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B9EC10 (B9EC10_MACCJ) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:odhA HAMAP-Rule MF_01169
Ordered Locus Names:MCCL_1064 EMBL BAH17771.1
OrganismMacrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP] EMBL BAH17771.1
Taxonomic identifier458233 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesMacrococcus

Protein attributes

Sequence length925 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS023784

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. SAAS SAAS023784 HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
B9EC10 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: CF4BA9E54754A667

FASTA925104,156
        10         20         30         40         50         60 
MTKGKNLEEA PPRFGTNLGI LLEMFDQYQN DPSSVSDELQ ELFSNIQRGS TGHSGMGSTD 

        70         80         90        100        110        120 
ADIVKRLMRL IDNIRQYGHL KADIYPLYKP KRDQHIKLSI EDFGLSEEVL KQLPASLVSE 

       130        140        150        160        170        180 
HYGERLNNAF EAITEMQQTY QGPIAYEVSH INNSEEREWL KTTIESKVKR DFSKEEKVEL 

       190        200        210        220        230        240 
LKSVARVEGF EKYIHKNFVG AKRFSIEGVD ALVPMLENVI KFAGENNIQD IEIGMAHRGR 

       250        260        270        280        290        300 
LNVLTHILEK PYEMMLSEFM HTDPMKFLPE DGSLVVKKGW TGDVKYHLGG IKTTTRFGKT 

       310        320        330        340        350        360 
QTISLANNPS HLEIVAPVVL GKTRAVQEVT DGVNEPKQDF NKALAVLIHG DAAFPGQGIN 

       370        380        390        400        410        420 
FESMNLSNLK GYSVGGSLHI ITNNRVGFTT ESYDSRSTTY ATDVAKGYDL PIIHVNADDL 

       430        440        450        460        470        480 
EACIEAIEVA MAYRQKFNKD FVIDLVGYRR YGHNEMDEPT VTNPMLYKEV KGHPSIEILY 

       490        500        510        520        530        540 
GKSLVEASVI TEDEMNAIFE DVASRLRSAH DAIDKSSVNN DSEMKMPEAV EAGYEKIDTG 

       550        560        570        580        590        600 
VALEKLKQLN DDMLSIPEQF SVFNKLQKIL ERRNDPFTKD GLVDWGHAEL LAYGTIIQDG 

       610        620        630        640        650        660 
NPVRHTGQDA ERGTFAHRHA VLHDVKNGDK YIPLQHIEGA QSSFDIHNSP LSEAAVVGFE 

       670        680        690        700        710        720 
YGYNLQNNKA LTVWEAQYGD FANMAQMIFD NFISSAEAKW GEKSGLTLLL PHAYEGQGPE 

       730        740        750        760        770        780 
HSSARLERFL QLAAEHNWTV ANLSSTANYF HLLRRQAQYL GTDRMRPLVI MSPKSLLRNS 

       790        800        810        820        830        840 
FVSDTIEKFT EGSFKAIISS EYKKTKVKKL LIASGKVAVD LMTELTKNPN DEVHVIRLEQ 

       850        860        870        880        890        900 
IYPFPEQDIK AIIDDLKGLT EIGFVQEEPK NQGSWHYIYP LLNNIKPAKV KLSYYGRPYR 

       910        920 
AAPAEGDNEI HKIVQSKLIS EALNI 

« Hide

References

[1]"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC5402 EMBL BAH17771.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009484 Genomic DNA. Translation: BAH17771.1.
RefSeqYP_002560467.1. NC_011999.1.

3D structure databases

ProteinModelPortalB9EC10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458233.MCCL_1064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH17771; BAH17771; MCCL_1064.
GeneID7390741.
KEGGmcl:MCCL_1064.
PATRIC22424493. VBIMacCas48391_1189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMANEGVANE.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycMCAS458233:GI03-1075-MONOMER.

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9EC10_MACCJ
AccessionPrimary (citable) accession number: B9EC10
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)