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B9EA92 (UPPP_MACCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:MCCL_0446
OrganismMacrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]
Taxonomic identifier458233 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesMacrococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148818

Regions

Transmembrane49 – 6921Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B9EA92 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 96F5780DE877A159

FASTA28131,003
        10         20         30         40         50         60 
MTFFELVKAL ILGIVEGLTE FAPVSSTGHQ ILVDDMWLQT KYVLNSQESA NTFKIVIQLG 

        70         80         90        100        110        120 
SIFAAAWIFR HRFLEVLHIE KTKTEGPRLN LLHIFIGLIP AGIMGLLFDD FIDKHLFSVP 

       130        140        150        160        170        180 
TVLIGLALGA LLMIAADLFN KKVTHTTTVD EMTYKQALII GVAQCLALWP GFSRSGSTIS 

       190        200        210        220        230        240 
AGVLLKMNHK AASDFTFIMA VPIMFAASAK SLASNIQYIH SDQILFYIVG FIAAFIFGVL 

       250        260        270        280 
SIRLFLSLIN RVKLMPFAIY RLILVAVIAV LYFGFGIGKG I 

« Hide

References

[1]"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC5402.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009484 Genomic DNA. Translation: BAH17153.1.
RefSeqYP_002559849.1. NC_011999.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458233.MCCL_0446.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH17153; BAH17153; MCCL_0446.
GeneID7390651.
KEGGmcl:MCCL_0446.
PATRIC22423176. VBIMacCas48391_0531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMCAS458233:GI03-459-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MACCJ
AccessionPrimary (citable) accession number: B9EA92
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families