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B9E4K6

- PUR9_CLOK1

UniProt

B9E4K6 - PUR9_CLOK1

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium kluyveri (strain NBRC 12016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCKLU583346:GJNQ-2425-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:CKR_2380
    OrganismiClostridium kluyveri (strain NBRC 12016)
    Taxonomic identifieri583346 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000007969: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Bifunctional purine biosynthesis protein PurHPRO_1000122954Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi583346.CKR_2380.

    Structurei

    3D structure databases

    ProteinModelPortaliB9E4K6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9E4K6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINRALISVY NKEGLLELAQ FLKNKGVELI STGGTYKYLE QNDIQVTEVS    50
    KITGFDEILD GRVKTLHPVI HSGILAKRDN KEHMDTIAKK DILPIDMVVV 100
    NLYPFFDKVD DNITFEEKVE FIDIGGPTMI RAAAKNFKDV IVVTDVGDYS 150
    KLIEEIDSKG DVPYDFRKKL AGKVFNLMSA YDGAISNFLL EEDYPEYLSL 200
    SYKKMDNLRY GENPHQSAAY YTATAGTAPM KDFTQLNGKQ LSYNNIKDMD 250
    IAWKVVNEFE EICCVAVKHN TPCGVALGKD LYEAYVKTYE CDPTSIFGGI 300
    IAVNRKLDVK TAEEISKIFV EIVIAPDFDE EALKVLMEKK NLRIIKCSVK 350
    PTNSMEIAKV DGGILVQSAD DKLVENMEVV TDKKPSKEEI NNLIFGMKVC 400
    KYVKSNAIVV VKDFMAKGIG GGQVNRIWPT CHALDRAGDG VVLASDAFFP 450
    FNDVVCEAAK YGIKAIIQPG GSVRDKDSIE ECNKNGISMV FTGVRHFKH 499
    Length:499
    Mass (Da):55,653
    Last modified:March 24, 2009 - v1
    Checksum:iC01A33D8D18AD82A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07431.1.
    RefSeqiWP_012103026.1. NC_011837.1.
    YP_002472845.1. NC_011837.1.

    Genome annotation databases

    EnsemblBacteriaiBAH07431; BAH07431; CKR_2380.
    GeneIDi7273527.
    KEGGickr:CKR_2380.
    PATRICi19474870. VBICloKlu118830_2682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009049 Genomic DNA. Translation: BAH07431.1 .
    RefSeqi WP_012103026.1. NC_011837.1.
    YP_002472845.1. NC_011837.1.

    3D structure databases

    ProteinModelPortali B9E4K6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 583346.CKR_2380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH07431 ; BAH07431 ; CKR_2380 .
    GeneIDi 7273527.
    KEGGi ckr:CKR_2380.
    PATRICi 19474870. VBICloKlu118830_2682.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CKLU583346:GJNQ-2425-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
      Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 12016.

    Entry informationi

    Entry nameiPUR9_CLOK1
    AccessioniPrimary (citable) accession number: B9E4K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3