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B9DYW1

- FTHS_CLOK1

UniProt

B9DYW1 - FTHS_CLOK1

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium kluyveri (strain NBRC 12016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKLU583346:GJNQ-418-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CKR_0385
OrganismiClostridium kluyveri (strain NBRC 12016)
Taxonomic identifieri583346 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000007969: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000185253Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi583346.CKR_0385.

Structurei

3D structure databases

ProteinModelPortaliB9DYW1.
SMRiB9DYW1. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9DYW1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFKSDIQIA QECSMENIKD IAKKLNIFED EIELYGKYKA KIDYNLLKTT
60 70 80 90 100
KGKNGKLILC TAINPTPAGE GKTTTSIGVA DALARLDKSV VVALREPSMG
110 120 130 140 150
PVFGIKGGAA GGGYAQVVPM EDINLHFTGD IHAMTAANNL LAALIDNHIY
160 170 180 190 200
QGNKLNIDSR RVVWRRCVDM NDRQLRFVVD GLGGKVNGIP REDGFDITVA
210 220 230 240 250
SEIMAIFCLS TDINDLKERI SKIVVGYTTE GNPVTAHDLK AEGAMAALLK
260 270 280 290 300
DALKPNLVQT LEGTPAFVHG GPFANIAHGC NSIMATRMAM HFGDYVVTEA
310 320 330 340 350
GFGADLGAEK FLDIKCRMAG LRPDAVIIVA TVRALKYNGG TPKTKLNNEN
360 370 380 390 400
LETLEKGIPN LLKHVENITK VFKLPAVVAL NAFPTDTEAE LKLVEEKCRE
410 420 430 440 450
FGVSVKLSEV WAKGGEGGIE VAKEVLRLIN EGKNDFQFAY DEKLPIRDKI
460 470 480 490 500
RAIAQKIYGA DGVTFTNQAE KEIDELEKLG FGKTPVCIAK TQYSLTDDQN
510 520 530 540 550
KLGRPKGFKI TVRQVSISAG AGFVVAITGS IMKMPGLPKV PAAEKIDVDE

NGVISGLF
Length:558
Mass (Da):60,414
Last modified:March 24, 2009 - v1
Checksum:i6E7ABE3A88C40AE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009049 Genomic DNA. Translation: BAH05436.1.
RefSeqiWP_011989009.1. NC_011837.1.
YP_002470850.1. NC_011837.1.

Genome annotation databases

EnsemblBacteriaiBAH05436; BAH05436; CKR_0385.
GeneIDi7276342.
KEGGickr:CKR_0385.
PATRICi19470458. VBICloKlu118830_0488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009049 Genomic DNA. Translation: BAH05436.1 .
RefSeqi WP_011989009.1. NC_011837.1.
YP_002470850.1. NC_011837.1.

3D structure databases

ProteinModelPortali B9DYW1.
SMRi B9DYW1. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 583346.CKR_0385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH05436 ; BAH05436 ; CKR_0385 .
GeneIDi 7276342.
KEGGi ckr:CKR_0385.
PATRICi 19470458. VBICloKlu118830_0488.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CKLU583346:GJNQ-418-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Clostridium kluyveri and comparative genomics of Clostridia species."
    Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K., Vertes A.A., Yukawa H.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 12016.

Entry informationi

Entry nameiFTHS_CLOK1
AccessioniPrimary (citable) accession number: B9DYW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3