B9E8U9 (PTH_MACCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	MCCL_1910

Organism

Macrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]

Taxonomic identifier

458233 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Macrococcus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000118396

Sequences

	Sequence		Length	Mass (Da)
	B9E8U9 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: CA5F51980D285ACB	FASTA	189	21,423
	10 20 30 40 50 60 MKCIVGLGNI GKKYELTRHN IGFMVVDRLV ESYNLELNQQ KFKGLYAIAM INGEKVLLIE 70 80 90 100 110 120 PMTYMNSSGE AVRPLMDYFN VSTEDLLVLY DDLDMPPGRL RLRQKGSAGG HNGIRSLIQH 130 140 150 160 170 180 LGTDQFKRIR IGIGRPTGHL KVVDFVLQKF TPDEMIVMDK VINQTIKAVE AFIAGERFEN IMNQYNGDV

References

[1]

"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci." Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K. J. Bacteriol. 191:1180-1190(2009) [PubMed: 19074389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC5402.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009484 Genomic DNA. Translation: BAH18617.1.
RefSeq	YP_002561313.1. NC_011999.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9E8U9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7390685.
GenomeReviews	Gene locus MCCL_1910 in contig AP009484_GR.
KEGG	mcl:MCCL_1910.
PATRIC	22426311. VBIMacCas48391_2054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SHAGHNG.
ProtClustDB	PRK05426.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_MACCJ

Accession

Primary (citable) accession number: B9E8U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program