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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei176May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:MCCL_1847
OrganismiMacrococcus caseolyticus (strain JCSC5402)
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeMacrococcus
Proteomesi
  • UP000001383 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001851541 – 292GTP cyclohydrolase FolE2Add BLAST292

Interactioni

Protein-protein interaction databases

STRINGi458233.MCCL_1847

Structurei

3D structure databases

SMRiB9E8N6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

B9E8N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYNLNTRE GRWKHFGSVD PIKGTKPTEK EKMTDLQSSK KDFLFEIDHV
60 70 80 90 100
GIKNLTYPVR LDGYQTAGTF SLSTHLAKDE KGINMSRILE SVEAHYDNGL
110 120 130 140 150
SLDFDTLKTV LITLQTVMHQ KDATVDVDAK WFFDRFSPVT NLRAIGHADT
160 170 180 190 200
RFSMTVEGDT TVNKSLTLTA MVTTLCPCSK EISEYSAHNQ RGIVTVKADF
210 220 230 240 250
APEGELPANF KERILEAMEV NASSMLYPIL KRTDEKSVTE RAYENPRFVE
260 270 280 290
DLLRLIAADL VELDFVTGFT IECRNEESIH QHDAFARLSY NK
Length:292
Mass (Da):33,158
Last modified:March 24, 2009 - v1
Checksum:iB1EA89CFCF97AAED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA Translation: BAH18554.1
RefSeqiWP_015912346.1, NC_011999.1

Genome annotation databases

EnsemblBacteriaiBAH18554; BAH18554; MCCL_1847
KEGGimcl:MCCL_1847

Similar proteinsi

Entry informationi

Entry nameiGCH4_MACCJ
AccessioniPrimary (citable) accession number: B9E8N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health