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Protein

Thymidine kinase

Gene

tdk

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MCCL_1773
OrganismiMacrococcus caseolyticus (strain JCSC5402)
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeMacrococcus
Proteomesi
  • UP000001383 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001226561 – 191Thymidine kinaseAdd BLAST191

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi458233.MCCL_1773.

Structurei

3D structure databases

ProteinModelPortaliB9E8G2.
SMRiB9E8G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiFKGKPFG.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9E8G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEHYHSGWI ECVTGSMFSG KSEELIRRVR RGLFAKQKVI VFKPSIDDRY
60 70 80 90 100
SELEVVSHNG NKVEAVNVHH SSEILEHVKE AHDIIAIDEV QFFDNDIVGV
110 120 130 140 150
ATQLAEEGYR VIVAGLDMDF RGVPFEPVPE LMAVSEHVTK LQAVCSVCGA
160 170 180 190
PSSRTQRLID GVPAKFDDPI ILVGAKESYE PRCREHHVVP K
Length:191
Mass (Da):21,438
Last modified:March 24, 2009 - v1
Checksum:i3FC553CA84CA9F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA. Translation: BAH18480.1.
RefSeqiWP_015912272.1. NC_011999.1.

Genome annotation databases

EnsemblBacteriaiBAH18480; BAH18480; MCCL_1773.
KEGGimcl:MCCL_1773.
PATRICi22426031. VBIMacCas48391_1915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA. Translation: BAH18480.1.
RefSeqiWP_015912272.1. NC_011999.1.

3D structure databases

ProteinModelPortaliB9E8G2.
SMRiB9E8G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi458233.MCCL_1773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH18480; BAH18480; MCCL_1773.
KEGGimcl:MCCL_1773.
PATRICi22426031. VBIMacCas48391_1915.

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiFKGKPFG.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_MACCJ
AccessioniPrimary (citable) accession number: B9E8G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.