729.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC122222 Genomic DNA. No translation available.
AC131741 Genomic DNA. No translation available.
BC138028 mRNA. Translation: AAI38029.1.
RefSeqNP_001157046.1. NM_001163574.1.
UniGeneMm.4342.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032729; ENSMUSP00000032729; ENSMUSG00000030516.
GeneID21872.
KEGGmmu:21872.
UCSCuc009hgo.2. mouse.

Organism-specific databases

CTD7082.
MGIMGI:98759. Tjp1.

Phylogenomic databases

GeneTreeENSGT00640000091263.
HOVERGENHBG007849.
KOK05701.

Gene expression databases

GenevestigatorB9EHJ3.

Family and domain databases

Gene3D2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005418. ZonOcculS1.
IPR000906. ZU5.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSPR01597. ZONOCCLUDNS.
PR01598. ZONOCCLUDNS1.
SMARTSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301376.
SOURCESearch...

Entry information

Entry nameB9EHJ3_MOUSE
AccessionPrimary (citable) accession number: B9EHJ3
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)