B9E7E7 (B9E7E7_MACCJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	MCCL_1408

Organism

Macrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]

Taxonomic identifier

458233 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Macrococcus

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B9E7E7 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: F21F2E7CDACC6D82	FASTA	555	59,952
	10 20 30 40 50 60 MTKYLSDLEI ANQATIKPIA EIAEAAGIPD NAVEPYGHYK AKIDTSKVTT DKQGKVVLVT 70 80 90 100 110 120 AMSPTPAGEG KSTVTVGISD AFKALGKNVM VALREPSLGP VFGMKGGATG GGHAQVLPME 130 140 150 160 170 180 EINLHFNGDL HAITTANNAL AAFIDNHIYQ GNKLNIDPRR VEWKRVIDMN DRALRQVVVG 190 200 210 220 230 240 LGGPFKGVPR EDGFDITVAS EIMAVFCLSN NIEDLKENLG KMTIGYTYDR KPVTVKELGV 250 260 270 280 290 300 EGALALILKD ALKPNLVQTI EGTPALIHGG PFANIAHGCN SIIATKTARK LADIVVTESG 310 320 330 340 350 360 FGSDLGAEKF MDIKARKADI QPDAIVVVAT IRALKMHGGV AKTELSAENV EALKSGIQNL 370 380 390 400 410 420 EKHIENLNQF GVESVIALNN FVTDTDAERE FVIKWAKERG VKLALTEVWE HGGEGGKDLA 430 440 450 460 470 480 NLVLEVLEQP QSFKPLYDLS LPVEEKIRTI VQKIYGADDV VFTDKAKKQL KTITDNGWNE 490 500 510 520 530 540 YPVCMAKTQY SFSDDPKKLG RPSGFEITIR ELIPKTGAGF IVALTGDIMT MPGLPKEPAA 550 LRMDVDKEGN AVGLF

References

[1]

"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci." Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K. J. Bacteriol. 191:1180-1190(2009) [PubMed: 19074389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009484 Genomic DNA. Translation: BAH18115.1.
RefSeq	YP_002560811.1. NC_011999.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9E7E7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7389380.
GenomeReviews	Gene locus MCCL_1408 in contig AP009484_GR.
KEGG	mcl:MCCL_1408.
PATRIC	22425201. VBIMacCas48391_1541.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9E7E7_MACCJ

Accession

Primary (citable) accession number: B9E7E7

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)