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B9E5W0

- SYT_CLOK1

UniProt

B9E5W0 - SYT_CLOK1

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Clostridium kluyveri (strain NBRC 12016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi333 – 3331Zinc; catalyticUniRule annotation
    Metal bindingi384 – 3841Zinc; catalyticUniRule annotation
    Metal bindingi509 – 5091Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCKLU583346:GJNQ-2883-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:CKR_2834
    OrganismiClostridium kluyveri (strain NBRC 12016)
    Taxonomic identifieri583346 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000007969: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 637637Threonine--tRNA ligasePRO_1000199538Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi583346.CKR_2834.

    Structurei

    3D structure databases

    ProteinModelPortaliB9E5W0.
    SMRiB9E5W0. Positions 241-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 532291CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003879.
    KOiK01868.
    OrthoDBiEOG61KBFJ.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9E5W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKISLKNGK EIEVEKGLKV IDIAAKLSIS LSKKALGAVV DGKVVELNYK    50
    INKDCKVEIL TFEDEEGKKI LRHTASHILA QAIKRLYPEV KLAIGPAIDS 100
    GFYYDVDAEF SFTPELLEKI EGKMNEIIKE NIKLERFELP REEAIKFMEE 150
    KNEPYKVELI KDLPEDSIIS FYKQGDFVDL CAGPHVPSTG RAKAVKLLSI 200
    AGAYWRGNEN NKMLQRIYGT VFEKKSDLQD YLKLMEEAKK RDHRKLGKEL 250
    DLFSIHEEGP GFPFFHPKGM VIRNTLQNFW REMHYKADYS EIMTPIILNE 300
    ELWHRSGHWD HYKENMYFTK IDDGNYAIKP MNCPGSILVY KNDIRSYRDL 350
    PKRYAEMGVV HRHEKSGALH GLMRVRCFTQ DDAHIFVTKD DIADEIIKVI 400
    DLIDNFYKIF GFEYFVELST RPEDSMGSDE DWEAATEGLK NALKMVGLDY 450
    KINEGDGAFY GPKIDFHLKD CIGRTWQCGT VQLDFQMPEK FDLNYIGADG 500
    EKHRPVMIHR VVFGSIERFI GILIEHYAGA FPAWIAPVQV QVMNITDAQA 550
    DYVAEVAKTL KENNIRVECD IRNEKIGYKI REAQMHKVPY MIILGDKEMK 600
    DKNISVRSRK EGDIGAMSLE DFILKLKEEI DKKISHV 637
    Length:637
    Mass (Da):73,463
    Last modified:March 24, 2009 - v1
    Checksum:i4BD227D00D952C0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07885.1.
    RefSeqiYP_002473299.1. NC_011837.1.

    Genome annotation databases

    EnsemblBacteriaiBAH07885; BAH07885; CKR_2834.
    GeneIDi7275302.
    KEGGickr:CKR_2834.
    PATRICi19475913. VBICloKlu118830_3199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07885.1 .
    RefSeqi YP_002473299.1. NC_011837.1.

    3D structure databases

    ProteinModelPortali B9E5W0.
    SMRi B9E5W0. Positions 241-633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 583346.CKR_2834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH07885 ; BAH07885 ; CKR_2834 .
    GeneIDi 7275302.
    KEGGi ckr:CKR_2834.
    PATRICi 19475913. VBICloKlu118830_3199.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003879.
    KOi K01868.
    OrthoDBi EOG61KBFJ.

    Enzyme and pathway databases

    BioCyci CKLU583346:GJNQ-2883-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
      Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 12016.

    Entry informationi

    Entry nameiSYT_CLOK1
    AccessioniPrimary (citable) accession number: B9E5W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3