B9EA92 (UPPP_MACCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	MCCL_0446

Organism

Macrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]

Taxonomic identifier

458233 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Macrococcus › Macrococcus caseolyticus

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000148818
Regions
	Transmembrane	49 – 69	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B9EA92 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 96F5780DE877A159	FASTA	281	31,003
	10 20 30 40 50 60 MTFFELVKAL ILGIVEGLTE FAPVSSTGHQ ILVDDMWLQT KYVLNSQESA NTFKIVIQLG 70 80 90 100 110 120 SIFAAAWIFR HRFLEVLHIE KTKTEGPRLN LLHIFIGLIP AGIMGLLFDD FIDKHLFSVP 130 140 150 160 170 180 TVLIGLALGA LLMIAADLFN KKVTHTTTVD EMTYKQALII GVAQCLALWP GFSRSGSTIS 190 200 210 220 230 240 AGVLLKMNHK AASDFTFIMA VPIMFAASAK SLASNIQYIH SDQILFYIVG FIAAFIFGVL 250 260 270 280 SIRLFLSLIN RVKLMPFAIY RLILVAVIAV LYFGFGIGKG I

References

[1]

"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci." Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K. J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC5402.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009484 Genomic DNA. Translation: BAH17153.1.
RefSeq	YP_002559849.1. NC_011999.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	458233.MCCL_0446.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAH17153; BAH17153; MCCL_0446.
GeneID	7390651.
KEGG	mcl:MCCL_0446.
PATRIC	22423176. VBIMacCas48391_0531.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	LQIGLFQ.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	MCAS458233:GI03-380-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_MACCJ

Accession

Primary (citable) accession number: B9EA92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program