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B9EC10

- B9EC10_MACCJ

UniProt

B9EC10 - B9EC10_MACCJ

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, MCCL_1064
Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotations

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotations

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMCAS458233:GI03-1075-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:MCCL_1064Imported
OrganismiMacrococcus caseolyticus (strain JCSC5402)Imported
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesMacrococcus
ProteomesiUP000001383: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi458233.MCCL_1064.

Structurei

3D structure databases

ProteinModelPortaliB9EC10.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

B9EC10-1 [UniParc]FASTAAdd to Basket

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MTKGKNLEEA PPRFGTNLGI LLEMFDQYQN DPSSVSDELQ ELFSNIQRGS    50
TGHSGMGSTD ADIVKRLMRL IDNIRQYGHL KADIYPLYKP KRDQHIKLSI 100
EDFGLSEEVL KQLPASLVSE HYGERLNNAF EAITEMQQTY QGPIAYEVSH 150
INNSEEREWL KTTIESKVKR DFSKEEKVEL LKSVARVEGF EKYIHKNFVG 200
AKRFSIEGVD ALVPMLENVI KFAGENNIQD IEIGMAHRGR LNVLTHILEK 250
PYEMMLSEFM HTDPMKFLPE DGSLVVKKGW TGDVKYHLGG IKTTTRFGKT 300
QTISLANNPS HLEIVAPVVL GKTRAVQEVT DGVNEPKQDF NKALAVLIHG 350
DAAFPGQGIN FESMNLSNLK GYSVGGSLHI ITNNRVGFTT ESYDSRSTTY 400
ATDVAKGYDL PIIHVNADDL EACIEAIEVA MAYRQKFNKD FVIDLVGYRR 450
YGHNEMDEPT VTNPMLYKEV KGHPSIEILY GKSLVEASVI TEDEMNAIFE 500
DVASRLRSAH DAIDKSSVNN DSEMKMPEAV EAGYEKIDTG VALEKLKQLN 550
DDMLSIPEQF SVFNKLQKIL ERRNDPFTKD GLVDWGHAEL LAYGTIIQDG 600
NPVRHTGQDA ERGTFAHRHA VLHDVKNGDK YIPLQHIEGA QSSFDIHNSP 650
LSEAAVVGFE YGYNLQNNKA LTVWEAQYGD FANMAQMIFD NFISSAEAKW 700
GEKSGLTLLL PHAYEGQGPE HSSARLERFL QLAAEHNWTV ANLSSTANYF 750
HLLRRQAQYL GTDRMRPLVI MSPKSLLRNS FVSDTIEKFT EGSFKAIISS 800
EYKKTKVKKL LIASGKVAVD LMTELTKNPN DEVHVIRLEQ IYPFPEQDIK 850
AIIDDLKGLT EIGFVQEEPK NQGSWHYIYP LLNNIKPAKV KLSYYGRPYR 900
AAPAEGDNEI HKIVQSKLIS EALNI 925
Length:925
Mass (Da):104,156
Last modified:March 24, 2009 - v1
Checksum:iCF4BA9E54754A667
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009484 Genomic DNA. Translation: BAH17771.1.
RefSeqiYP_002560467.1. NC_011999.1.

Genome annotation databases

EnsemblBacteriaiBAH17771; BAH17771; MCCL_1064.
GeneIDi7390741.
KEGGimcl:MCCL_1064.
PATRICi22424493. VBIMacCas48391_1189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009484 Genomic DNA. Translation: BAH17771.1 .
RefSeqi YP_002560467.1. NC_011999.1.

3D structure databases

ProteinModelPortali B9EC10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458233.MCCL_1064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH17771 ; BAH17771 ; MCCL_1064 .
GeneIDi 7390741.
KEGGi mcl:MCCL_1064.
PATRICi 22424493. VBIMacCas48391_1189.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci MCAS458233:GI03-1075-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
    Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
    J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC5402Imported.

Entry informationi

Entry nameiB9EC10_MACCJ
AccessioniPrimary (citable) accession number: B9EC10
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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