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B9E5W0

- SYT_CLOK1

UniProt

B9E5W0 - SYT_CLOK1

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Protein
Threonine--tRNA ligase
Gene
thrS, CKR_2834
Organism
Clostridium kluyveri (strain NBRC 12016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi333 – 3331Zinc; catalytic By similarity
Metal bindingi384 – 3841Zinc; catalytic By similarity
Metal bindingi509 – 5091Zinc; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCKLU583346:GJNQ-2883-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:thrS
Ordered Locus Names:CKR_2834
OrganismiClostridium kluyveri (strain NBRC 12016)
Taxonomic identifieri583346 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000007969: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Threonine--tRNA ligaseUniRule annotation
PRO_1000199538Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi583346.CKR_2834.

Structurei

3D structure databases

ProteinModelPortaliB9E5W0.
SMRiB9E5W0. Positions 241-633.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 532291CatalyticUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0441.
HOGENOMiHOG000003879.
KOiK01868.
OrthoDBiEOG61KBFJ.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9E5W0-1 [UniParc]FASTAAdd to Basket

« Hide

MIKISLKNGK EIEVEKGLKV IDIAAKLSIS LSKKALGAVV DGKVVELNYK    50
INKDCKVEIL TFEDEEGKKI LRHTASHILA QAIKRLYPEV KLAIGPAIDS 100
GFYYDVDAEF SFTPELLEKI EGKMNEIIKE NIKLERFELP REEAIKFMEE 150
KNEPYKVELI KDLPEDSIIS FYKQGDFVDL CAGPHVPSTG RAKAVKLLSI 200
AGAYWRGNEN NKMLQRIYGT VFEKKSDLQD YLKLMEEAKK RDHRKLGKEL 250
DLFSIHEEGP GFPFFHPKGM VIRNTLQNFW REMHYKADYS EIMTPIILNE 300
ELWHRSGHWD HYKENMYFTK IDDGNYAIKP MNCPGSILVY KNDIRSYRDL 350
PKRYAEMGVV HRHEKSGALH GLMRVRCFTQ DDAHIFVTKD DIADEIIKVI 400
DLIDNFYKIF GFEYFVELST RPEDSMGSDE DWEAATEGLK NALKMVGLDY 450
KINEGDGAFY GPKIDFHLKD CIGRTWQCGT VQLDFQMPEK FDLNYIGADG 500
EKHRPVMIHR VVFGSIERFI GILIEHYAGA FPAWIAPVQV QVMNITDAQA 550
DYVAEVAKTL KENNIRVECD IRNEKIGYKI REAQMHKVPY MIILGDKEMK 600
DKNISVRSRK EGDIGAMSLE DFILKLKEEI DKKISHV 637
Length:637
Mass (Da):73,463
Last modified:March 24, 2009 - v1
Checksum:i4BD227D00D952C0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009049 Genomic DNA. Translation: BAH07885.1.
RefSeqiYP_002473299.1. NC_011837.1.

Genome annotation databases

EnsemblBacteriaiBAH07885; BAH07885; CKR_2834.
GeneIDi7275302.
KEGGickr:CKR_2834.
PATRICi19475913. VBICloKlu118830_3199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009049 Genomic DNA. Translation: BAH07885.1 .
RefSeqi YP_002473299.1. NC_011837.1.

3D structure databases

ProteinModelPortali B9E5W0.
SMRi B9E5W0. Positions 241-633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 583346.CKR_2834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH07885 ; BAH07885 ; CKR_2834 .
GeneIDi 7275302.
KEGGi ckr:CKR_2834.
PATRICi 19475913. VBICloKlu118830_3199.

Phylogenomic databases

eggNOGi COG0441.
HOGENOMi HOG000003879.
KOi K01868.
OrthoDBi EOG61KBFJ.

Enzyme and pathway databases

BioCyci CKLU583346:GJNQ-2883-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
SMARTi SM00863. tRNA_SAD. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
    Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 12016.

Entry informationi

Entry nameiSYT_CLOK1
AccessioniPrimary (citable) accession number: B9E5W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi