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B9E7H4

- SYL_MACCJ

UniProt

B9E7H4 - SYL_MACCJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei577 – 5771ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMCAS458233:GI03-1448-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MCCL_1435
    OrganismiMacrococcus caseolyticus (strain JCSC5402)
    Taxonomic identifieri458233 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesMacrococcus
    ProteomesiUP000001383: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 802802Leucine--tRNA ligasePRO_1000199213Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi458233.MCCL_1435.

    Structurei

    3D structure databases

    ProteinModelPortaliB9E7H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi574 – 5785"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9E7H4-1 [UniParc]FASTAAdd to Basket

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    MSFNHQTIEK KWQKYWLDNH TFKTTEDKDK NFYALDMFPY PSGAGLHVGH    50
    PEGYTATDII SRFKRMQGYN VLHPMGWDAF GLPAEQYAID TGNDPAEFTE 100
    KNIATFKRQI QELGFSYDWE REINTTDPEY YKWTQWIFIQ LYKKGLAYVD 150
    EVAVNWCPAL GTVLSNEEVI DGVSERGGHP VIRKPMRQWV LKITEYADRL 200
    LEDLEELDWP ESLKDMQRNW IGRSEGAEVA FEVENLDHSF KVFTTRPDTI 250
    YGATYAVLSP EHELVAAITS EEQAEAVKAY QEQAARKSDL ERTDLAKDKT 300
    GVFTGSYAIN PFNGERMPIW ISDYVLASYG TGAIMAVPAH DERDFEFAKQ 350
    FGLDIKPVIE GGDNTSAYTG DGAHINSGEL DGLNKEEGIR RAIELLEAKG 400
    IGEKKVSYKL RDWLFSRQRY WGEPIPVITW EDGSMTTVPE EELPLMLPKT 450
    EHIKPSGTGE SPLANIDEFV NVTDPVTGMK GRRETNTMPQ WAGSCWYYLR 500
    YIDPKNSDMI ADPELLKKWL PVDLYIGGAE HAVLHLLYAR FWHKVLYDLG 550
    VVHTKEPFQK LFNQGMILGE GNEKMSKSKG NVVNPDDVVA SHGADTLRLY 600
    EMFMGPLDAS IAWSTNGLDG ARRFLDRVYR LLVNEDGTLS EKITEQPVGS 650
    MEKVYHQTVK KVTDDYETLG FNTAISQMMV FINEGYKSEQ LNIDHIRGFV 700
    KLLNPIAPHI TEELWEKLGG TESITYEAWP VYDESKLVDS EVEIVIQVNG 750
    KLKQKATIAK DMDKSEMETF ALSLEAVQTA IEGKTVRKVI AVPNKLVNIV 800
    AN 802
    Length:802
    Mass (Da):91,101
    Last modified:March 24, 2009 - v1
    Checksum:i456BBFFEAA2D2A37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009484 Genomic DNA. Translation: BAH18142.1.
    RefSeqiYP_002560838.1. NC_011999.1.

    Genome annotation databases

    EnsemblBacteriaiBAH18142; BAH18142; MCCL_1435.
    GeneIDi7389403.
    KEGGimcl:MCCL_1435.
    PATRICi22425257. VBIMacCas48391_1569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009484 Genomic DNA. Translation: BAH18142.1 .
    RefSeqi YP_002560838.1. NC_011999.1.

    3D structure databases

    ProteinModelPortali B9E7H4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 458233.MCCL_1435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH18142 ; BAH18142 ; MCCL_1435 .
    GeneIDi 7389403.
    KEGGi mcl:MCCL_1435.
    PATRICi 22425257. VBIMacCas48391_1569.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MCAS458233:GI03-1448-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
      Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
      J. Bacteriol. 191:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCSC5402.

    Entry informationi

    Entry nameiSYL_MACCJ
    AccessioniPrimary (citable) accession number: B9E7H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3