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B9E564

- THIM_CLOK1

UniProt

B9E564 - THIM_CLOK1

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Clostridium kluyveri (strain NBRC 12016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481Substrate; via amide nitrogenUniRule annotation
    Binding sitei124 – 1241ATPUniRule annotation
    Binding sitei170 – 1701ATPUniRule annotation
    Binding sitei197 – 1971Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCKLU583346:GJNQ-2634-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:CKR_2588
    OrganismiClostridium kluyveri (strain NBRC 12016)
    Taxonomic identifieri583346 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000007969: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Hydroxyethylthiazole kinasePRO_1000198114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi583346.CKR_2588.

    Structurei

    3D structure databases

    ProteinModelPortaliB9E564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9E564-1 [UniParc]FASTAAdd to Basket

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    MNDLKLDKVS KVLKEVRKSV PLVHCITNYV TINDCANILL SYGASPAMCE    50
    AYDEVFDFVK ISSALYINIG TFTREQESSA ILAAVSAKTH NIPVVLDPVA 100
    CAAIPKKIQF IDKLFKVGRV DVIKGNIGEI KFLAGETSNV KGVDSLEDGE 150
    GALECSRILS EKYNCVVAAT GKKDFIVQGK NSAIIENGTE MLTNITGAGC 200
    MLGALCAAAC GAFEDKFMAV VGAILSINIA SEEAYKEAKA PGSFRVKLID 250
    CIYELSEEKL KKEGKIAWN 269
    Length:269
    Mass (Da):28,946
    Last modified:March 24, 2009 - v1
    Checksum:i27ABE775AC3BC4AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07639.1.
    RefSeqiWP_012103262.1. NC_011837.1.
    YP_002473053.1. NC_011837.1.

    Genome annotation databases

    EnsemblBacteriaiBAH07639; BAH07639; CKR_2588.
    GeneIDi7273005.
    KEGGickr:CKR_2588.
    PATRICi19475352. VBICloKlu118830_2922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07639.1 .
    RefSeqi WP_012103262.1. NC_011837.1.
    YP_002473053.1. NC_011837.1.

    3D structure databases

    ProteinModelPortali B9E564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 583346.CKR_2588.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH07639 ; BAH07639 ; CKR_2588 .
    GeneIDi 7273005.
    KEGGi ckr:CKR_2588.
    PATRICi 19475352. VBICloKlu118830_2922.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci CKLU583346:GJNQ-2634-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
      Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 12016.

    Entry informationi

    Entry nameiTHIM_CLOK1
    AccessioniPrimary (citable) accession number: B9E564
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3