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Protein
Submitted name:

LTBP3 protein

Gene

LTBP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
LTBP3 proteinImported
Submitted name:
Latent transforming growth factor beta binding protein 3, isoform CRA_cImported
Gene namesi
Name:LTBP3Imported
ORF Names:hCG_1812642Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30479.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000168056.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301873.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 24EGF-likeInterPro annotationAdd BLAST24
Domaini160 – 203TB (TGF-beta binding)InterPro annotationAdd BLAST44
Domaini238 – 278EGF-likeInterPro annotationAdd BLAST41
Domaini286 – 338TB (TGF-beta binding)InterPro annotationAdd BLAST53
Domaini457 – 498EGF-likeInterPro annotationAdd BLAST42
Domaini499 – 536EGF-likeInterPro annotationAdd BLAST38
Domaini543 – 585EGF-likeInterPro annotationAdd BLAST43
Domaini627 – 667EGF-likeInterPro annotationAdd BLAST41
Domaini668 – 708EGF-likeInterPro annotationAdd BLAST41
Domaini709 – 748EGF-likeInterPro annotationAdd BLAST40
Domaini749 – 791EGF-likeInterPro annotationAdd BLAST43
Domaini800 – 854TB (TGF-beta binding)InterPro annotationAdd BLAST55
Domaini876 – 918EGF-likeInterPro annotationAdd BLAST43
Domaini919 – 959EGF-likeInterPro annotationAdd BLAST41
Domaini972 – 1022TB (TGF-beta binding)InterPro annotationAdd BLAST51
Domaini1090 – 1130EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IR6V. Eukaryota.
ENOG4110G15. LUCA.
HOGENOMiHOG000293153.
HOVERGENiHBG052370.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 8 hits.
PF12661. hEGF. 1 hit.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00179. EGF_CA. 13 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 11 hits.
PS51364. TB. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9EG76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGQCSSRN QCLCPPDFTG RFCQVPAGGA GGGTGGSGPG LSRTGALSTG
60 70 80 90 100
ALPPLAPEGD SVASKHAIYA VQVIADPPGP GEGPPAQHAA FLVPLGPGQI
110 120 130 140 150
SAEVQAPPPV VNVRVHHPPE ASVQVHRIES SNAESAAPSQ HLLPHPKPSH
160 170 180 190 200
PRPPTQKPLG RCFQDTLPKQ PCGSNPLPGL TKQEDCCGSI GTAWGQSKCH
210 220 230 240 250
KCPQLQYTGV QKPGPVRGEV GADCPQGYKR LNSTHCQDIN ECAMPGVCRH
260 270 280 290 300
GDCLNNPGSY RCVCPPGHSL GPSRTQCIAD KPEEKSLCFR LVSPEHQCQH
310 320 330 340 350
PLTTRLTRQL CCCSVGKAWG ARCQRCPTDG TAAFKEICPA GKGYHILTSH
360 370 380 390 400
QTLTIQGESD FSLFLHPDGP PKPQQLPESP SQAPPPEDTE EERGVTTDSP
410 420 430 440 450
VSEERSVQQS HPTATTTPAR PYPELISRPS PPTMRWFLPD LPPSRSAVEI
460 470 480 490 500
APTQVTETDE CRLNQNICGH GECVPGPPDY SCHCNPGYRS HPQHRYCVDV
510 520 530 540 550
NECEAEPCGP GRGICMNTGG SYNCHCNRGY RLHVGAGGRS CVDLNECAKP
560 570 580 590 600
HLCGDGGFCI NFPGHYKCNC YPGYRLKASR PPVCEDIDEC RDPSSCPDGK
610 620 630 640 650
CENKPGSFKC IACQPGYRSQ GGGACRDVNE CAEGSPCSPG WCENLPGSFR
660 670 680 690 700
CTCAQGYAPA PDGRSCLDVD ECEAGDVCDN GICSNTPGSF QCQCLSGYHL
710 720 730 740 750
SRDRSHCEDI DECDFPAACI GGDCINTNGS YRCLCPQGHR LVGGRKCQDI
760 770 780 790 800
DECSQDPSLC LPHGACKNLQ GSYVCVCDEG FTPTQDQHGC EEVEQPHHKK
810 820 830 840 850
ECYLNFDDTV FCDSVLATNV TQQECCCSLG AGWGDHCEIY PCPVYSSAEF
860 870 880 890 900
HSLCPDGKGY TQDNNIVNYG IPAHRDIDEC MLFGSEICKE GKCVNTQPGY
910 920 930 940 950
ECYCKQGFYY DGNLLECVDV DECLDESNCR NGVCENTRGG YRCACTPPAE
960 970 980 990 1000
YSPAQRQCLS PEEMERAPER RDVCWSQRGE DGMCAGPLAG PALTFDDCCC
1010 1020 1030 1040 1050
RQGRGWGAQC RPCPPRGAGS HCPTSQSESN SFWDTSPLLL GKPPRDEDSS
1060 1070 1080 1090 1100
EEDSDECRCV SGRCVPRPGG AVCECPGGFQ LDASRARCVD IDECRELNQR
1110 1120 1130
GLLCKSERCV NTSGSFRCVC KAGFARSRPH GACVPQRRR
Length:1,139
Mass (Da):122,596
Last modified:March 24, 2009 - v1
Checksum:i50EEDCB507224080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136277 mRNA. Translation: AAI36278.1.
CH471076 Genomic DNA. Translation: EAW74403.1.
RefSeqiNP_001157738.1. NM_001164266.1.
UniGeneiHs.289019.

Genome annotation databases

GeneIDi4054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136277 mRNA. Translation: AAI36278.1.
CH471076 Genomic DNA. Translation: EAW74403.1.
RefSeqiNP_001157738.1. NM_001164266.1.
UniGeneiHs.289019.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4054.

Organism-specific databases

CTDi4054.
PharmGKBiPA30479.

Phylogenomic databases

eggNOGiENOG410IR6V. Eukaryota.
ENOG4110G15. LUCA.
HOGENOMiHOG000293153.
HOVERGENiHBG052370.

Miscellaneous databases

ChiTaRSiLTBP3. human.
GenomeRNAii4054.

Gene expression databases

BgeeiENSG00000168056.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 8 hits.
PF12661. hEGF. 1 hit.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00179. EGF_CA. 13 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 11 hits.
PS51364. TB. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9EG76_HUMAN
AccessioniPrimary (citable) accession number: B9EG76
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.