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B9E8D6 (THIM_MACCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:MCCL_1747
OrganismMacrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]
Taxonomic identifier458233 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesMacrococcus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383885

Sites

Binding site391Substrate; via amide nitrogen By similarity
Binding site1151ATP By similarity
Binding site1591ATP By similarity
Binding site1861Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B9E8D6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: C3FA65BA7B93931D

FASTA26128,005
        10         20         30         40         50         60 
MVKLNQLRKD NPLIICITND VVKNFTANGL LALGASPAMA TERQEMDEFL AHAGALLINI 

        70         80         90        100        110        120 
GSIEEGDKEN MLQAAAFANK HHVPIVLDPV ACGASKFRKD FCLRLLNEHH ISIIRGNASE 

       130        140        150        160        170        180 
LAALTDDATM KGTDADQSLS TESVARRAYD KFKTAIIATG AVDAICQDEQ IMLVENGTPM 

       190        200        210        220        230        240 
LTKVTGGGCL LGAVVASFIY NETKPSLALL TEAIATYTIA AERAAHSANG TLPGHFAVNL 

       250        260 
IDQLYLIQQD DIAKESRVKE V 

« Hide

References

[1]"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC5402.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009484 Genomic DNA. Translation: BAH18454.1.
RefSeqYP_002561150.1. NC_011999.1.

3D structure databases

ProteinModelPortalB9E8D6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458233.MCCL_1747.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH18454; BAH18454; MCCL_1747.
GeneID7390466.
KEGGmcl:MCCL_1747.
PATRIC22425977. VBIMacCas48391_1888.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycMCAS458233:GI03-1797-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_MACCJ
AccessionPrimary (citable) accession number: B9E8D6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways