ID   B9EA36_MACCJ            Unreviewed;       492 AA.
AC   B9EA36;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:BAH17097.1};
GN   Name=aldA {ECO:0000313|EMBL:BAH17097.1};
GN   OrderedLocusNames=MCCL_0390 {ECO:0000313|EMBL:BAH17097.1};
OS   Macrococcus caseolyticus (strain JCSC5402).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX   NCBI_TaxID=458233 {ECO:0000313|EMBL:BAH17097.1, ECO:0000313|Proteomes:UP000001383};
RN   [1] {ECO:0000313|EMBL:BAH17097.1, ECO:0000313|Proteomes:UP000001383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC5402 {ECO:0000313|EMBL:BAH17097.1,
RC   ECO:0000313|Proteomes:UP000001383};
RX   PubMed=19074389; DOI=10.1128/JB.01058-08;
RA   Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT   "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT   reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL   J. Bacteriol. 191:1180-1190(2009).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AP009484; BAH17097.1; -; Genomic_DNA.
DR   RefSeq; WP_012656298.1; NC_011999.1.
DR   AlphaFoldDB; B9EA36; -.
DR   STRING; 458233.MCCL_0390; -.
DR   KEGG; mcl:MCCL_0390; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_2_9; -.
DR   OrthoDB; 9762913at2; -.
DR   Proteomes; UP000001383; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001383}.
FT   DOMAIN          20..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   COILED          67..94
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   ACT_SITE        252
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   492 AA;  53677 MW;  9C9FC507757F88F1 CRC64;
     MSNLLKEQYG LFINGEFKDS AAGETLDVTN PATGEVLAKI AKATEQDVDA AVKSAEEAFK
     TWRHTSHNEK AKLLNQIADK MEEHREELAK IESLNSGKAI RESLNIDIPM AIEHFRYFAG
     VILADEGTNK EIDADAISII KHEPIGVVGA VVAWNFPMLL ASWKLAPALA AGNAVVIQPS
     SSTPLSLLKF AEIVQDILPK GVLNVVTGKG SESGNAIFNH EDVAKVSFTG STEVGYGVAE
     AAAKRIVPAT LELGGKSANI IFDDANIEQA IEGAQLGILF NQGEVCSAGS RLYVQEGIYD
     EFVAKLKDAF EKVRVGDPMD ENNHYGSQTG QAQIDKIEEY IEVAKQEGLN IVTGGKRLMD
     NGRDKGFFFP PTIIEFEDNK SRLVQEEIFG PVVLVSKFKT KEEVIEKAND SEYGLAGGIF
     TANLNDALQV ANAMDTGRIW INTYNQIPAG SPFGGYKKSG IGRETYKDTL RHYQQVKNIY
     IDYSDKAKGI YQ
//