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B9EAP9 (B9EAP9_MACCJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:MCCL_0603
OrganismMacrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]
Taxonomic identifier458233 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Macrococcus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region239 – 2435ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2381 By similarity HAMAP MF_01815
Active site2681 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B9EAP9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 277F8B5A669C1D92

FASTA31734,838
        10         20         30         40         50         60 
MNAGIIGIGT YVPEMIIDNH YFENYLETTD EWIVSRTGIK ERRFADQDMD VSDMAYYAAL 

        70         80         90        100        110        120 
QAIEDAAIKP EDIDLILVAT STGDHHFPSV ACQLQHRLKL SKVPAMDQLA ACTGFIYSLI 

       130        140        150        160        170        180 
TAQQFILSGN YRNILVVGAD KLSKITNMED RNTAVLFGDG AGAVIVSQVS DNYGIQAYSW 

       190        200        210        220        230        240 
GSDGSGAFHL YDDKESGYLK MNGREVFKFA VRILEEQSQL VMNKAGLHAQ DIDMLIPHQA 

       250        260        270        280        290        300 
NTRIIESARE RLGLSASQVS TTLDKYGNTS AASIPLSIAY EYQNGKIKNG DQLILTGFGG 

       310 
GLTFGAIALI WGQEEKR

« Hide

References

[1]"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
J. Bacteriol. 191:1180-1190(2009) [PubMed: 19074389] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009484 Genomic DNA. Translation: BAH17310.1.
RefSeqYP_002560006.1. NC_011999.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB9EAP9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7390225.
GenomeReviewsGene locus MCCL_0603 in contig AP009484_GR.
KEGGmcl:MCCL_0603.
PATRIC22423504. VBIMacCas48391_0695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMADAYIRGG.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9EAP9_MACCJ
AccessionPrimary (citable) accession number: B9EAP9
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info