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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processGlycolysisUniRule annotationSAAS annotation
LigandThiamine pyrophosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:MCCL_1064Imported
OrganismiMacrococcus caseolyticus (strain JCSC5402)Imported
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeMacrococcus
Proteomesi
  • UP000001383 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi458233.MCCL_1064.

Structurei

3D structure databases

ProteinModelPortaliB9EC10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini583 – 779Transket_pyrInterPro annotationAdd BLAST197

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7P. Bacteria.
COG0567. LUCA.
HOGENOMiHOG000259588.
KOiK00164.
OMAiIDMVCYR.
OrthoDBiPOG091H03SK.

Family and domain databases

HAMAPiMF_01169. SucA_OdhA. 1 hit.
InterProiView protein in InterPro
IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiView protein in Pfam
PF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

B9EC10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGKNLEEA PPRFGTNLGI LLEMFDQYQN DPSSVSDELQ ELFSNIQRGS
60 70 80 90 100
TGHSGMGSTD ADIVKRLMRL IDNIRQYGHL KADIYPLYKP KRDQHIKLSI
110 120 130 140 150
EDFGLSEEVL KQLPASLVSE HYGERLNNAF EAITEMQQTY QGPIAYEVSH
160 170 180 190 200
INNSEEREWL KTTIESKVKR DFSKEEKVEL LKSVARVEGF EKYIHKNFVG
210 220 230 240 250
AKRFSIEGVD ALVPMLENVI KFAGENNIQD IEIGMAHRGR LNVLTHILEK
260 270 280 290 300
PYEMMLSEFM HTDPMKFLPE DGSLVVKKGW TGDVKYHLGG IKTTTRFGKT
310 320 330 340 350
QTISLANNPS HLEIVAPVVL GKTRAVQEVT DGVNEPKQDF NKALAVLIHG
360 370 380 390 400
DAAFPGQGIN FESMNLSNLK GYSVGGSLHI ITNNRVGFTT ESYDSRSTTY
410 420 430 440 450
ATDVAKGYDL PIIHVNADDL EACIEAIEVA MAYRQKFNKD FVIDLVGYRR
460 470 480 490 500
YGHNEMDEPT VTNPMLYKEV KGHPSIEILY GKSLVEASVI TEDEMNAIFE
510 520 530 540 550
DVASRLRSAH DAIDKSSVNN DSEMKMPEAV EAGYEKIDTG VALEKLKQLN
560 570 580 590 600
DDMLSIPEQF SVFNKLQKIL ERRNDPFTKD GLVDWGHAEL LAYGTIIQDG
610 620 630 640 650
NPVRHTGQDA ERGTFAHRHA VLHDVKNGDK YIPLQHIEGA QSSFDIHNSP
660 670 680 690 700
LSEAAVVGFE YGYNLQNNKA LTVWEAQYGD FANMAQMIFD NFISSAEAKW
710 720 730 740 750
GEKSGLTLLL PHAYEGQGPE HSSARLERFL QLAAEHNWTV ANLSSTANYF
760 770 780 790 800
HLLRRQAQYL GTDRMRPLVI MSPKSLLRNS FVSDTIEKFT EGSFKAIISS
810 820 830 840 850
EYKKTKVKKL LIASGKVAVD LMTELTKNPN DEVHVIRLEQ IYPFPEQDIK
860 870 880 890 900
AIIDDLKGLT EIGFVQEEPK NQGSWHYIYP LLNNIKPAKV KLSYYGRPYR
910 920
AAPAEGDNEI HKIVQSKLIS EALNI
Length:925
Mass (Da):104,156
Last modified:March 24, 2009 - v1
Checksum:iCF4BA9E54754A667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA. Translation: BAH17771.1.
RefSeqiWP_012656969.1. NC_011999.1.

Genome annotation databases

EnsemblBacteriaiBAH17771; BAH17771; MCCL_1064.
KEGGimcl:MCCL_1064.

Similar proteinsi

Entry informationi

Entry nameiB9EC10_MACCJ
AccessioniPrimary (citable) accession number: B9EC10
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 27, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported