B9E6Y4 (AROE_MACCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	MCCL_1245

Organism

Macrococcus caseolyticus (strain JCSC5402) [Complete proteome] [HAMAP]

Taxonomic identifier

458233 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Macrococcus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000124890
Regions
	Nucleotide binding	121 – 125	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B9E6Y4 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 30E1399592E82D17	FASTA	267	29,542
	10 20 30 40 50 60 MKFAVIGHPI KHSLSPLMHH ANFNALQTDD EYAALHIDPK HFHHLRDIIH EKAIDGFNIT 70 80 90 100 110 120 IPYKVDMLQV VDVVDIKAQM IGAINTVHIE DGIWYGYNTD GAGFKASIEK YTGGKNIVIL 130 140 150 160 170 180 GAGGASRAIC YTLFKDNKVT VLNRNTNRVA DWPFQIDAYT YEESDGVIQQ ADIVINTTPV 190 200 210 220 230 240 GMEGFMPDTL IDISQLKSSA VVCDIIYTPD KTPILQSAAQ RGLSVINGLD MFVNQGALSY 250 260 EIWTGKKANK AAMKQAVINY LQRSTLC

References

[1]

"Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci." Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K. J. Bacteriol. 191:1180-1190(2009) [PubMed: 19074389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC5402.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009484 Genomic DNA. Translation: BAH17952.1.
RefSeq	YP_002560648.1. NC_011999.1.
3D structure databases
ProteinModelPortal	B9E6Y4.
ModBase	Search...
Protein-protein interaction databases
STRING	B9E6Y4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7389188.
GenomeReviews	Gene locus MCCL_1245 in contig AP009484_GR.
KEGG	mcl:MCCL_1245.
PATRIC	22424869. VBIMacCas48391_1377.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SVGMYPN.
ProtClustDB	CLSK885454.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_MACCJ

Accession

Primary (citable) accession number: B9E6Y4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program