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B9E8C9 (B9E8C9_MACCJ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF EMBL BAH18447.1
Ordered Locus Names:MCCL_1740 EMBL BAH18447.1
OrganismMacrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP] EMBL BAH18447.1
Taxonomic identifier458233 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Macrococcus ›

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
B9E8C9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: F58B2DDA9E16AB70

FASTA44749,471
        10         20         30         40         50         60 
MIMINRSLNW IKKHTTGTLD AMYEEVMISG VSIDSRNIHE GVLFIPFKGE HVDGHKYVAD 

        70         80         90        100        110        120 
AIDKGAYAAL WQRDAGEVPR DLPVIVVEDT LTALQQLSKA YLKEVDPKVI AVTGSNGKTT 

       130        140        150        160        170        180 
TKDMIEAVLS PHFKVKKTQG NYNNEIGLPL TLCQLDEDTE ISILEMGMSG FGEISLLSHI 

       190        200        210        220        230        240 
AEPHIAAITN IGESHMRDLG SREGIAKAKY EITDGLTGPL FYDGDEALLK PLVKDNKDAH 

       250        260        270        280        290        300 
RIGFNEDNEY YIHEMIMQDK HLQFKVNDDT YIVPTLGSHN ARNATIAIAI GSYLGLSPEQ 

       310        320        330        340        350        360 
INHSLQQLKL TGMRMEQLEG KDGALLINDA YNASPTSMKA AIDTVSQMDS EVKIIVFGDV 

       370        380        390        400        410        420 
LELGEDEVMY HEQVGAYLQG KQIDYVFTTG NAARHISKAA EPFTTVQHFD TKEALTNHLK 

       430        440 
GMLNAHTSVL FKASRGMKLE TIINELL

« Hide

References

[1]"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci."
Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC5402 EMBL BAH18447.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009484 Genomic DNA. Translation: BAH18447.1.
RefSeqYP_002561143.1. NC_011999.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING458233.MCCL_1740.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH18447; BAH18447; MCCL_1740.
GeneID7390831.
KEGGmcl:MCCL_1740.
PATRIC22425961. VBIMacCas48391_1880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268119.
KOK01929.
OMAGNRNNEI.
ProtClustDBCLSK885754.

Enzyme and pathway databases

BioCycMCAS458233:GI03-1719-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9E8C9_MACCJ
AccessionPrimary (citable) accession number: B9E8C9
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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